Search Results - "Talyzina, A"
-
1
Structure of the human Mediator-bound transcription preinitiation complex
Published in Science (American Association for the Advancement of Science) (02-04-2021)“…Eukaryotic transcription requires the assembly of a multisubunit preinitiation complex (PIC) composed of RNA polymerase II (Pol II) and the general…”
Get full text
Journal Article -
2
Structure of human TRPV4 in complex with GTPase RhoA
Published in Nature communications (23-06-2023)“…Transient receptor potential (TRP) channel TRPV4 is a polymodal cellular sensor that responds to moderate heat, cell swelling, shear stress, and small-molecule…”
Get full text
Journal Article -
3
TIR domains of TLR family-from the cell culture to the protein sample for structural studies
Published in PloS one (05-07-2024)“…Toll-like receptors (TLRs) are key players in the innate immune system. Despite the great efforts in TLR structural biology, today we know the spatial…”
Get full text
Journal Article -
4
Comparison of histone-like HU protein DNA-binding properties and HU/IHF protein sequence alignment
Published in PloS one (13-11-2017)“…The structure and function of bacterial nucleoid are controlled by histone-like proteins of HU/IHF family, omnipresent in bacteria and also founding archaea…”
Get full text
Journal Article -
5
Structural insights into thrombolytic activity of destabilase from medicinal leech
Published in Scientific reports (24-04-2023)“…Destabilase from the medical leech Hirudo medicinalis belongs to the family of i-type lysozymes. It has two different enzymatic activities: microbial cell…”
Get full text
Journal Article -
6
Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions
Published in Communications biology (24-08-2021)“…Toll-like receptors (TLRs) play an important role in the innate immune response. While a lot is known about the structures of their extracellular parts, many…”
Get full text
Journal Article -
7
Virtual Screening Targeting Dimerization Signals of Two Mycoplasma HU Proteins Revealed Different Types of Inhibitors Interacting with Common Binding Determinants
Published in Crystallography reports (01-07-2019)“…DNA-Binding HU proteins are critical to the maintenance of the nucleoid structure and are promising pharmacological targets for the design of new antibiotics…”
Get full text
Journal Article -
8
Molecular Dynamics Study of Binding of Substrates Bearing Two Positively Charged Residues to Oligopeptidase B from Serratia proteamaculans
Published in Crystallography reports (01-09-2019)“…The behavior of the peptide substrates GlyArgArgGly and GlyLysArgGly, which contain arginine or lysine at the Р2 position, in the active site of oligopeptidase…”
Get full text
Journal Article -
9
Application of virtual screening and molecular dynamics for the analysis of selectivity of inhibitors of HU proteins targeted to the DNA-recognition site
Published in Crystallography reports (01-11-2017)“…DNA-Binding HU proteins are essential for the maintenance of genomic DNA supercoiling and compaction in prokaryotic cells and are promising pharmacological…”
Get full text
Journal Article -
10
TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site
Published in Science advances (03-05-2024)“…TRPV3 represents both temperature- and ligand-activated transient receptor potential (TRP) channel. Physiologically relevant opening of TRPV3 channels by heat…”
Get full text
Journal Article -
11
Medicinal leech antimicrobial peptides lacking toxicity represent a promising alternative strategy to combat antibiotic-resistant pathogens
Published in European journal of medicinal chemistry (15-10-2019)“…The rise of antibiotic resistance has necessitated the development of alternative strategies for the treatment of infectious diseases. Antimicrobial peptides…”
Get full text
Journal Article -
12
Structural plasticity and thermal stability of the histone-like protein from Spiroplasma melliferum are due to phenylalanine insertions into the conservative scaffold
Published in Journal of biomolecular structure & dynamics (10-12-2018)“…The histone-like (HU) protein is one of the major nucleoid-associated proteins of the bacterial nucleoid, which shares high sequence and structural similarity…”
Get full text
Journal Article -
13
Enhanced conformational flexibility of the histone-like (HU) protein from Mycoplasma gallisepticum
Published in Journal of biomolecular structure & dynamics (02-01-2018)“…The histone-like (HU) protein is one of the major nucleoid-associated proteins involved in DNA supercoiling and compaction into bacterial nucleoid as well as…”
Get full text
Journal Article -
14
Structure of the human Mediator-bound transcription pre-initiation complex
Published in Science (American Association for the Advancement of Science) (11-03-2021)“…Eukaryotic transcription requires the assembly of a multi-subunit pre-initiation complex (PIC) comprised of RNA polymerase II (Pol II) and the general…”
Get full text
Journal Article -
15
The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability
Published in The Journal of immunology (1950) (15-04-2018)“…Human cancers frequently display defects in Ag processing and presentation allowing for immune evasion, and they therefore constitute a significant challenge…”
Get full text
Journal Article -
16
Prediction of dose response for radiation induced exchange aberrations taking cell cycle delays into account
Published in Radiation protection dosimetry (01-12-2006)“…Chromosomal aberrations (CAs) are regarded as one of the most sensitive biological indicators of genetic alterations. The aberration frequency is routinely…”
Get full text
Journal Article -
17
Vaccination with proline-substituted neoepitope Trh4 generates enhanced CTL responses against tumors
Published in SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2017)Get full text
Conference Proceeding -
18
Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn 2+ ions
Published in Communications biology (24-08-2021)“…Toll-like receptors (TLRs) play an important role in the innate immune response. While a lot is known about the structures of their extracellular parts, many…”
Get full text
Journal Article -
19
ANTINEOPLASTIC ACTION OF ANTIBIOTIC CHRYSOMALLIN
Published in Federation proceedings. Translation supplement; selected translations from medical-related science (01-11-1964)Get more information
Journal Article -
20
EFFECT OF OLIVOMYCIN ON TRANSPLANTABLE TUMORS
Published in Federation proceedings. Translation supplement; selected translations from medical-related science (01-11-1963)Get more information
Journal Article