Search Results - "Tam, Amy Sze Pui"

A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv) by Tu, Chao, Terraube, Virginie, Tam, Amy Sze Pui, Stochaj, Wayne, Fennell, Brian J., Lin, Laura, Stahl, Mark, LaVallie, Edward R., Somers, Will, Finlay, William J.J., Mosyak, Lydia, Bard, Joel, Cunningham, Orla

“…Antibody v-domains in scFv format often suffer from aggregation and stability issues that restrict formulation. Structural and empirical analyses of an…”
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CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery by Fennell, Brian J, McDonnell, Barry, Tam, Amy Sze Pui, Chang, Lijun, Steven, John, Broadbent, Ian D, Gao, Huilan, Kieras, Elizabeth, Alley, Jennifer, Luxenberg, Deborah, Edmonds, Jason, Fitz, Lori J, Miao, Wenyan, Whitters, Matthew J, Medley, Quintus G, Guo, Yongjing J, Darmanin-Sheehan, Alfredo, Autin, Bénédicte, Shúilleabháin, Deirdre Ní, Cummins, Emma, King, Amy, Krebs, Mark RH, Grace, Christopher, Hickling, Timothy P, Boisvert, Angela, Zhong, Xiaotian, McKenna, Matthew, Francis, Christopher, Olland, Stephane, Bloom, Laird, Paulsen, Janet, Somers, Will, Jensen, Allan, Lin, Laura, Finlay, William JJ, Cunningham, Orla

“…While myriad molecular formats for bispecific antibodies have been examined to date, the simplest structures are often based on the scFv. Issues with stability…”
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Purification and Characterization of Active Plk‐1 Produced in E. coli and Baculovirus‐Infected Sf9 Insect Cells by Tam, Amy Sze Pui, Malakian, Karl, Benard, Susan, Kelleher, Kerry, Liu, Yan, Tan, Xingzhi, Loganzo, Frank, Siegel, Marshall, Kriz, Ron, Somers, Will, Stahl, Mark, Lin, Laura

“…The mammalian protein kinase Polo‐Like Kinase‐1 (Plk‐1) is an important regulator of mitosis. It is involved in the signaling networks that regulate many cell…”
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Purification and Characterization of Recombinant Activin Receptor Type IIB Kinase Expressed In Sf9 Cells by Tam, Amy Sze Pui, Bean, Kevin, Kelleher, Kerry, Marvell, Todd, Ross, Cindy, Kim, Richard, Celeste, Tony, Siegel, Marshall, Kriz, Ron, Somers, Will, Stahl, Mark, Lin, Laura

“…Activin Receptor Type IIB (ActRIIB) is a member of the transforming growth factor‐β1 (TGF‐β1) superfamily that has been shown to bind to myostatin/GDF‐8. Upon…”
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