Search Results - "Tala, Srinivasa R."

Design, Synthesis, and Structure−Activity Relationship of a Novel Series of 2-Aryl 5-(4-Oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl)furans as HIV-1 Entry Inhibitors by Katritzky, Alan R, Tala, Srinivasa R, Lu, Hong, Vakulenko, Anatoliy V, Chen, Qi-Yin, Sivapackiam, Jothilingam, Pandya, Keyur, Jiang, Shibo, Debnath, Asim K

“…We previously identified two small molecules targeting the HIV-1 gp41, N-(4-carboxy-3-hydroxy)phenyl-2,5-dimethylpyrrole 12 (NB-2) and…”
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Design, Synthesis, and Biological Activity of Novel 5-((Arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones as HIV-1 Fusion Inhibitors Targeting gp41 by Jiang, Shibo, Tala, Srinivasa R, Lu, Hong, Abo-Dya, Nader E, Avan, Ilker, Gyanda, Kapil, Lu, Lu, Katritzky, Alan R, Debnath, Asim K

“…On the basis of our earlier molecular docking analysis, we designed and synthesized…”
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Regioselective synthesis and molecular modeling study of vasorelaxant active 7,9-dioxa-1,2-diaza-spiro[4.5]dec-2-ene-6,10-diones by Girgis, Adel S., Ismail, Nasser S.M., Farag, Hanaa, El-Eraky, Wafaa I., Saleh, Dalia O., Tala, Srinivasa R., Katritzky, Alan R.

“…Nitrilimines (PhC −:N +:NR′) generated in situ from hydrazonoyl chlorides 2a,b reacted regioselectively with 5-arylidene-2,2-dimethyl[1,3]dioxane-4,6-diones…”
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Microwave-assisted solid-phase synthesis of side-chain to side-chain lactam-bridge cyclic peptides by Tala, Srinivasa R., Schnell, Sathya M., Haskell-Luevano, Carrie

“…[Display omitted] Side-chain to side-chain lactam-bridged cyclic peptides have been utilized as therapeutic agents and biochemical tools. Previous synthetic…”
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Synthesis and Pharmacology of α/β(3)-Peptides Based on the Melanocortin Agonist Ac-His-dPhe-Arg-Trp-NH2 Sequence by Singh, Anamika, Tala, Srinivasa R, Flores, Viktor, Freeman, Katie, Haskell-Luevano, Carrie

“…The melanocortin-3 and -4 receptors are expressed in the brain and play key roles in regulating feeding behavior, metabolism, and energy homeostasis. In the…”
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1,2,3-Triazole Rings as a Disulfide Bond Mimetic in Chimeric AGRP-Melanocortin Peptides: Design, Synthesis, and Functional Characterization by Tala, Srinivasa R, Singh, Anamika, Lensing, Cody J, Schnell, Sathya M, Freeman, Katie T, Rocca, James R, Haskell-Luevano, Carrie

“…The melanocortin system is involved in the regulation of complex physiological functions, including energy and weight homeostasis, feeding behavior,…”
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Benzotriazole-Mediated Syntheses of Depsipeptides and Oligoesters by Avan, Ilker, Tala, Srinivasa R, Steel, Peter J, Katritzky, Alan R

“…Reactions of O-Pg(α-hydroxyacyl)benzotriazoles with (a) unprotected α-hydroxycarboxylic acids, (b) amino acids, and (c) amines afforded, respectively, chirally…”
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Efficient Preparation of Aminoxyacyl Amides, Aminoxy Hybrid Peptides, and α-Aminoxy Peptides by Katritzky, Alan R, Avan, Ilker, Tala, Srinivasa R

“…N-(Pg-α-aminoxy acids) 1a−g are converted to N-(Pg-α-aminoxyacyl)benzotriazoles 2a−g, which react under mild conditions with amines, α-amino…”
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Human β‑Defensin 1 and β‑Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors by Ericson, Mark D, Singh, Anamika, Tala, Srinivasa R, Haslach, Erica M, Dirain, Marvin L. S, Schaub, Jay W, Flores, Viktor, Eick, Natalie, Lensing, Cody J, Freeman, Katie T, Smeester, Branden A, Adank, Danielle N, Wilber, Stacey L, Speth, Robert, Haskell-Luevano, Carrie

“…β-Defensin 3 (BD3) was identified as a ligand for the melanocortin receptors (MCRs) in 2007, although the pharmacology activity of BD3 has not been clearly…”
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Computer-assisted rational design, synthesis, and bioassay of non-steroidal anti-inflammatory agents by Girgis, Adel S., Tala, Srinivasa R., Oliferenko, Polina V., Oliferenko, Alexander A., Katritzky, Alan R.

“…A focused dataset of previously synthesized and tested [1,2,4]-triazolo[1,5-a]pyridines and pyridine-3-carboxylates was studied by Molecular Field Topology…”
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Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41 by Jiang, Shibo, Tala, Srinivasa R., Lu, Hong, Zou, Peng, Avan, Ilker, Ibrahim, Tarek S., Abo-Dya, Nader E., Abdelmajeid, Abdelmotaal, Debnath, Asim K., Katritzky, Alan R.

“…Based on molecular docking analysis of earlier results, we designed a series of 2,5-disubstituted furans/pyrroles ( 5a– h) as HIV-1 entry inhibitors. Compounds…”
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QSAR modeling, synthesis and bioassay of diverse leukemia RPMI-8226 cell line active agents by Katritzky, Alan R., Girgis, Adel S., Slavov, Svetoslav, Tala, Srinivasa R., Stoyanova-Slavova, Iva

“…A rigorous QSAR modeling procedure employing CODESSA PRO descriptors has been utilized for the prediction of more efficient anti-leukemia agents. Experimental…”
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Preparation and characterization of 1,2,3-triazole-cured polymers from endcapped azides and alkynes by Katritzky, Alan R, Meher, Nabin K, Hanci, Sureyya, Gyanda, Reena, Tala, Srinivasa R, Mathai, Sindhu, Duran, Randolph S, Bernard, Sophie, Sabri, Firouzeh, Singh, Sandeep K, Doskocz, Jacek, Ciaramitaro, David A

“…Fourteen commercial polyols have been characterized by GPC, NMR spectroscopy, and elemental analysis. From these, eight corresponding tosylates, six nitrate…”
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Synthesis and Pharmacology of α/β3‑Peptides Based on the Melanocortin Agonist Ac-His‑dPhe-Arg-Trp-NH2 Sequence by Singh, Anamika, Tala, Srinivasa R, Flores, Viktor, Freeman, Katie, Haskell-Luevano, Carrie

“…The melanocortin-3 and -4 receptors are expressed in the brain and play key roles in regulating feeding behavior, metabolism, and energy homeostasis. In the…”
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Chemical Ligation of S-Scylated Cysteine Peptides to Form Native Peptides via 5-, 11-, and 14-Membered Cyclic Transition States by Katritzky, Alan R, Tala, Srinivasa R, Abo-Dya, Nader E, Ibrahim, Tarek S, El-Feky, Said A, Gyanda, Kapil, Pandya, Keyur M

“…Cysteine-containing dipeptides 3a−l, (3b+3b′) (compound numbers in parentheses are used to indicate racemic mixtures; thus (3b+3b′) is the racemate of 3b and…”
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The chemical ligation of selectively S-acylated cysteine peptides to form native peptides via 5-, 11- and 14-membered cyclic transition states by Katritzky, Alan R, Abo-Dya, Nader E, Tala, Srinivasa R, Abdel-Samii, Zakaria K

“…Cysteine and C-terminal cysteine peptides are selectively S-acylated at 0-20 degrees C by N-(Pg-alpha-aminoacyl)benzotriazoles to give N-Pg-S-acyl-isodi-,…”
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Selective Synthesis and Structural Elucidation of S-Acyl- and N-Acylcysteines by Katritzky, Alan R, Tala, Srinivasa R, Abo-Dya, Nader E, Gyanda, Kapil, El-Gendy, Bahaa El-Dien M, Abdel-Samii, Zakaria K, Steel, Peter J

“…N-(Acyl)-1H-benzotriazoles 6a−f react with l-cysteine 5 at 20 °C to give exclusively (i) N-acyl-l-cysteines 8a−e in the presence of triethylamine in CH3CN−H2O…”
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DBU-catalyzed transprotection of N-Fmoc-cysteine di- and tripeptides into S-Fm-cysteine di- and tripeptides by Katritzky, Alan R, Abo-Dya, Nader E, Abdelmajeid, Abdelmotaal, Tala, Srinivasa R, Amine, M S, El-Feky, Said A

“…The transprotection of N-Fmoc-cysteine containing di- and tripeptides possessing a free SH group to produce the corresponding S-Fm-cysteine di- and tripeptides…”
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Convenient and Efficient Preparations of Azodye-Labeled Peptides by Katritzky, Alan R, Chen, Qi-Yin, Tala, Srinivasa R

“…N-(4-Arylazobenzoyl)-1H-benzotriazoles 15a, 15b react with dipeptides 12a-d, (12d+12d') and tripeptides 14a, 14b to give azodye labeled-dipeptides (16a-e),…”
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Efficient preparation of azodye-labeled aminoxy acids and peptides by Biswas, Suvendu, Tala, Srinivasa R., Kalatozishvili, Akaki, Katritzky, Alan R.

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