Search Results - "Tam, Benjamin"

Applications of Molecular Dynamics Simulation in Protein Study by Sinha, Siddharth, Tam, Benjamin, Wang, San Ming

“…Molecular Dynamics (MD) Simulations is increasingly used as a powerful tool to study protein structure-related questions. Starting from the early simulation…”
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NMR-Fragment Based Virtual Screening: A Brief Overview by Singh, Meenakshi, Tam, Benjamin, Akabayov, Barak

“…Fragment-based drug discovery (FBDD) using NMR has become a central approach over the last twenty years for development of small molecule inhibitors against…”
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RBD Double Mutations of SARS-CoV-2 Strains Increase Transmissibility through Enhanced Interaction between RBD and ACE2 Receptor by Sinha, Siddharth, Tam, Benjamin, Wang, San Ming

“…The COVID-19 pandemic, caused by SARS-CoV-2, has led to catastrophic damage for global human health. The initial step of SARS-CoV-2 infection is the binding of…”
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Classification of MLH1 Missense VUS Using Protein Structure-Based Deep Learning-Ramachandran Plot-Molecular Dynamics Simulations Method by Tam, Benjamin, Qin, Zixin, Zhao, Bojin, Sinha, Siddharth, Lei, Chon Lok, Wang, San Ming

“…Pathogenic variation in DNA mismatch repair (MMR) gene is associated with Lynch syndrome (LS), an autosomal dominant hereditary cancer. Of the 3798 germline…”
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Comprehensive Identification of Deleterious TP53 Missense VUS Variants Based on Their Impact on TP53 Structural Stability by Tam, Benjamin, Sinha, Siddharth, Qin, Zixin, Wang, San Ming

“…TP53 plays critical roles in maintaining genome stability. Deleterious genetic variants damage the function of TP53, causing genome instability and increased…”
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Combining Ramachandran plot and molecular dynamics simulation for structural-based variant classification: Using TP53 variants as model by Tam, Benjamin, Sinha, Siddharth, Wang, San Ming

“…[Display omitted] The wide application of new DNA sequencing technologies is generating vast quantities of genetic variation data at unprecedented speed…”
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Prognostic accuracy of the Hamilton Early Warning Score (HEWS) and the National Early Warning Score 2 (NEWS2) among hospitalized patients assessed by a rapid response team by Fernando, Shannon M, Fox-Robichaud, Alison E, Rochwerg, Bram, Cardinal, Pierre, Seely, Andrew J E, Perry, Jeffrey J, McIsaac, Daniel I, Tran, Alexandre, Skitch, Steven, Tam, Benjamin, Hickey, Michael, Reardon, Peter M, Tanuseputro, Peter, Kyeremanteng, Kwadwo

“…Rapid response teams (RRTs) respond to hospitalized patients experiencing clinical deterioration and help determine subsequent management and disposition. We…”
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OpenSHC: A Versatile Multilegged Robot Controller by Tam, Benjamin, Talbot, Fletcher, Steindl, Ryan, Elfes, Alberto, Kottege, Navinda

“…Multilegged robots have the ability to perform stable locomotion on relatively rough terrain. However, the complexity of legged robots over wheeled or tracked…”
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Machine learning approaches to optimize small-molecule inhibitors for RNA targeting by Grimberg, Hadar, Tiwari, Vinay S., Tam, Benjamin, Gur-Arie, Lihi, Gingold, Daniela, Polachek, Lea, Akabayov, Barak

“…In the era of data science, data-driven algorithms have emerged as powerful platforms that can consolidate bioisosteric rules for preferential modifications on…”
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Integration of deep learning with Ramachandran plot molecular dynamics simulation for genetic variant classification by Tam, Benjamin, Qin, Zixin, Zhao, Bojin, Wang, San Ming, Lei, Chon Lok

“…Functional classification of genetic variants is a key for their clinical applications in patient care. However, abundant variant data generated by the…”
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Head and Neck Cancer Online Support Groups: Disparities in Participation and Impact on Patients by Tam, Benjamin, Lin, Matthew, Castellanos, Carlos, Ulloa, Ruben, Kokot, Niels, Hur, Kevin

“…Objective To characterize the users of the head and neck cancer (HNC) online support group (OSG) and describe the perceived benefits of membership. Study…”
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Evolutionary Origin of MUTYH Germline Pathogenic Variations in Modern Humans by Xiao, Fengxia, Li, Jiaheng, Lagniton, Philip Naderev Panuringan, Kou, Si Hoi, Lei, Huijun, Tam, Benjamin, Wang, San Ming

“…MUTYH plays an essential role in preventing oxidation-caused DNA damage. Pathogenic germline variations in damage its function, causing intestinal polyposis…”
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Association of ethnicity and time to surgery among patients with chronic rhinosinusitis by Tam, Benjamin, Collet, Casey, Le, Jessica, Badash, Ido, Garcia, Erick, Wrobel, Bozena, Rice, Dale, Hur, Kevin

“…Objectives Determine factors associated with delayed endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS). Methods This is a…”
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The effect of rapid response teams on end-of-life care: a retrospective chart review by Tam, Benjamin, Salib, Mary, Fox-Robichaud, Alison

“…A subset of critically ill patients have end-of-life (EOL) goals that are unclear. Rapid response teams (RRTs) may aid in the identification of these patients…”
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An Exploratory Analysis of the Chronic Rhinosinusitis Online Support Community by Ulloa, Ruben, Tam, Benjamin, Orozco, Francis Reyes, Castellanos, Carlos X., Chang, Michael T., Hur, Kevin

“…Objective To characterize the users of the largest chronic rhinosinusitis (CRS) online support communities (OSCs), describe the perceived benefits of OSCs for…”
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Scale-up and sustainability of a personalized end-of-life care intervention: a longitudinal mixed-methods study by Takaoka, Alyson, Tam, Benjamin, Vanstone, Meredith, Clarke, France J, Hoad, Neala, Swinton, Marilyn, Toledo, Feli, Boyle, Anne, Woods, Anne, Duan, Erick H, Heels-Ansdell, Diane, Waugh, Lily, Soth, Mark, Rudkowski, Jill, Alhazzani, Waleed, Perri, Dan, Ligori, Tania, Jaeschke, Roman, Zytaruk, Nicole, Cook, Deborah J

“…Scaling-up and sustaining healthcare interventions can be challenging. Our objective was to describe how the 3 Wishes Project (3WP), a personalized end-of-life…”
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DnaG Primase-A Target for the Development of Novel Antibacterial Agents by Ilic, Stefan, Cohen, Shira, Singh, Meenakshi, Tam, Benjamin, Dayan, Adi, Akabayov, Barak

“…The bacterial primase-an essential component in the replisome-is a promising but underexploited target for novel antibiotic drugs. Bacterial primases have a…”
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Current otolaryngologic applications of the novel self‐assembling RADA‐16 peptide matrix by Pak, Kaitlynne Y., Tang, Dennis M., Sreenath, Satyan B., Ito, Christopher J., Senior, Brent A., Lam, Kent K., Higgins, Thomas S., Hur, Kevin, Tam, Benjamin, Khalid, Ayesha N., Wu, Arthur W.

“…A novel bioresorbable agent on the market is PuraGel® (3‐D Matrix, Tokyo, Japan), a RADA‐16 product that acts as a synthetic hemostatic and space‐filling gel…”
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Suppression of core 1 Gal-transferase is associated with reduction of TF and reciprocal increase of Tn, sialyl-Tn and Core 3 glycans in human colon cancer cells by Barrow, Hannah, Tam, Benjamin, Duckworth, Carrie A, Rhodes, Jonathan M, Yu, Lu-Gang

“…It has long been presumed, though with surprisingly little evidence, a competition between Core 1 Gal-transferase (C1GalT), Core 3 GlcNAc-transferase (C3GnT)…”
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Exploring a targeted approach for public health capacity restrictions during COVID-19 using a new computational model by Micuda, Ashley N., Anderson, Mark R., Babayan, Irina, Bolger, Erin, Cantin, Logan, Groth, Gillian, Pressman-Cyna, Ry, Reed, Charlotte Z., Rowe, Noah J., Shafiee, Mehdi, Tam, Benjamin, Vidal, Marie C., Ye, Tianai, Martin, Ryan D.

“…This work introduces the Queen's University Agent-Based Outbreak Outcome Model (QUABOOM). This tool is an agent-based Monte Carlo simulation for modelling…”
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