Search Results - "Tallman, A"

Free Radical Oxidation of Polyunsaturated Lipids: New Mechanistic Insights and the Development of Peroxyl Radical Clocks by Pratt, Derek A, Tallman, Keri A, Porter, Ned A

“…The peroxidation of lipids in biological membranes has been implicated in both the onset and development of most degenerative diseases. The primary products of…”
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Stable Histone Adduction by 4‑Oxo-2-nonenal: A Potential Link between Oxidative Stress and Epigenetics by Galligan, James J, Rose, Kristie L, Beavers, William N, Hill, Salisha, Tallman, Keri A, Tansey, William P, Marnett, Lawrence J

“…Lipid electrophiles modify cellular targets, altering their function. Here, we describe histones as major targets for modification by 4-oxo-2-nonenal,…”
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Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling[S] by Wepy, James A., Galligan, James J., Kingsley, Philip J., Xu, Shu, Goodman, Michael C., Tallman, Keri A., Rouzer, Carol A., Marnett, Lawrence J.

“…Lysophospholipids (LysoPLs) are bioactive lipid species involved in cellular signaling processes and the regulation of cell membrane structure. LysoPLs are…”
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Nutritional Adequacy of Animal-Based and Plant-Based Asian Diets for Chronic Kidney Disease Patients: A Modeling Study by Khor, Ban-Hock, Tallman, Dina A, Karupaiah, Tilakavati, Khosla, Pramod, Chan, Maria, Kopple, Joel D

“…Plant-based low protein diets (LPDs) have gained popularity for managing chronic kidney disease (CKD) patients. The nutritional adequacy of these and other…”
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Conversion of 7-Dehydrocholesterol to 7-Ketocholesterol Is Catalyzed by Human Cytochrome P450 7A1 and Occurs by Direct Oxidation without an Epoxide Intermediate by Shinkyo, Raku, Xu, Libin, Tallman, Keri A., Cheng, Qian, Porter, Ned A., Guengerich, F. Peter

“…7-Ketocholesterol is a bioactive sterol, a potent competitive inhibitor of cytochrome P450 7A1, and toxic in liver cells. Multiple origins of this compound…”
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Tofacitinib in patients with moderate‐to‐severe chronic plaque psoriasis: long‐term safety and efficacy in an open‐label extension study by Valenzuela, F., Korman, N.J., Bissonnette, R., Bakos, N., Tsai, T.‐F., Harper, M.K., Ports, W.C., Tan, H., Tallman, A., Valdez, H., Gardner, A.C.

“…Summary Background Tofacitinib is an oral Janus kinase inhibitor. Final safety and efficacy data from an open‐label extension study of tofacitinib in psoriasis…”
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The Effect of Small Molecules on Sterol Homeostasis: Measuring 7‑Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts by Korade, Zeljka, Kim, Hye-Young H, Tallman, Keri A, Liu, Wei, Koczok, Katalin, Balogh, Istvan, Xu, Libin, Mirnics, Karoly, Porter, Ned A

“…Well-established cell culture models were combined with new analytical methods to assess the effects of small molecules on the cholesterol biosynthesis…”
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Dichlorophenyl piperazines, including a recently-approved atypical antipsychotic, are potent inhibitors of DHCR7, the last enzyme in cholesterol biosynthesis by Genaro-Mattos, Thiago C., Tallman, Keri A., Allen, Luke B., Anderson, Allison, Mirnics, Karoly, Korade, Zeljka, Porter, Ned A.

“…While antipsychotic medications provide important relief from debilitating psychotic symptoms, they also have significant adverse side effects, which might…”
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Egg Intake in Chronic Kidney Disease by Tallman, Dina A, Sahathevan, Sharmela, Karupaiah, Tilakavati, Khosla, Pramod

“…Patients with chronic kidney disease (CKD) are often instructed to adhere to a renal-specific diet depending on the severity and stage of their kidney disease…”
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Generation and validation of a conditional knockout mouse model for the study of the Smith-Lemli-Opitz syndrome by Kanuri, Babunageswararao, Fong, Vincent, Ponny, Sithara Raju, Tallman, Keri A., Rao, Sriganesh Ramachandra, Porter, Ned, Fliesler, Steven J., Patel, Shailendra B.

“…Smith-Lemli-Opitz Syndrome (SLOS) is a developmental disorder (OMIM #270400) caused by autosomal recessive mutations in the Dhcr7 gene, which encodes the…”
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Vulnerability of DHCR7+/− mutation carriers to aripiprazole and trazodone exposure by Korade, Zeljka, Genaro-Mattos, Thiago C., Tallman, Keri A., Liu, Wei, Garbett, Krassimira A., Koczok, Katalin, Balogh, Istvan, Mirnics, Karoly, Porter, Ned A.

“…Smith-Lemli-Opitz syndrome is a recessive disorder caused by mutations in 7-dehydrocholesterol reductase (DHCR)7 with a heterozygous (HET) carrier frequency of…”
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Identification of Protein Targets of 4-Hydroxynonenal Using Click Chemistry for ex Vivo Biotinylation of Azido and Alkynyl Derivatives by Vila, Andrew, Tallman, Keri A, Jacobs, Aaron T, Liebler, Daniel C, Porter, Ned A, Marnett, Lawrence J

“…Polyunsaturated fatty acids (PUFA) are primary targets of free radical damage during oxidative stress. Diffusible electrophilic α,β-unsaturated aldehydes, such…”
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Trazodone effects on developing brain by Korade, Zeljka, Allen, Luke B., Anderson, Allison, Tallman, Keri A., Genaro-Mattos, Thiago C., Porter, Ned A., Mirnics, Karoly

“…Trazodone (TRZ) is a commonly prescribed antidepressant with significant off-label use for insomnia. A recent drug screening revealed that TRZ interferes with…”
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Quantitative Evaluations of Time‐Course and Treatment Effects of Systemic Agents for Psoriasis: A Model‐Based Meta‐Analysis by Checchio, T, Ahadieh, S, Gupta, P, Mandema, J, Puig, L, Wolk, R, Valdez, H, Tan, H, Krishnaswami, S, Tallman, A, Kaur, M, Ito, K

“…Aggregate data model‐based meta‐analysis is a regression approach to compare the dose–response and/or time‐course across different treatments using summary…”
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Chronic Aripiprazole and Trazodone Polypharmacy Effects on Systemic and Brain Cholesterol Biosynthesis by Korade, Zeljka, Anderson, Allison, Balog, Marta, Tallman, Keri A, Porter, Ned A, Mirnics, Karoly

“…The concurrent use of several medications is a common practice in the treatment of complex psychiatric conditions. One such commonly used combination is…”
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GAPDH inhibition mediated by thiol oxidation in human airway epithelial cells exposed to an environmental peroxide by Masood, Syed, Kim, Hye-Young H., Pennington, Edward R., Tallman, Keri A., Porter, Ned A., Bromberg, Philip A., Rice, Rebecca L., Gold, Avram, Zhang, Zhenfa, Samet, James M.

“…Intracellular redox homeostasis in the airway epithelium is closely regulated through adaptive signaling and metabolic pathways. However, inhalational exposure…”
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Propagation rate constants for the peroxidation of sterols on the biosynthetic pathway to cholesterol by Lamberson, Connor R., Muchalski, Hubert, McDuffee, Kari B., Tallman, Keri A., Xu, Libin, Porter, Ned A.

“…The free radical chain autoxidation of cholesterol and the oxidation products formed, i.e. oxysterols, have been the focus of intensive study for decades. The…”
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Dietary Patterns and Health Outcomes among African American Maintenance Hemodialysis Patients by Tallman, Dina A, Latifi, Eno, Kaur, Deepinder, Sulaheen, Ayesha, Ikizler, T Alp, Chinna, Karuthan, Mat Daud, Zulfitri Azuan, Karupaiah, Tilakavati, Khosla, Pramod

“…The association between dietary patterns and health outcomes, such as quality of life (QOL), in maintenance hemodialysis (MHD) patients with certain racial…”
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Erratum: Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling by Wepy, James A., Galligan, James J., Kingsley, Phillip J., Xu, Shu, Goodman, Michael C., Tallman, Keri A., Rouzer, Carol A., Marnett, Lawrence J.

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Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target by Beavers, William N, Rose, Kristie L, Galligan, James J, Mitchener, Michelle M, Rouzer, Carol A, Tallman, Keri A, Lamberson, Connor R, Wang, Xiaojing, Hill, Salisha, Ivanova, Pavlina T, Brown, H. Alex, Zhang, Bing, Porter, Ned A, Marnett, Lawrence J

“…Determining the impact of lipid electrophile-mediated protein damage that occurs during oxidative stress requires a comprehensive analysis of electrophile…”
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