Search Results - "Talleur, Aimee"

Allogeneic CAR Cell Therapy-More Than a Pipe Dream by Caldwell, Kenneth J, Gottschalk, Stephen, Talleur, Aimee C

“…Adoptive cellular immunotherapy using immune cells expressing chimeric antigen receptors (CARs) has shown promise, particularly for the treatment of…”
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Hemophagocytic lymphohistiocytosis‐like toxicity (carHLH) after CD19‐specific CAR T‐cell therapy by Hines, Melissa R., Keenan, Camille, Maron Alfaro, Gabriela, Cheng, Cheng, Zhou, Yinmei, Sharma, Akshay, Hurley, Caitlin, Nichols, Kim E., Gottschalk, Stephen, Triplett, Brandon M., Talleur, Aimee C.

“…Summary Chimeric antigen receptor T‐cell (CAR T‐cell) therapy is associated with significant toxicities secondary to immune activation, including a rare but…”
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Chimeric Antigen Receptor T-cell Therapy: Current Status and Clinical Outcomes in Pediatric Hematologic Malignancies by Talleur, Aimee C, Myers, Regina, Annesley, Colleen, Shalabi, Haneen

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CD19-CAR T cells undergo exhaustion DNA methylation programming in patients with acute lymphoblastic leukemia by Zebley, Caitlin C, Brown, Charmaine, Mi, Tian, Fan, Yiping, Alli, Shanta, Boi, Shannon, Galletti, Giovanni, Lugli, Enrico, Langfitt, Deanna, Metais, Jean-Yves, Lockey, Timothy, Meagher, Michael, Triplett, Brandon, Talleur, Aimee C, Gottschalk, Stephen, Youngblood, Ben

“…CD19-CAR T cell therapy has evolved into the standard of care for relapsed/refractory B cell acute lymphoblastic leukemia (ALL); however, limited persistence…”
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A tour de force provides novel insights into CD19-CAR T cell resistance mechanisms by Talleur, Aimee C., Gottschalk, Stephen

“…Sworder et al.1 developed an integrated simultaneous tumor and effector profiling (STEP) approach to study resistance mechanisms to CD19-CAR T cell therapy in…”
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What is the role for HSCT or immunotherapy in pediatric hypodiploid B-cell acute lymphoblastic leukemia? by Talleur, Aimee C, Maude, Shannon L

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Improved survival rate in T-cell depleted haploidentical hematopoietic cell transplantation over the last 15 years at a single institution by Mamcarz, Ewelina, Madden, Renee, Qudeimat, Amr, Srinivasan, Ashok, Talleur, Aimee, Sharma, Akshay, Suliman, Ali, Maron, Gabriela, Sunkara, Anusha, Kang, Guolian, Leung, Wing, Gottschalk, Stephen, Triplett, Brandon M.

“…T-cell depletion of an HLA-haploidentical (haplo) graft is often used to reduce the risk of graft-versus-host disease (GVHD), but the lack of donor T cells in…”
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Outcomes of pediatric patients who relapse after first HCT for acute leukemia or MDS by Sharma, Akshay, Li, Ying, Huang, Sujuan, Talleur, Aimee C., Suliman, Ali, Qudeimat, Amr, Srinivasan, Ashok, Mamcarz, Ewelina, Madden, Renee, Cheng, Cheng, Gottschalk, Stephen, Triplett, Brandon M.

“…Disease relapse remains a major cause of treatment failure in patients receiving allogeneic hematopoietic cell transplantation (alloHCT) for high-risk acute…”
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Acute kidney injury following treatment with CD19-specific CAR T-cell therapy in children, adolescent, and young adult patients with B-cell acute lymphoblastic leukemia by Petgrave, Yonique, Selukar, Subodh, Epperly, Rebecca, Naik, Swati, Santos, Noel DeLos, Triplett, Brandon M., Gottschalk, Stephen, Bissler, John, Talleur, Aimee C.

“…Background CD19-specific chimeric antigen receptor (CAR) T-cell therapy has shown promising disease responses in patients with high-risk B-cell malignancies…”
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Integration of Palliative Care in Hematopoietic Cell Transplant: Pediatric Patient and Parent Needs and Attitudes by Levine, Deena R., Epperly, Rebecca, Collins, Griffin, Talleur, Aimee C., Mandrell, Belinda, Pritchard, Michele, Sarvode Mothi, Suraj, Li, Chen, Lu, Zhaohua, Baker, Justin N.

“…Early integration of palliative care (PC) in hematopoietic cell transplantation (HCT) has demonstrated benefits, yet barriers remain, including perceived lack…”
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Venetoclax-based therapy as a bridge to allogeneic hematopoietic cell transplantation in children with relapsed/refractory AML by Pfeiffer, Thomas, Li, Ying, Ashcraft, Emily, Karol, Seth E., Rubnitz, Jeffrey E., Epperly, Rebecca, Madden, Renee, Mamcarz, Ewelina, Obeng, Esther, Qudeimat, Amr, Sharma, Akshay, Srinivasan, Ashok, Suliman, Ali, Talleur, Aimee C., Velasquez, M. Paulina, Gottschalk, Stephen, Triplett, Brandon M., Naik, Swati

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Common Trajectories of Highly Effective CD19-Specific CAR T Cells Identified by Endogenous T-cell Receptor Lineages by Wilson, Taylor L, Kim, Hyunjin, Chou, Ching-Heng, Langfitt, Deanna, Mettelman, Robert C, Minervina, Anastasia A, Allen, E Kaitlynn, Métais, Jean-Yves, Pogorelyy, Mikhail V, Riberdy, Janice M, Velasquez, M Paulina, Kottapalli, Pratibha, Trivedi, Sanchit, Olsen, Scott R, Lockey, Timothy, Willis, Catherine, Meagher, Michael M, Triplett, Brandon M, Talleur, Aimee C, Gottschalk, Stephen, Crawford, Jeremy Chase, Thomas, Paul G

“…Current chimeric antigen receptor-modified (CAR) T-cell products are evaluated in bulk, without assessing functional heterogeneity. We therefore generated a…”
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Latent human herpesvirus 6 is reactivated in CAR T cells by Lareau, Caleb A., Yin, Yajie, Maurer, Katie, Sandor, Katalin D., Daniel, Bence, Yagnik, Garima, Peña, José, Crawford, Jeremy Chase, Spanjaart, Anne M., Gutierrez, Jacob C., Haradhvala, Nicholas J., Riberdy, Janice M., Abay, Tsion, Stickels, Robert R., Verboon, Jeffrey M., Liu, Vincent, Buquicchio, Frank A., Wang, Fangyi, Southard, Jackson, Song, Ren, Li, Wenjing, Shrestha, Aastha, Parida, Laxmi, Getz, Gad, Maus, Marcela V., Li, Shuqiang, Moore, Alison, Roberts, Zachary J., Ludwig, Leif S., Talleur, Aimee C., Thomas, Paul G., Dehghani, Houman, Pertel, Thomas, Kundaje, Anshul, Gottschalk, Stephen, Roth, Theodore L., Kersten, Marie J., Wu, Catherine J., Majzner, Robbie G., Satpathy, Ansuman T.

“…Cell therapies have yielded durable clinical benefits for patients with cancer, but the risks associated with the development of therapies from manipulated…”
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Immune Effector Cell-Associated Hemophagocytic Lymphohistiocytosis-Like Syndrome by Hines, Melissa R., Knight, Tristan E., McNerney, Kevin O., Leick, Mark B., Jain, Tania, Ahmed, Sairah, Frigault, Matthew J., Hill, Joshua A., Jain, Michael D., Johnson, William T., Lin, Yi, Mahadeo, Kris M., Maron, Gabriela M., Marsh, Rebecca A., Neelapu, Sattva S., Nikiforow, Sarah, Ombrello, Amanda K., Shah, Nirav N., Talleur, Aimee C., Turicek, David, Vatsayan, Anant, Wong, Sandy W., Maus, Marcela V., Komanduri, Krishna V., Berliner, Nancy, Henter, Jan-Inge, Perales, Miguel-Angel, Frey, Noelle V., Teachey, David T., Frank, Matthew J., Shah, Nirali N.

“…•Hemophagocytic lymphohistiocytosis (HLH)-like toxicities occur after CAR T-cells•This is now termed immune effector cell (IEC) associated HLH-like syndrome…”
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Limited Margin Radiation Therapy for Children and Young Adults With Ewing Sarcoma Achieves High Rates of Local Tumor Control by Talleur, Aimee C., MD, Navid, Fariba, MD, Spunt, Sheri L., MD, McCarville, M. Beth, MD, Wu, John, PhD, Mao, Shenghua, MS, Davidoff, Andrew M., MD, Neel, Michael D., MD, Krasin, Matthew J., MD

“…Purpose To determine the rate of local failure using focal conformal, limited margin radiation therapy (RT) and dose escalation for tumors ≥8 cm (greatest…”
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Thoughts from the threshold: patient and family hopes, fears, values, and goals at the onset of pediatric hematopoietic cell transplantation by Levine, Deena R., Van Noy, Kelsey, Talleur, Aimee C., Snyder, Angela, Kaye, Erica C., Baker, Justin N.

“…Hematopoietic cell transplantation (HCT) affords curative potential for high-risk patients but also carries risk of morbidity and mortality. Early palliative…”
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Development of a cGMP-compliant process to manufacture donor-derived, CD45RA-depleted memory CD19-CAR T cells by Kim-Hoehamer, Young-In, Riberdy, Janice M., Zheng, Fei, Park, Jeoungeun J., Shang, Na, Métais, Jean-Yves, Lockey, Timothy, Willis, Catherine, Akel, Salem, Moore, Jennifer, Meagher, Michael M., Velasquez, M. Paulina, Triplett, Brandon M., Talleur, Aimee C., Gottschalk, Stephen, Zhou, Sheng

“…Autologous chimeric antigen receptor (CAR) T cells targeting the CD19 antigen have demonstrated a high complete response rate in relapsed/refractory B-cell…”
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Infectious Complications in Pediatric, Adolescent and Young Adult Patients Undergoing CD19-CAR T Cell Therapy by Maron, Gabriela M, Hijano, Diego R, Epperly, Rebecca, Su, Yin, Tang, Li, Hayden, Randall T, Naik, Swati, Karol, Seth E, Gottschalk, Stephen, Triplett, Brandon M, Talleur, Aimee C

“…CD19-specific chimeric antigen receptor (CAR) T cell therapy has changed the treatment paradigm for pediatric, adolescent and young adult (AYA) patients with…”
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Extracorporeal Membrane Oxygenation Candidacy in Pediatric Patients Treated With Hematopoietic Stem Cell Transplant and Chimeric Antigen Receptor T-Cell Therapy: An International Survey by Ghafoor, Saad, Fan, Kimberly, Di Nardo, Matteo, Talleur, Aimee C, Saini, Arun, Potera, Renee M, Lehmann, Leslie, Annich, Gail, Wang, Fang, McArthur, Jennifer, Sandhu, Hitesh

“…Pediatric patients who undergo hematopoietic cell transplant (HCT) or chimeric antigen receptor T-cell (CAR-T) therapy are at high risk for complications…”
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Preferential expansion of CD8+ CD19-CAR T cells postinfusion and the role of disease burden on outcome in pediatric B-ALL by Talleur, Aimee C., Qudeimat, Amr, Métais, Jean-Yves, Langfitt, Deanna, Mamcarz, Ewelina, Crawford, Jeremy Chase, Huang, Sujuan, Cheng, Cheng, Hurley, Caitlin, Madden, Renee, Sharma, Akshay, Suliman, Ali, Srinivasan, Ashok, Velasquez, M. Paulina, Obeng, Esther A., Willis, Catherine, Akel, Salem, Karol, Seth E., Inaba, Hiroto, Bragg, Allison, Zheng, Wenting, Zhou, Sheng M., Schell, Sarah, Tuggle-Brown, MaCal, Cullins, David, Patil, Sagar L, Li, Ying, Thomas, Paul G., Zebley, Caitlin, Youngblood, Benjamin, Pui, Ching-Hon, Lockey, Timothy, Geiger, Terrence L., Meagher, Michael M., Triplett, Brandon M., Gottschalk, Stephen

“…•CD8+ CD19-CAR T cells outcompete their CD4+ counterparts and undergo antigen-driven differentiation after infusion.•Our study highlights the role of disease…”
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