Search Results - "Talbot, P A"

Asymmetric Palladium-Catalyzed Directed Intermolecular Fluoroarylation of Styrenes by Talbot, Eric P. A, Fernandes, Talita de A, McKenna, Jeffrey M, Toste, F. Dean

“…A mild catalytic asymmetric direct fluoro-arylation of styrenes has been developed. The palladium-catalyzed three-component coupling of Selectfluor, a styrene…”
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Transition-Metal-Free Amine Oxidation: A Chemoselective Strategy for the Late-Stage Formation of Lactams by Griffiths, Robert J, Burley, Glenn A, Talbot, Eric P. A

“…A metal-free strategy for the formation of lactams via selective oxidation of cyclic secondary and tertiary amines is described. Molecular iodine facilitates…”
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The development and mechanistic investigation of a palladium-catalyzed 1,3-arylfluorination of chromenes by Thornbury, Richard T, Saini, Vaneet, Fernandes, Talita de A, Santiago, Celine B, Talbot, Eric P A, Sigman, Matthew S, McKenna, Jeffrey M, Toste, F Dean

“…A mild palladium-catalyzed ligand-controlled regioselective 1,3-arylfluorination of 2[ ]-chromenes has been developed. The products with a -1,3 substitution…”
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One-Pot, Three-Step Synthesis of Cyclopropylboronic Acid Pinacol Esters from Synthetically Tractable Propargylic Silyl Ethers by Spencer, Jonathan A, Jamieson, Craig, Talbot, Eric P. A

“…Simple propargylic silyl ethers can be converted to complex cyclopropylboronic acid pinacol esters in an efficient one-pot procedure. Terminal acetylenes…”
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Copper-Catalyzed Synthesis of Activated Sulfonate Esters from Boronic Acids, DABSO, and Pentafluorophenol by Vedovato, Vincent, Talbot, Eric P. A, Willis, Michael C

“…The synthesis of pentafluorophenyl (PFP) sulfonate esters based on the Pd-catalyzed sulfination of aryl and heteroaryl boronic acids is reported. The sulfinate…”
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Catalytic Asymmetric Synthesis of (+)-Anthecotulide Using Enyne and Meyer–Schuster Rearrangements by Hodgson, David M, Talbot, Eric P. A, Clark, Barry P

“…The bioactive sesquiterpene lactone (+)-anthecotulide (1) is synthesized for the first time, in a six-step sequence devoid of protecting groups. The key…”
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Gold-Catalyzed Redox Synthesis of Imidazo[1,2-a]pyridines using Pyridine N-Oxide and Alkynes by Talbot, Eric P. A., Richardson, Melodie, McKenna, Jeffrey M., Toste, F. Dean

“…A mild, catalytic, atom economical synthesis of imidazo[1,2‐a]pyridines has been developed: catalytic dichloro(2‐pyridinecarboxylato)gold [PicAuCl2] in the…”
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Stereoselective Synthesis of β-(Hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones by Hodgson, David M, Talbot, Eric P. A, Clark, Barry P

“…Zinc or a chromium(II) source with 3-(bromomethyl)furan-2(5H)-one (3) and an aldehyde gives β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones 5 in good…”
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Oxidative β-C-H sulfonylation of cyclic amines by Griffiths, R J, Kong, W C, Richards, S A, Burley, G A, Willis, M C, Talbot, E P A

“…A transition metal-free strategy for the dehydrogenative β-sulfonylation of tertiary cyclic amines is described. -Iodosuccinimide facilitates regioselective…”
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Regioselective Synthesis of Fully Substituted Fused Pyrroles through an Oxidant-Free Multicomponent Reaction by Afratis, Konstantinos, Bateman, Joseph M., Rahemtulla, Benjamin F., Hughes, Oliver, Milgram, Benjamin C., Mulhern, Thomas A., Talbot, Eric P. A.

“…The synthesis of fully substituted fused pyrroles through a multicomponent reaction between a thioamide, an aldehyde, and ammonium acetate is described. This…”
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Hydrogen Atom Transfer‐Mediated Cyclisations of Nitriles by Turner, Oliver J., Murphy, John A., Hirst, David J., Talbot, Eric P. A.

“…Hydrogen atom transfer‐mediated intramolecular C−C coupling reactions between alkenes and nitriles, using PhSiH3 and catalytic Fe(acac)3, are described. This…”
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Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator by Thomson, Christopher G., Aicher, Thomas D., Cheng, Weiwei, Du, Hongwen, Dudgeon, Crissy, Li, An-Hu, Li, Baozhong, Lightcap, Eric, Luo, Diheng, Mulvihill, Mark, Pan, Pengwei, Rahemtulla, Benjamin F., Rigby, Alan C., Sherborne, Bradley, Sood, Sanjeev, Surguladze, David, Talbot, Eric P. A., Tameire, Feven, Taylor, Simon, Wang, Yi, Wojnarowicz, Paulina, Xiao, Fenfen, Ramurthy, Savithri

“…A series of activators of GCN2 (general control nonderepressible 2) kinase have been developed, leading to HC-7366, which has entered the clinic as an…”
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Gold Catalysed Redox Synthesis of Imidazo[1,2- a ]pyridine using Pyridine N -Oxide and Alkynes by Talbot, Eric P A, Richardson, Melodie, McKenna, Jeffrey M, Toste, F Dean

“…A mild, catalytic, atom economical synthesis of imidazo[1,2- ]pyridines has been developed: catalytic PicAuCl in the presence of an acid produces a range…”
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Potentiation of aminoglycoside-induced neuromuscular blockade by protons in vitro and in vivo by Talbot, P A

“…pH-dependent effects of 100 microM streptomycin and various aminoglycosides were examined at frog (Rana pipiens pipiens) sciatic sartorii in vitro by using the…”
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Nature of increase in quantal release by the thallous ion at frog end plates with and without nerve stimulation by TALBOT, P. A

“…The monovalent thallous ion (Tl) was evaluated at the frog end plate in vitro with intracellular microelectrodes. Recordings included end plate potentials…”
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Effects of primidone, phenobarbital and phenylethylmalonamide in the stimulated frog neuromuscular junction by Talbot, P A, Alderdice, M T

“…The effects of primidone (1.0 mM), phenobarbital (0.2 mM) and phenylethylmalonamide (PEMA) (1.0 mM) on nerve-stimulated transmitter release (quantal content)…”
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Primidone but not phenylethylmalonamide, a major metabolite, increases nerve-evoked transmitter release at the frog neuromuscular junction by Talbot, P A, Alderdice, M T

“…The fundamental responses of primidone and phenylethylmalonamide (PEMA), a major metabolite, were investigated electrophysiologically at the frog (Rana…”
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Kilogram-Scale Synthesis of 11β-Hydroxyandrosterone by Abas, Hossay, Blencowe, Peter, MacDonald, Ellen, Stanway, Emma, Talbot, Eric P. A., Wang, Haiyang, Watson, Morag, Zhang, Jin, Harwood, Lucy A.

“…This article describes a robust and large-scale synthesis of the ketosteroid building block 11β-hydroxyandrosterone (2) from cheap and readily available…”
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Conceptualisation and Experiences of Engaged Citizenship as Critical Consciousness, Transformative Education and Mutual Joy: An Autoethnography by Talbot, A. L. P., Mccann, C.

“…In recent years, higher education institutions globally and in South Africa have begun to focus more on the educational potential of community-university…”
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Protons resolve dual effects of calcium on miniature end-plate potential frequency at frog neuromuscular junctions by TALBOT, P. A

“…Inhibition of transmitter release by protons (H+) was studied at the frog neuromuscular junction at various extracellular concentrations of calcium ([Ca++]o)…”
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