A prospective randomised single-blinded clinical trial comparing the efficacy and tolerability of the nasal douching products Sterimar™ and Sinus Rinse™ following functional endoscopic sinus surgery

Objectives To compare the efficacy and tolerability of two commonly used nasal douching products, low‐volume high‐pressure Sterimar™ and high‐volume low‐pressure Sinus Rinse™ following functional endoscopic sinus surgery. Design Prospective randomised single‐blinded study. Setting Tertiary referral...

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Bibliographic Details
Published in:	Clinical otolaryngology Vol. 38; no. 4; pp. 297 - 305
Main Authors:	Salib, R.J., Talpallikar, S., Uppal, S., Nair, S.B.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-08-2013 Wiley Subscription Services, Inc
Subjects:	Administration, Intranasal - instrumentation Adult Aged Female Humans Isotonic Solutions - administration & dosage Male Middle Aged Nasal Obstruction - etiology Nasal Obstruction - prevention & control Nasal Polyps - complications Nasal Polyps - surgery Natural Orifice Endoscopic Surgery - adverse effects Patient Preference Postoperative period Prospective Studies Rhinitis - complications Rhinitis - surgery Single-Blind Method Sinuses Sinusitis - complications Sinusitis - surgery Sodium Chloride - administration & dosage Surgery Teenagers Therapeutic Irrigation - instrumentation Tissue Adhesions - etiology Tissue Adhesions - prevention & control Treatment Outcome Young Adult
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Summary:	Objectives To compare the efficacy and tolerability of two commonly used nasal douching products, low‐volume high‐pressure Sterimar™ and high‐volume low‐pressure Sinus Rinse™ following functional endoscopic sinus surgery. Design Prospective randomised single‐blinded study. Setting Tertiary referral centre. Participants Thirty‐one patients, undergoing functional endoscopic sinus surgery for chronic rhinosinusitis with and without polyps, were recruited for the study. The patients acted as their own comparators self‐administering each douche three times daily into one randomly allocated nostril for a period of 12 weeks following the surgery. Main outcome measures The primary outcome measure was a blinded objective endoscopic assessment of each operated side using a modified Lund‐Kennedy endoscopic assessment tool undertaken at 2, 4 and 12 weeks postoperatively. As secondary outcome measures, the patients were asked to express a preference between the two products based on perceived effectiveness and ease of use. Results Compared with the preoperative scores, there was a statistically significant improvement in the SNOT‐22 score at all three postoperative time points (P < 0.001). Compared with week 2, there was a statistically significant reduction in the modified Lund‐Kennedy endoscopic scores (P < 0.05) for both Sterimar™ and Sinus Rinse™ at weeks 4 and 12. When comparing Sterimar™ with SinuRinse™, there was a statistically significant lower modified Lund‐Kennedy score at 2 and 4 weeks postoperatively for the side treated with Sinus Rinse™ (P ≤ 0.05), indicating a more favourable outcome. However, this difference was not apparent at 12 weeks postoperatively (P = 0.66). At all time points, patients perceived Sinus Rinse™ to be more effective than Sterimar™ (P < 0.0001), but there was no significant difference in the patients' preference for either product (P > 0.05). Conclusion High‐volume low‐pressure saline irrigation is recommended as an efficacious, easy to use and well‐tolerated adjunct to endoscopic sinonasal toilet in the early postoperative period following functional endoscopic sinus surgery.
Bibliography:	ArticleID:COA12132 ark:/67375/WNG-3RP89W2L-3 istex:744D3DC933AA1C6E7A11FB4E396AF698C36B0D83 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	1749-4478 1749-4486
DOI:	10.1111/coa.12132