Search Results - "Talbert, Erin E"

Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle by Powers, Scott K., Talbert, Erin E., Adhihetty, Peter J.

“…It is well established that contracting skeletal muscles produce free radicals. Given that radicals are known to play a prominent role in the pathogenesis of…”
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Impaired regeneration: A role for the muscle microenvironment in cancer cachexia by Talbert, Erin E., Guttridge, Denis C.

“…While changes in muscle protein synthesis and degradation have long been known to contribute to muscle wasting, a body of literature has arisen which suggests…”
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Crosstalk between autophagy and oxidative stress regulates proteolysis in the diaphragm during mechanical ventilation by Smuder, Ashley J., Sollanek, Kurt J., Nelson, W. Bradley, Min, Kisuk, Talbert, Erin E., Kavazis, Andreas N., Hudson, Matthew B., Sandri, Marco, Szeto, Hazel H., Powers, Scott K.

“…Mechanical ventilation (MV) results in the rapid development of ventilator-induced diaphragm dysfunction (VIDD). While the mechanisms responsible for VIDD are…”
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Reactive oxygen species are signalling molecules for skeletal muscle adaptation by Powers, Scott K., Duarte, Jose, Kavazis, Andreas N., Talbert, Erin E.

“…Increased reactive oxygen species (ROS) production is crucial to the remodelling that occurs in skeletal muscle in response to both exercise training and…”
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Inflammation as a Therapeutic Target in Cancer Cachexia by Clamon, Gerald, Byrne, Margaret M, Talbert, Erin E

“…Cachexia is a common complication of cancer and is associated with poor quality of life and a decrease in survival. Many patients with cancer cachexia suffer…”
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MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB by Shintaku, Jonathan, Peterson, Jennifer M., Talbert, Erin E., Gu, Jin-Mo, Ladner, Katherine J., Williams, Dustin R., Mousavi, Kambiz, Wang, Ruoning, Sartorelli, Vittorio, Guttridge, Denis C.

“…MyoD is a key regulator of skeletal myogenesis that directs contractile protein synthesis, but whether this transcription factor also regulates skeletal muscle…”
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Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness by Powers, Scott K, Hudson, Matthew B, Nelson, W. Bradley, Talbert, Erin E, Min, Kisuk, Szeto, Hazel H, Kavazis, Andreas N, Smuder, Ashley J

“…BACKGROUND:Mechanical ventilation is a life-saving intervention used to provide adequate pulmonary ventilation in patients suffering from respiratory failure…”
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Optimization of a mouse model of pancreatic cancer to simulate the human phenotypes of metastasis and cachexia by Spadafora, Victoria, Pryce, Benjamin R, Oles, Alexander, Talbert, Erin E, Romeo, Martin, Vaena, Silvia, Berto, Stefano, Ostrowski, Michael C, Wang, David J, Guttridge, Denis C

“…Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is…”
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Calpain and caspase-3 play required roles in immobilization-induced limb muscle atrophy by Talbert, Erin E, Smuder, Ashley J, Min, Kisuk, Kwon, Oh Sung, Powers, Scott K

“…Prolonged skeletal muscle inactivity results in a rapid decrease in fiber size, primarily due to accelerated proteolysis. Although several proteases are known…”
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Predictors of Pancreatic Cancer-Associated Weight Loss and Nutritional Interventions by Nemer, Laura, Krishna, Somashekar G, Shah, Zarine K, Conwell, Darwin L, Cruz-Monserrate, Zobeida, Dillhoff, Mary, Guttridge, Denis C, Hinton, Alice, Manilchuk, Andrei, Pawlik, Timothy M, Schmidt, Carl R, Talbert, Erin E, Bekaii-Saab, Tanios, Hart, Phil A

“…Pancreatic ductal adenocarcinoma (PDAC) is often accompanied by weight loss. We sought to characterize factors associated with weight loss and observed…”
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Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production by Kavazis, Andreas N., Talbert, Erin E., Smuder, Ashley J., Hudson, Matthew B., Nelson, W. Bradley, Powers, Scott K.

“…Mechanical ventilation (MV) is a life-saving intervention used in patients with acute respiratory failure. Unfortunately, prolonged MV results in diaphragmatic…”
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Muscle inflammation is regulated by NF-κB from multiple cells to control distinct states of wasting in cancer cachexia by Pryce, Benjamin R., Oles, Alexander, Talbert, Erin E., Romeo, Martin J., Vaena, Silvia, Sharma, Sudarshana, Spadafora, Victoria, Tolliver, Lauren, Mahvi, David A., Morgan, Katherine A., Lancaster, William P., Beal, Eryn, Koren, Natlie, Watts, Bailey, Overstreet, Morgan, Berto, Stefano, Subramanian, Suganya, Calisir, Kubra, Crawford, Anna, Neelon, Brian, Ostrowski, Michael C., Zimmers, Teresa A., Tidball, James G., Wang, David J., Guttridge, Denis C.

“…Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with…”
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Protection against Doxorubicin-Induced Cardiac Dysfunction Is Not Maintained Following Prolonged Autophagy Inhibition by Montalvo, Ryan N, Doerr, Vivian, Kwon, Oh Sung, Talbert, Erin E, Yoo, Jeung-Ki, Hwang, Moon-Hyon, Nguyen, Branden L, Christou, Demetra D, Kavazis, Andreas N, Smuder, Ashley J

“…Doxorubicin (DOX) is a highly effective chemotherapeutic agent used in the treatment of various cancer types. Nevertheless, it is well known that DOX promotes…”
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Circulating monocyte chemoattractant protein‐1 (MCP‐1) is associated with cachexia in treatment‐naïve pancreatic cancer patients by Talbert, Erin E., Lewis, Heather L., Farren, Matthew R., Ramsey, Mitchell L., Chakedis, Jeffery M., Rajasekera, Priyani, Haverick, Ericka, Sarna, Angela, Bloomston, Mark, Pawlik, Timothy M., Zimmers, Teresa A., Lesinski, Gregory B., Hart, Phil A., Dillhoff, Mary E., Schmidt, Carl R., Guttridge, Denis C.

“…Background Cancer‐associated wasting, termed cancer cachexia, has a profound effect on the morbidity and mortality of cancer patients but remains difficult to…”
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Modeling human cancer cachexia in colon 26 tumor-bearing adult mice by Talbert, Erin E., Metzger, Gregory A., He, Wei A., Guttridge, Denis C.

“…Background Muscle wasting is a profound side effect of advanced cancer. Cancer-induced cachexia decreases patient quality of life and is associated with poor…”
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Prevention of Doxorubicin-Induced Autophagy Attenuates Oxidative Stress and Skeletal Muscle Dysfunction by Doerr, Vivian, Montalvo, Ryan N, Kwon, Oh Sung, Talbert, Erin E, Hain, Brian A, Houston, Fraser E, Smuder, Ashley J

“…Clinical use of the chemotherapeutic doxorubicin (DOX) promotes skeletal muscle atrophy and weakness, adversely affecting patient mobility and strength…”
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Blockage of the Ryanodine Receptor via Azumolene Does Not Prevent Mechanical Ventilation-Induced Diaphragm Atrophy by Talbert, Erin E, Smuder, Ashley J, Kwon, Oh Sung, Sollanek, Kurt J, Wiggs, Michael P, Powers, Scott K

“…Mechanical ventilation (MV) is a life-saving intervention for patients in respiratory failure. However, prolonged MV causes the rapid development of diaphragm…”
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Identification of circulating plasma ceramides as a potential sexually dimorphic biomarker of pancreatic cancer‐induced cachexia by Chakedis, Jeffery M., Dillhoff, Mary E., Schmidt, Carl R., Rajasekera, Priyani V., Evans, David C., Williams, Terence M., Guttridge, Denis C., Talbert, Erin E.

“…Background Cancer patients who exhibit cachexia lose weight and have low treatment tolerance and poor outcomes compared with cancer patients without weight…”
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Emerging signaling mediators in the anorexia-cachexia syndrome of cancer by Talbert, Erin E, Guttridge, Denis C

“…The cachexia syndrome in cancer is characterized by weight loss resulting from the combination of anorexia and atrophy of adipose and skeletal muscle. For…”
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The effects of enalapril and losartan on mechanical ventilation–induced sympathoadrenal activation and oxidative stress in rats by Toklu, Hale Zerrin, PhD, Kwon, Oh-Sung, PhD, Sakarya, Yasemin, Powers, Scott K., PhD, Llinas, Katherine, Kirichenko, Nataliya, MSc, Sollanek, Kurt J., MSc, Wiggs, Michael P., PhD, Smuder, Ashley J., PhD, Talbert, Erin E., PhD, Scarpace, Philip J., PhD, Tümer, Nihal, PhD

“…Abstract Background Mechanical ventilation (MV) is a method of maintaining appropriate gas exchange in patients who are unable to sustain adequate alveolar…”
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