Search Results - "Tam, Patrick Pl"

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation by Fan, Xiaochen, Masamsetti, V Pragathi, Sun, Jane Qj, Engholm-Keller, Kasper, Osteil, Pierre, Studdert, Joshua, Graham, Mark E, Fossat, Nicolas, Tam, Patrick Pl

“…Protein interaction is critical molecular regulatory activity underlining cellular functions and precise cell fate choices. Using TWIST1…”
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Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta by Zamir, Lyad, Singh, Reena, Nathan, Elisha, Patrick, Ralph, Yifa, Oren, Yahalom-Ronen, Yfat, Arraf, Alaa A, Schultheiss, Thomas M, Suo, Shengbao, Han, Jing-Dong Jackie, Peng, Guangdun, Jing, Naihe, Wang, Yuliang, Palpant, Nathan, Tam, Patrick Pl, Harvey, Richard P, Tzahor, Eldad

“…Novel regenerative therapies may stem from deeper understanding of the mechanisms governing cardiovascular lineage diversification. Using enhancer mapping and…”
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Building the mouse gastrula: signals, asymmetry and lineages by Tam, Patrick PL, Loebel, David AF, Tanaka, Satomi S

“…The mouse embryo is built by assembling the progenitors of various tissue types into a body plan. Early postimplantation development involves the establishment…”
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Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq by Chen, Jun, Suo, Shengbao, Tam, Patrick PL, Han, Jing-Dong J, Peng, Guangdun, Jing, Naihe

“…Geo-seq combines laser capture microdissection and single-cell RNA-seq technology to enable transcriptome analysis of small quantities of cells from defined…”
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Gene function in mouse embryogenesis: get set for gastrulation by Tam, Patrick P. L, Loebel, David A. F

“…During early mouse embryogenesis, temporal and spatial regulation of gene expression and cell signalling influences lineage specification, embryonic polarity,…”
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Wnt signalling in mouse gastrulation and anterior development: new players in the pathway and signal output by Arkell, Ruth M, Fossat, Nicolas, Tam, Patrick PL

“…Embryonic development and adult homeostasis are dependent upon the coordinated action of signal transduction pathways such as the Wnt signalling pathway which…”
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Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome -Mecp2 gene dosage effects and BDNF expression by Kondo, Mari, Gray, Laura J., Pelka, Gregory J., Christodoulou, John, Tam, Patrick P. L., Hannan, Anthony J.

“…Rett syndrome, commonly associated with mutations of the methyl CpG‐binding protein 2 (MECP2) gene, is characterised by an apparently normal early postnatal…”
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Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance by Bildsoe, Heidi, Fan, Xiaochen, Wilkie, Emilie E., Ashoti, Ator, Jones, Vanessa J., Power, Melinda, Qin, Jing, Wang, Junwen, Tam, Patrick P.L., Loebel, David A.F.

“…TWIST1, a basic helix-loop-helix transcription factor is essential for the development of cranial mesoderm and cranial neural crest-derived craniofacial…”
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Head formation: OTX2 regulates Dkk1 and Lhx1 activity in the anterior mesendoderm by Ip, Chi Kin, Fossat, Nicolas, Jones, Vanessa, Lamonerie, Thomas, Tam, Patrick P L

“…The Otx2 gene encodes a paired-type homeobox transcription factor that is essential for the induction and the patterning of the anterior structures in the…”
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Definitive endoderm of the mouse embryo: Formation, cell fates, and morphogenetic function by Lewis, Samara L., Tam, Patrick P.L.

“…The endoderm is one of the primary germ layers but, in comparison to ectoderm and mesoderm, has received less attention. The definitive endoderm forms during…”
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Chromatin context and ncRNA highlight targets of MeCP2 in brain by Maxwell, Scott S, Pelka, Gregory J, Tam, Patrick PL, El-Osta, Assam

“…The discovery that Rett syndrome (RTT) is caused by mutation of the methyl-CpG-binding-protein MeCP2 provided a major breakthrough in understanding the…”
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Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization by Greenlees, Rebecca, Mihelec, Marija, Yousoof, Saira, Speidel, Daniel, Wu, Selwin K, Rinkwitz, Silke, Prokudin, Ivan, Perveen, Rahat, Cheng, Anson, Ma, Alan, Nash, Benjamin, Gillespie, Rachel, Loebel, David A F, Clayton-Smith, Jill, Lloyd, I Christopher, Grigg, John R, Tam, Patrick P L, Yap, Alpha S, Becker, Thomas S, Black, Graeme C M, Semina, Elena, Jamieson, Robyn V

“…Correct morphogenesis and differentiation are critical in development and maintenance of the lens, which is a classic model system for epithelial development…”
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Affective dysfunction in a mouse model of Rett syndrome: Therapeutic effects of environmental stimulation and physical activity by Kondo, Mari A., Gray, Laura J., Pelka, Gregory J., Leang, Sook‐Kwan, Christodoulou, John, Tam, Patrick P. L., Hannan, Anthony J.

“…ABSTRACT Rett syndrome (RTT) is a neurodevelopmental disorder associated with mutations in the X‐linked gene encoding methyl‐CpG‐binding protein 2 (MeCP2) and…”
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Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo by Fossat, Nicolas, Ip, Chi Kin, Jones, Vanessa J, Studdert, Joshua B, Khoo, Poh-Lynn, Lewis, Samara L, Power, Melinda, Tourle, Karin, Loebel, David A F, Kwan, Kin Ming, Behringer, Richard R, Tam, Patrick P L

“…Lhx1 encodes a LIM homeobox transcription factor that is expressed in the primitive streak, mesoderm and anterior mesendoderm of the mouse embryo. Using a…”
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Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice by Pelka, Gregory J., Watson, Catherine M., Radziewic, Tania, Hayward, Melinda, Lahooti, Hooshang, Christodoulou, John, Tam, Patrick P. L.

“…Rett syndrome (RTT) is a debilitating neurological condition associated with mutations in the X-linked MECP2 gene, where apparently normal development is seen…”
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Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype by Williamson, Sarah L, Ellaway, Carolyn J, Peters, Greg B, Pelka, Gregory J, Tam, Patrick P L, Christodoulou, John

“…Rett syndrome (RTT), a neurodevelopmental disorder that predominantly affects females, is primarily caused by variants in MECP2. Variants in other genes such…”
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Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo by Fossat, Nicolas, Jones, Vanessa, Khoo, Poh-Lynn, Bogani, Debora, Hardy, Andrea, Steiner, Kirsten, Mukhopadhyay, Mahua, Westphal, Heiner, Nolan, Patrick M, Arkell, Ruth, Tam, Patrick P L

“…In mouse embryos, loss of Dickkopf-1 (DKK1) activity is associated with an ectopic activation of WNT signalling responses in the precursors of the craniofacial…”
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Differential response of epiblast stem cells to Nodal and Activin signalling: a paradigm of early endoderm development in the embryo by Kaufman-Francis, Keren, Goh, Hwee Ngee, Kojima, Yoji, Studdert, Joshua B., Jones, Vanessa, Power, Melinda D., Wilkie, Emilie, Teber, Erdahl, Loebel, David A. F., Tam, Patrick P. L.

“…Mouse epiblast stem cells (EpiSCs) display temporal differences in the upregulation of Mixl1 expression during the initial steps of in vitro differentiation,…”
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Chapter Twenty-Nine - Formation of the Embryonic Head in the Mouse: Attributes of a Gene Regulatory Network by Tam, Patrick PL, Fossat, Nicolas, Wilkie, Emilie, Loebel, David AF, Ip, Chi Kin, Ramialison, Mirana

“…The embryonic head is the first major body part to be constructed during embryogenesis. The allocation and the assembly of the progenitor tissues, which start…”
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A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain by Williamson, Sarah L., Giudici, Laura, Kilstrup-Nielsen, Charlotte, Gold, Wendy, Pelka, Gregory J., Tam, Patrick P. L., Grimm, Andrew, Prodi, Dionigio, Landsberger, Nicoletta, Christodoulou, John

“…The X-linked cyclin-dependent kinase-like 5 ( CDKL5 ) gene is an important molecular determinant of early-onset intractable seizures with infantile spasms and…”
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