Search Results - "Tal, D M"

Extensive digestion of Na+,K(+)-ATPase by specific and nonspecific proteases with preservation of cation occlusion sites by Capasso, J M, Hoving, S, Tal, D M, Goldshleger, R, Karlish, S J

“…This paper extends our recent report that renal Na+,K(+)-ATPase is digested by trypsin in the absence of Ca2+ and presence of Rb+ ions to a stable 19-kDa…”
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Chemical Modification of Glu-953 of the α Chain of Na+,K+- ATPase Associated with Inactivation of Cation Occlusion by Goldshleger, R., Tal, D. M., Moorman, J., Stein, W. D., Karlish, S. J. D.

“…We have investigated the role, number, and identity of glutamate (or aspartate) residues involved in cation occlusion on Na+,K+-ATPase, using the carboxyl…”
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Effects of competitive sodium-like antagonists on Na,K-ATPase suggest that cation occlusion from the cytoplasmic surface occurs in two steps by OR, E, DAVID, P, SHAINSKAYA, A, TAL, D. M, KARLISH, J. D

“…Information on cation occlusion sites of renal NA,K-ATPase has been obtained by comparing the ability of competitive Na-like antagonists (David, P., Mayan, H.,…”
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Guanidinium derivatives act as high affinity antagonists of Na+ ions in occlusion sites of Na+,K(+)-ATPase by David, P, Mayan, H, Cohen, H, Tal, D M, Karlish, S J

“…We have screened various alkyl- and arylguanidinium derivatives as possible competitors of Na+ or Rb+ for the cation sites on renal Na+,K(+)-ATPase…”
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Inhibition of amiloride-sensitive Na+ channel by isothiouronium derivatives by Avigdor, A, Asher, C, Tal, D M, Karlish, S J, Garty, H

“…The effects on the amiloride-blockable Na+ channel of a family of recently synthesized isothiouronium derivatives were measured in plasma membrane vesicles…”
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Do canrenone and 6,7-dihydroxylated derivatives compete with ouabain at the same site on Na,K-ATPase? by Tal, D M, Karlish, S J

“…Canrenone is the major metabolic product of the synthetic steroids spironolactone and K+-canrenoate, used in antihypertensive therapy. Canrenone can…”
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Separation of membrane-embedded tryptic peptides of Na,K-ATPase by size-exclusion chromatography by Tal, D M, Goldshleger, R, Karlish, S J

“…Several attempts to separate hydrophobic tryptic and cyanogen bromide-digested short peptides from Na,K-ATPase, using HPLC and different acid-organic solvent…”
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Inactivation of Rb+ and Na+ occlusion on (Na+,K+)-ATPase by modification of carboxyl groups by Shani-Sekler, M, Goldshleger, R, Tal, D M, Karlish, S J

“…This paper demonstrates and characterizes inactivation by N,N′-dicyclohexylcarbodiimide (DCCD) of Rb+ and Na+ occlusion in pig kidney (Na+,K+)-ATPase. Rb+ and…”
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Identification of Na+/K+-ATPase inhibitors in bovine plasma as fatty acids and hydrocarbons by Tal, D M, Yanuck, M D, van Hall, G, Karlish, S J

“…A preparative purification of endogenous inhibitors of the Na+/K+-ATPase has been carried out from bovine blood. Dried plasma was deproteinized,…”
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Topology of the .alpha.-Subunit of Na,K-ATPase Based on Proteolysis. Lability of the Topological Organization by Goldshleger, Rivka, Tal, Daniel M, Karlish, Steven J. D

“…Topology of the alpha-subunit of Na,K-ATPase has been analyzed utilizing proteolytic digestion. Evidence is presented for a model with 10 transmembrane…”
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Structural organization and energy transduction mechanism of Na+,K+-ATPase studied with transition metal-catalyzed oxidative cleavage by Goldshleger, R, Patchornik, G, Shimon, M B, Tal, D M, Post, R L, Karlish, S J

“…This chapter describes contributions of transition metal-catalyzed oxidative cleavage of Na+,K+-ATPase to our understanding of structure-function relations. In…”
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Proximity of Transmembrane Segments M3 and M1 of the α Subunit of Na+,K+-ATPase Revealed by Specific Oxidative Cleavage Mediated by a Complex of Cu2+ Ions and 4,7-Diphenyl-1,10-phenanthroline by Tal, Daniel M, Capasso, Juan M, Munson, Keith, Karlish, Steven J. D

“…This paper describes a novel approach to specific oxidative cleavage of Na+,K+-ATPase, mediated by Cu2+ ions and a hydrophobic phenanthroline,…”
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Solubilization of a Complex of Tryptic Fragments of Na,K-ATPase Containing Occluded Rb Ions and Bound Ouabain by Or, Eran, Goldshleger, Rivka, Tal, Daniel M, Karlish, Steven J. D

“…The nonionic detergent C12E10 (polyoxyethylene 10-laurylether) has been used to solubilize a complex of tryptic fragments of Na,K-ATPase containing occluded Rb…”
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Mortality in the Oldest-Old Adults After Discharge From Acute Geriatric Ward by Tal, Sari

“…Aim: To examine risk factors for post-discharge mortality in the oldest-old patients. Methods: We have assessed the risk factors for mortality after discharge…”
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Heart Failure After Myocardial Infarction Is Associated With Increased Risk of Cancer by Hasin, Tal, MD, Gerber, Yariv, PhD, Weston, Susan A., MS, Jiang, Ruoxiang, BS, Killian, Jill M., BS, Manemann, Sheila M., MPH, Cerhan, James R., MD, PhD, Roger, Véronique L., MD

“…Abstract Background Heart failure (HF) is associated with excess morbidity and mortality for which noncardiac causes are increasingly recognized. The authors…”
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6,7-Dihydroxy-6,7-dihydrocanrenone isomers: improved synthesis and proton NMR study by Tal, D M

“…The synthesis in improved yields of one 6,7-epoxide and three 6,7-dihydroxycanrenone derivatives is described. Canrenone was the starting material for all…”
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Novel Aromatic Isothiouronium Derivatives Which Act as High Affinity Competitive Antagonists of Alkali Metal Cations on Na/K-ATPase (∗) by Hoving, Sjouke, Bar-Shimon, Meirav, Tijmes, Jolanda J., Goldshleger, Rivka, Tal, Daniel M., Karlish, Steven J.D.

“…This paper describes properties of a novel family of aromatic isothiouronium derivatives, which act as Na+-like competitive antagonists on renal Na/K-ATPase…”
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Recommendations for Quantification Methods During the Performance of a Pediatric Echocardiogram: A Report From the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council by Lopez, Leo, MD, FASE, Chair, Colan, Steven D., MD, FASE, Frommelt, Peter C., MD, FASE, Ensing, Gregory J., MD, FASE, Kendall, Kathleen, RDCS, FASE, Younoszai, Adel K., MD, FASE, Lai, Wyman W., MD, MPH, FASE, Geva, Tal, MD, FASE

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Imaging Criteria for Arrhythmogenic Right Ventricular Cardiomyopathy by Geva, Tal, MD

“…[...]the rTFC threshold values of RV volumes and ejection fractions should be re-evaluated based on comparison between a large cohort of ARVC probands with a…”
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Associated Risk of Malignancy in Patients with Cardiovascular Disease: Evidence and Possible Mechanism by Hasin, Tal, MD, Iakobishvili, Zaza, MD, Weisz, Giora, MD

“…Abstract Cardiovascular disease and malignancy are leading causes of morbidity and mortality. Increased risk of malignancy was identified in patients with…”
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