Search Results - "Tam, Kin Yip"

Pathological mechanisms and therapeutic strategies for Alzheimer's disease by Ju, Yaojun, Tam, Kin

“…Alzheimer's disease is a rather complex neurodegenerative disease, which is attributed to a combination of multiple factors. Among the many pathological…”
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The development of small-molecule inhibitors targeting hexokinase 2 by Shan, Wenying, Zhou, Yan, Tam, Kin Yip

“…•HK2 inhibitors targeting cancer metabolism is described and classified according to their binding modes with the target.•Structural details of the binding…”
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Systemic clearance and brain distribution of carbazole-based cyanine compounds as Alzheimer’s disease drug candidates by Zhou, Wei, Hu, Xiaohui, Tam, Kin Yip

“…SLM and SLOH, two analogues of carbazole-based cyanine compounds, have been shown to inhibit β-amyloid peptide aggregation in vitro and in Alzheimer’s disease…”
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Cytosolic malic enzyme and glucose-6-phosphate dehydrogenase modulate redox balance in NSCLC with acquired drug resistance by Ran, Maoxin, Zhou, Yan, Guo, Yizhen, Huang, Ding, Zhang, Shao-Lin, Tam, Kin Yip

“…Lung cancer cells often show elevated levels of reactive oxygen species (ROS) and nicotinamide adenine dinucleotide phosphate (NADPH). However, the connections…”
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Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer’s Disease by Kosaraju, Jayasankar, Holsinger, R. M. Damian, Guo, Lixia, Tam, Kin Yip

“…Glucagon-like peptide-1 (GLP-1) is an incretin hormone shown to be active in the treatment of type-2 diabetes (T2D) and has also been shown as efficacious in…”
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Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target? by Zhang, Wen, Zhang, Shao-Lin, Hu, Xiaohui, Tam, Kin Yip

“…Cancer remains a lethal threat to global lives. Development of novel anticancer therapeutics is still a challenge to scientists in the field of biomedicine. In…”
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Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation by Zhang, Qingyu, Zhou, Wei, Yu, Shan, Ju, Yaojun, To, Sally Kit Yan, Wong, Alice Sze Tsai, Jiao, Yufei, Poon, Terence Chuen Wai, Tam, Kin Yip, Lee, Leo Tsz On

“…As a result of the hostile microenvironment, metabolic alterations are required to enable the malignant growth of cancer cells. To understand metabolic…”
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Recent developments of human monocarboxylate transporter (hMCT) inhibitors as anticancer agents by Wu, Puhua, Zhou, Yan, Guo, Yizhen, Zhang, Shao-Lin, Tam, Kin Yip

“…•Recent development of hMCTs inhibitors targeting cancer metabolism is described.•Structural information of hMCT1 and hMCT4 is summarized for rational…”
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Epigallocatechin gallate circumvents drug‐induced resistance in non‐small‐cell lung cancer by modulating glucose metabolism and AMPK/AKT/MAPK axis by Zhou, Yan, Huang, Shiqi, Guo, Yizhen, Ran, Maoxin, Shan, Wenying, Chen, Wen‐Hua, Tam, Kin Yip

“…Upon prolonged use of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non‐small‐cell lung cancer (NSCLC), acquired drug resistance…”
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UBQLN2 and HSP70 participate in Parkin‐mediated mitophagy by facilitating outer mitochondrial membrane rupture by Ma, Qilian, Xin, Jiaqi, Peng, Qiang, Li, Ningning, Sun, Shan, Hou, Hongyu, Ma, Guoqiang, Wang, Nana, Zhang, Li, Tam, Kin Yip, Dussmann, Heiko, Prehn, Jochen HM, Wang, Hongfeng, Ying, Zheng

“…Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two aging‐related neurodegenerative diseases that share common key features,…”
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Sphingolipidomic Analysis of C. elegans reveals Development- and Environment-dependent Metabolic Features by Cheng, Xiaoxiang, Jiang, Xue, Tam, Kin Yip, Li, Gang, Zheng, Jun, Zhang, Hongjie

“…Sphingolipids (SLs) serve as structural and signaling molecules in regulating various cellular events and growth. Given that SLs contain various bioactive…”
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Causal interactions in resting-state networks predict perceived loneliness by Tian, Yin, Yang, Li, Chen, Sifan, Guo, Daqing, Ding, Zechao, Tam, Kin Yip, Yao, Dezhong

“…Loneliness is broadly described as a negative emotional response resulting from the differences between the actual and desired social relations of an…”
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Combined use of arginase and dichloroacetate exhibits anti‐proliferative effects in triple negative breast cancer cells by Verma, Angela, Lam, Yau‐Min, Leung, Yun‐Chung, Hu, Xiaohui, Chen, Xin, Cheung, Edwin, Tam, Kin Yip

“…Objectives Drug combination in cancer therapy aims to achieve synergistic therapeutic effect, reduced drug dosage, reduced drug toxicity and minimizes or…”
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Trichosanthin Promotes Anti-Tumor Immunity through Mediating Chemokines and Granzyme B Secretion in Hepatocellular Carcinoma by Wang, Kaifang, Wang, Xiaona, Zhang, Minghuan, Ying, Zhenguang, Zhu, Zeyao, Tam, Kin Yip, Li, Chunman, Zhou, Guowei, Gao, Feng, Zeng, Meiqi, Sze, Stephen Cho Wing, Wang, Xia, Sha, Ou

“…Trichosanthin (TCS) is a type I ribosome-inactivating protein extracted from the tuberous root of the plant . TCS shows promising potential in clinical drug…”
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The oral manifestations and related mechanisms of COVID-19 caused by SARS-CoV-2 infection by Lin, Weiming, Gao, Feng, Wang, Xia, Qin, Nianhong, Chen, Xianxiong, Tam, Kin Yip, Zhang, Chengfei, Zhang, Mingxia, Sha, Ou

“…Coronavirus disease 2019 (COVID-19) was reported to be associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, and patients…”
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Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-TKI–Mediated Anticancer Activity in NSCLC by Yang, Zheng, Chan, Kin Iong, Kwok, Hang Fai, Tam, Kin Yip

“…Epidermal growth factor receptor (EGFR) mutations were found in 30%-40% of non–small cell lung cancer (NSCLC) patients, who often responded well to EGFR…”
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Synthesis and biological evaluation of aza-crown ether–squaramide conjugates as anion/cation symporters by Yu, Xi-Hui, Cai, Xiong-Jie, Hong, Xiao-Qiao, Tam, Kin Yip, Zhang, Kun, Chen, Wen-Hua

“…Anion/cation symport across cellular membranes may lead to cell apoptosis and be developed as a strategy for new anticancer drug discovery. Four aza-crown…”
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PRKN regulates inner mitochondrial membrane PHB2 during mitophagy by Sun, Shan, Wang, Hongfeng, Ma, Qilian, Li, Ningning, Cao, Mian, Tam, Kin Yip, Ying, Zheng

“…PINK1 (PTEN induced kinase 1) and PRKN-mediated mitophagy is an important mitochondrial quality control pathway which selectively degrades damaged mitochondria…”
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ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2-BECN1 interaction by Xu, Shiqiang, Ma, Qilian, Shen, Junwen, Li, Ningning, Sun, Shan, Wang, Nana, Chen, Yang, Dong, Chunsheng, Tam, Kin Yip, Prehn, Jochen H M, Wang, Hongfeng, Ying, Zheng

“…Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal…”
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Chlorpromazine affects autophagy in association with altered Rag GTPase–mTORC1–TFEB signaling by Li, Ningning, Rao, Lingling, Zhao, Xueqing, Shen, Junwen, Su, Dan, Ma, Guoqiang, Sun, Shan, Ma, Qilian, Zhang, Li, Dong, Chunsheng, Tam, Kin Yip, Prehn, Jochen H. M., Wang, Hongfeng, Ying, Zheng

“…Autophagy is a critical protein and organelle quality control system, which regulates cellular homeostasis and survival. Growing pieces of evidence suggest…”
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