Search Results - "Talbot, Pierre"

Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? by Desforges, Marc, Le Coupanec, Alain, Dubeau, Philippe, Bourgouin, Andréanne, Lajoie, Louise, Dubé, Mathieu, Talbot, Pierre J

“…Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. However, in vulnerable populations, such as newborns, infants, the…”
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Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43 by Dubé, Mathieu, Le Coupanec, Alain, Wong, Alan H M, Rini, James M, Desforges, Marc, Talbot, Pierre J

“…Human coronaviruses (HCoVs) are recognized respiratory pathogens for which accumulating evidence indicates that in vulnerable patients the infection can cause…”
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The human coronavirus HCoV-229E S-protein structure and receptor binding by Li, Zhijie, Tomlinson, Aidan Ca, Wong, Alan Hm, Zhou, Dongxia, Desforges, Marc, Talbot, Pierre J, Benlekbir, Samir, Rubinstein, John L, Rini, James M

“…The coronavirus S-protein mediates receptor binding and fusion of the viral and host cell membranes. In HCoV-229E, its receptor binding domain (RBD) shows…”
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Human coronaviruses: Viral and cellular factors involved in neuroinvasiveness and neuropathogenesis by Desforges, Marc, Le Coupanec, Alain, Stodola, Jenny K., Meessen-Pinard, Mathieu, Talbot, Pierre J.

“…•Human coronavirus (HCoV) are naturally neuroinvasive in both mice and humans.•Both transneuronal and hematogenous route may allow virus invasion of the…”
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The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology by Stodola, Jenny K., Dubois, Guillaume, Le Coupanec, Alain, Desforges, Marc, Talbot, Pierre J.

“…The OC43 strain of human coronavirus (HCoV-OC43) is an ubiquitous respiratory tract pathogen possessing neurotropic capacities. Coronavirus structural envelope…”
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Neuroinvasive and neurotropic human respiratory coronaviruses: potential neurovirulent agents in humans by Desforges, Marc, Le Coupanec, Alain, Brison, Elodie, Meessen-Pinard, Mathieu, Talbot, Pierre J

“…In humans, viral infections of the respiratory tract are a leading cause of morbidity and mortality worldwide. Several recognized respiratory viral agents have…”
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Receptor-binding loops in alphacoronavirus adaptation and evolution by Wong, Alan H. M., Tomlinson, Aidan C. A., Zhou, Dongxia, Satkunarajah, Malathy, Chen, Kevin, Sharon, Chetna, Desforges, Marc, Talbot, Pierre J., Rini, James M.

“…RNA viruses are characterized by a high mutation rate, a buffer against environmental change. Nevertheless, the means by which random mutation improves viral…”
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Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System by Le Coupanec, Alain, Desforges, Marc, Meessen-Pinard, Mathieu, Dubé, Mathieu, Day, Robert, Seidah, Nabil G, Talbot, Pierre J

“…Human coronaviruses (HCoV) are respiratory pathogens that may be associated with the development of neurological diseases, in view of their neuroinvasive and…”
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Pivotal Role of Receptor-Interacting Protein Kinase 1 and Mixed Lineage Kinase Domain-Like in Neuronal Cell Death Induced by the Human Neuroinvasive Coronavirus OC43 by Meessen-Pinard, Mathieu, Le Coupanec, Alain, Desforges, Marc, Talbot, Pierre J

“…Human coronaviruses (HCoV) are respiratory pathogens with neuroinvasive, neurotropic, and neurovirulent properties, highlighting the importance of studying the…”
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Human Coronavirus OC43 Associated with Fatal Encephalitis by Morfopoulou, Sofia, Brown, Julianne R, Davies, E. Graham, Anderson, Glenn, Virasami, Alex, Qasim, Waseem, Chong, Wui K, Hubank, Michael, Plagnol, Vincent, Desforges, Marc, Jacques, Thomas S, Talbot, Pierre J, Breuer, Judith

“…In this case report, severe encephalitis with no established cause developed in a child with SCID. Through deep sequencing, human coronavirus OC43 was…”
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Potential differences in cleavage of the S protein and type-1 interferon together control human coronavirus infection, propagation, and neuropathology within the central nervous system by Le Coupanec, Alain, Desforges, Marc, Kaufer, Benedikt, Dubeau, Philippe, Côté, Marceline, Talbot, Pierre J

“…Human coronaviruses (HCoV) are respiratory pathogens which have been known since the 1960's. In December 2019, a new betacoronavirus, SARS-CoV-2, was reported…”
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Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike by Prévost, Jérémie, Gasser, Romain, Beaudoin-Bussières, Guillaume, Richard, Jonathan, Duerr, Ralf, Laumaea, Annemarie, Anand, Sai Priya, Goyette, Guillaume, Benlarbi, Mehdi, Ding, Shilei, Medjahed, Halima, Lewin, Antoine, Perreault, Josée, Tremblay, Tony, Gendron-Lepage, Gabrielle, Gauthier, Nicolas, Carrier, Marc, Marcoux, Diane, Piché, Alain, Lavoie, Myriam, Benoit, Alexandre, Loungnarath, Vilayvong, Brochu, Gino, Haddad, Elie, Stacey, Hannah D., Miller, Matthew S., Desforges, Marc, Talbot, Pierre J., Maule, Graham T. Gould, Côté, Marceline, Therrien, Christian, Serhir, Bouchra, Bazin, Renée, Roger, Michel, Finzi, Andrés

“…SARS-CoV-2 is responsible for the coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds of thousands of deaths. The…”
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Safe and Sensitive Antiviral Screening Platform Based on Recombinant Human Coronavirus OC43 Expressing the Luciferase Reporter Gene by Shen, Liang, Yang, Yang, Ye, Fei, Liu, Gaoshan, Desforges, Marc, Talbot, Pierre J, Tan, Wenjie

“…Human coronaviruses (HCoVs) cause 15 to 30% of mild upper respiratory tract infections. However, no specific antiviral drugs are available to prevent or treat…”
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Novel Treatment with Neuroprotective and Antiviral Properties against a Neuroinvasive Human Respiratory Virus by Brison, Elodie, Jacomy, Hélène, Desforges, Marc, Talbot, Pierre J

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The Acetyl-Esterase Activity of the Hemagglutinin-Esterase Protein of Human Coronavirus OC43 Strongly Enhances the Production of Infectious Virus by Desforges, Marc, Desjardins, Jessica, Zhang, Chengsheng, Talbot, Pierre J

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Human Coronavirus-Induced Neuronal Programmed Cell Death Is Cyclophilin D Dependent and Potentially Caspase Dispensable by Favreau, Dominique J, Meessen-Pinard, Mathieu, Desforges, Marc, Talbot, Pierre J

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Glutamate Excitotoxicity Is Involved in the Induction of Paralysis in Mice after Infection by a Human Coronavirus with a Single Point Mutation in Its Spike Protein by BRISON, Elodie, JACOMY, Hélène, DESFORGES, Marc, TALBOT, Pierre J

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Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on α4 integrin by Ifergan, Igal, Kebir, Hania, Alvarez, Jorge I., Marceau, Gabriel, Bernard, Monique, Bourbonnière, Lyne, Poirier, Josée, Duquette, Pierre, Talbot, Pierre J., Arbour, Nathalie, Prat, Alexandre

“…Clonally expanded CD8+ T lymphocytes are present in multiple sclerosis lesions, as well as in the cerebrospinal fluid of patients with multiple sclerosis. In…”
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Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication by CENCIC, Regina, DESFORGES, Marc, PELLETIER, Jerry, HALL, David R, KOZAKOV, Dima, YUHONG DU, MIN, Jaeki, DINGLEDINE, Raymond, HAIAN FU, VAJDA, Sandor, TALBOT, Pierre J

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Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae by Anderson, Danielle E, Pfeffermann, Kristin, Kim, So Young, Sawatsky, Bevan, Pearson, James, Kovtun, Mikhail, Corcoran, David L, Krebs, Yvonne, Sigmundsson, Kristmundur, Jamison, Sharon F, Yeo, Zhen Zhen Joanna, Rennick, Linda J, Wang, Lin-Fa, Talbot, Pierre J, Duprex, W Paul, Garcia-Blanco, Mariano A, von Messling, Veronika

“…Paramyxoviruses and pneumoviruses have similar life cycles and share the respiratory tract as a point of entry. In comparative genome-scale siRNA screens with…”
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