Search Results - "Talts, Jan F."

Laminin isoforms in development and disease by SCHEELE, Susanne, NYSTRÖM, Alexander, DURBEEJ, Madeleine, TALTS, Jan F, EKBLOM, Marja, EKBLOM, Peter

“…The members of the laminin family of heterotrimers are major constituents of all basement membranes, sheet-like extracellular structures, present in almost all…”
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Expression and biological role of laminin-1 by Ekblom, Peter, Lonai, Peter, Talts, Jan F.

“…Of the approximately 15 laminin trimers described in mammals, laminin-1 expression seems to be largely limited to epithelial basement membranes. It appears…”
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The major basement membrane components localize to the chondrocyte pericellular matrix — A cartilage basement membrane equivalent? by Kvist, Alexander J., Nyström, Alexander, Hultenby, Kjell, Sasaki, Takako, Talts, Jan F., Aspberg, Anders

“…In this study, we demonstrate that articular cartilage chondrocytes are surrounded by the defining basement membrane proteins laminin, collagen type IV,…”
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Role of the Cell Wall Phenolic Glycolipid-1 in the Peripheral Nerve Predilection of Mycobacterium leprae by Ng, Vincent, Zanazzi, George, Timpl, Rupert, Talts, Jan F, Salzer, James L, Brennan, Patrick J, Rambukkana, Anura

“…The cell wall of pathogenic mycobacteria is abundant with complex glycolipids whose roles in disease pathogenesis are mostly unknown. Here, we provide evidence…”
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Integrin α10β1-Selected Mesenchymal Stem Cells Mitigate the Progression of Osteoarthritis in an Equine Talar Impact Model by Delco, Michelle L., Goodale, Margaret, Talts, Jan F., Pownder, Sarah L., Koff, Matthew F., Miller, Andrew D., Nixon, Bridgette, Bonassar, Lawrence J., Lundgren-Åkerlund, Evy, Fortier, Lisa A.

“…Background: Early intervention with mesenchymal stem cells (MSCs) after articular trauma has the potential to limit progression of focal lesions and prevent…”
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Akt/PKB Regulates Laminin and Collagen IV Isotypes of the Basement Membrane by Li, Xiaofeng, Talts, Ulrika, Talts, Jan F., Arman, Esther, Ekblom, Peter, Lonai, Peter

“…Basement membranes are important for epithelial differentiation, cell survival, and normal and metastatic cell migration. Much is known about their breakdown…”
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Binding of the G domains of laminin α1 and α2 chains and perlecan to heparin, sulfatides, α-dystroglycan and several extracellular matrix proteins by Talts, Jan F., Andac, Zeynep, Göhring, Walter, Brancaccio, Andrea, Timpl, Rupert

“…The C‐terminal G domain of the mouse laminin α2 chain consists of five lamin‐type G domain (LG) modules (α2LG1 to α2LG5) and was obtained as several…”
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Structural analysis and proteolytic processing of recombinant G domain of mouse laminin α2 chain by Talts, Jan F, Mann, Karlheinz, Yamada, Yoshihiko, Timpl, Rupert

“…Four individual LG modules from the C-terminus of the laminin α2 chain (LG1, LG2, LG4 and LG5) and combinations of these modules were prepared as recombinant…”
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Beta1 integrin and alpha-dystroglycan binding sites are localized to different laminin-G-domain-like (LG) modules within the laminin alpha5 chain G domain by Yu, Hao, Talts, Jan F

“…Laminins are a group of extracellular-matrix proteins important in development and disease. They are heterotrimers, and specific domains in the different…”
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Structure of the C-terminal laminin G-like domain pair of the laminin α2 chain harbouring binding sites for α-dystroglycan and heparin by Tisi, Dominic, Talts, Jan F., Timpl, Rupert, Hohenester, Erhard

“…The laminins are large heterotrimeric glycoproteins with fundamental roles in basement membrane architecture and function. The C‐terminus of the laminin α…”
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Expression and Distribution of Laminin α1 and α2 Chains in Embryonic and Adult Mouse Tissues: An Immunochemical Approach by Sasaki, Takako, Giltay, Richard, Talts, Ulrika, Timpl, Rupert, Talts, Jan F.

“…Protein levels, mRNA expression, and localization of laminin α1 and α2 chains in development and in adult mice were examined. Recombinant fragments were used…”
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Structural and Functional Analysis of the Recombinant G Domain of the Laminin α4 Chain and Its Proteolytic Processing in Tissues by Talts, Jan F., Sasaki, Takako, Miosge, Nicolai, Göhring, Walter, Mann, Karlheinz, Mayne, Richard, Timpl, Rupert

“…The C-terminal G domains of laminin α chains have been implicated in various cellular and other interactions. The G domain of the α4 chain was now produced in…”
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Mutation of a basic sequence in the laminin α2LG3 module leads to a lack of proteolytic processing and has different effects on β1 integrin-mediated cell adhesion and α-dystroglycan binding by Talts, Jan F, Timpl, Rupert

“…A RRKRRQ sequence unique to the LG3 module of the laminin α2 chain was previously shown to be sensitive to endogenous proteolysis during the recombinant…”
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Opposing Roles of Integrin α6Aβ1 and Dystroglycan in Laminin-mediated Extracellular Signal-regulated Kinase Activation by Ferletta, Maria, Kikkawa, Yamato, Yu, Hao, Talts, Jan F., Durbeej, Madeleine, Sonnenberg, Arnoud, Timpl, Rupert, Campbell, Kevin P., Ekblom, Peter, Genersch, Elke

“…Laminin–integrin interactions can in some settings activate the extracellular signal-regulated kinases (ERKs) but the control mechanisms are poorly understood…”
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Dystroglycan binding to laminin α1LG4 module influences epithelial morphogenesis of salivary gland and lung in vitro by Durbeej, Madeleine, Talts, Jan F., Henry, Michael D., Yurchenco, Peter D., Campbell, Kevin P., Ekblom, Peter

“…Dystroglycan is a receptor for the basement membrane components laminin-1, −2, perlecan, and agrin. Genetic studies have revealed a role for dystroglycan in…”
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Binding of Mouse Nidogen-2 to Basement Membrane Components and Cells and Its Expression in Embryonic and Adult Tissues Suggest Complementary Functions of the Two Nidogens by Salmivirta, Katriina, Talts, Jan F., Olsson, Magnus, Sasaki, Takako, Timpl, Rupert, Ekblom, Peter

“…Nidogen-1 binds several basement membrane components by well-defined, domain-specific interactions. Organ culture and gene targeting approaches suggest that a…”
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Differential expression of muscarinic subtype mRNAs after exposure to neurotoxic pesticides by Talts, Ulrika, Talts, Jan F, Eriksson, Per

“…We have recently reported an increase in the density of muscarinic cholinergic receptors in mice neonatally exposed to a persistent environmental agent,…”
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A simplified laminin nomenclature by Aumailley, Monique, Bruckner-Tuderman, Leena, Carter, William G., Deutzmann, Rainer, Edgar, David, Ekblom, Peter, Engel, Jürgen, Engvall, Eva, Hohenester, Erhard, Jones, Jonathan C.R., Kleinman, Hynda K., Marinkovich, M. Peter, Martin, George R., Mayer, Ulrike, Meneguzzi, Guerrino, Miner, Jeffrey H., Miyazaki, Kaoru, Patarroyo, Manuel, Paulsson, Mats, Quaranta, Vito, Sanes, Joshua R., Sasaki, Takako, Sekiguchi, Kiyotoshi, Sorokin, Lydia M., Talts, Jan F., Tryggvason, Karl, Uitto, Jouni, Virtanen, Ismo, von der Mark, Klaus, Wewer, Ulla M., Yamada, Yoshihiko, Yurchenco, Peter D.

“…A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of α, β and γ chains. Previously, laminin trimers…”
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The Crystal Structure of a Laminin G–like Module Reveals the Molecular Basis of α-Dystroglycan Binding to Laminins, Perlecan, and Agrin by Hohenester, Erhard, Tisi, Dominic, Talts, Jan F., Timpl, Rupert

“…Laminin G–like (LG) modules in the extracellular matrix glycoproteins laminin, perlecan, and agrin mediate the binding to heparin and the cell surface receptor…”
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Structure and function of laminin LG modules by Timpl, Rupert, Tisi, Dominic, Talts, Jan F., Andac, Zeynep, Sasaki, Takako, Hohenester, Erhard

“…Laminin G domain-like (LG) modules of approximately 180–200 residues are found in a number of extracellular and receptor proteins and often are present in…”
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