Search Results - "Takumi, Toru"

Postsynaptic density proteins and their involvement in neurodevelopmental disorders by Kaizuka, Takeshi, Takumi, Toru

“…Synaptic connections are essential for neural circuits in order to convey brain functions. The postsynaptic density (PSD) is a huge protein complex associated…”
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Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness by Nishita, Michiru, Park, Seung-Yeol, Nishio, Tadashi, Kamizaki, Koki, Wang, ZhiChao, Tamada, Kota, Takumi, Toru, Hashimoto, Ryuju, Otani, Hiroki, Pazour, Gregory J., Hsu, Victor W., Minami, Yasuhiro

“…Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as…”
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Genomic and genetic aspects of autism spectrum disorder by Liu, Xiaoxi, Takumi, Toru

“…•Genetic abnormality for autism spectrum disorder (ASD) is overviewed.•Genomic abnormality for ASD including copy number variation is summarized.•Genome-wide…”
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The choroid plexus is an important circadian clock component by Myung, Jihwan, Schmal, Christoph, Hong, Sungho, Tsukizawa, Yoshiaki, Rose, Pia, Zhang, Yong, Holtzman, Michael J., De Schutter, Erik, Herzel, Hanspeter, Bordyugov, Grigory, Takumi, Toru

“…Mammalian circadian clocks have a hierarchical organization, governed by the suprachiasmatic nucleus (SCN) in the hypothalamus. The brain itself contains…”
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Molecular signatures from multi‐omics of autism spectrum disorders and schizophrenia by Nomura, Jun, Mardo, Matthew, Takumi, Toru

“…The genetic and phenotypic heterogeneity of autism spectrum disorder (ASD) impedes the unification of multiple biological hypotheses in an attempt to explain…”
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Unusual semi‐extractability as a hallmark of nuclear body‐associated architectural noncoding RNAs by Chujo, Takeshi, Yamazaki, Tomohiro, Kawaguchi, Tetsuya, Kurosaka, Satoshi, Takumi, Toru, Nakagawa, Shinichi, Hirose, Tetsuro

“…NEAT1_2 long noncoding RNA (lncRNA) is the molecular scaffold of paraspeckle nuclear bodies. Here, we report an improved RNA extraction method: extensive…”
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Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization by West, Jason A, Mito, Mari, Kurosaka, Satoshi, Takumi, Toru, Tanegashima, Chiharu, Chujo, Takeshi, Yanaka, Kaori, Kingston, Robert E, Hirose, Tetsuro, Bond, Charles, Fox, Archa, Nakagawa, Shinichi

“…Paraspeckles are nuclear bodies built on the long noncoding RNA Neat1, which regulates a variety of physiological processes including cancer progression and…”
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Change in serotonergic modulation contributes to the synaptic imbalance of neuronal circuit at the prefrontal cortex in the 15q11-13 duplication mouse model of autism by Saitow, Fumihito, Takumi, Toru, Suzuki, Hidenori

“…The prefrontal cortex (PFC) has been extensively studied in autism spectrum disorder (ASD) in an attempt to understand the deficits in executive and other…”
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GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time by Myung, Jihwan, Hong, Sungho, DeWoskin, Daniel, De Schutter, Erik, Forger, Daniel B., Takumi, Toru

“…The mammalian suprachiasmatic nucleus (SCN) forms not only the master circadian clock but also a seasonal clock. This neural network of ∼10,000 circadian…”
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Functional significance of rare neuroligin 1 variants found in autism by Nakanishi, Moe, Nomura, Jun, Ji, Xiao, Tamada, Kota, Arai, Takashi, Takahashi, Eiki, Bućan, Maja, Takumi, Toru

“…Genetic mutations contribute to the etiology of autism spectrum disorder (ASD), a common, heterogeneous neurodevelopmental disorder characterized by…”
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Glutamate and GABA in autism spectrum disorder—a translational magnetic resonance spectroscopy study in man and rodent models by Horder, Jamie, Petrinovic, Marija M., Mendez, Maria A., Bruns, Andreas, Takumi, Toru, Spooren, Will, Barker, Gareth J., Künnecke, Basil, Murphy, Declan G.

“…Autism spectrum disorder (ASD) is a pervasive neurodevelopmental syndrome with a high human and economic burden. The pathophysiology of ASD is largely unclear,…”
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UBE3A regulates the transcription of IRF, an antiviral immunity by Furumai, Ryohei, Tamada, Kota, Liu, Xiaoxi, Takumi, Toru

“…UBE3A is a gene responsible for the pathogenesis of Angelman syndrome (AS), a neurodevelopmental disorder characterized by symptoms such as intellectual…”
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End-to-end deep learning approach to mouse behavior classification from cortex-wide calcium imaging by Ajioka, Takehiro, Nakai, Nobuhiro, Yamashita, Okito, Takumi, Toru

“…Deep learning is a powerful tool for neural decoding, broadly applied to systems neuroscience and clinical studies. Interpretable and transparent models that…”
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Common Defects of Spine Dynamics and Circuit Function in Neurodevelopmental Disorders: A Systematic Review of Findings From in Vivo Optical Imaging of Mouse Models by Nakai, Nobuhiro, Takumi, Toru, Nakai, Junichi, Sato, Masaaki

“…optical imaging is a powerful tool for revealing brain structure and function at both the circuit and cellular levels. Here, we provide a systematic review of…”
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CHRONO integrates behavioral stress and epigenetic control of metabolism by Hatanaka, Fumiyuki, Takumi, Toru

“…Circadian rhythms are a critical part of the body's homeostatic mechanisms. These rhythms repeat with a cycle-length of approximately 24 h and are generated by…”
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Distinct roles for GABA across multiple timescales in mammalian circadian timekeeping by DeWoskin, Daniel, Jihwan Myung, Mino D. C. Belle, Hugh D. Piggins, Toru Takumi, Daniel B. Forger

“…Each day, over 50 billion synaptic signals, mediated by the neurotransmitter GABA, are sent between neurons in the central circadian pacemaker in the mammalian…”
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Mutations of optineurin in amyotrophic lateral sclerosis by Kawakami, Hideshi, Kawata, Akihiro, Maruyama, Hirofumi, Nodera, Hiroyuki, Komure, Osamu, Abe, Koji, Ito, Hidefumi, Hirano, Asao, Kinoshita, Yoshimi, Kato, Hidemasa, Hagiwara, Koichi, Watanabe, Yasuhito, Ogasawara, Kazumasa, Hirai, Takeshi, Takumi, Toru, Kato, Takeo, Morimoto, Nobutoshi, Morino, Hiroyuki, Kamada, Masaki, Kobatake, Keitaro, Suzuki, Naoki, Aoki, Masashi, Izumi, Yuishin, Matsuura, Shinya, Kaji, Ryuji, Suzuki, Hidenori, Kusaka, Hirofumi

“…Amyotrophic lateral sclerosis (ALS) has its onset in middle age and is a progressive disorder characterized by degeneration of motor neurons of the primary…”
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CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN by Ono, Daisuke, Honma, Ken-ichi, Schmal, Christoph, Takumi, Toru, Kawamoto, Takeshi, Fujimoto, Katsumi, Kato, Yukio, Honma, Sato

“…Clock genes Cry1 and Cry2 , inhibitory components of core molecular feedback loop, are regarded as critical molecules for the circadian rhythm generation in…”
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Comprehensive topographical map of the serotonergic fibers in the male mouse brain by Awasthi, Janak R., Tamada, Kota, Overton, Eric T. N., Takumi, Toru

“…It is well established that serotonergic fibers distribute throughout the brain. Abnormal densities or patterns of serotonergic fibers have been implicated in…”
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Morphological Classification of the Medial Frontal Cortex Based on Cadaver Dissections: A Guide for Interhemispheric Approach by IMADA, Yasutaka, TAKUMI, Toru, AOYAMA, Hirohiko, SADATOMO, Takashi, KURISU, Kaoru

“…The medial frontal cortex (MFC) is a part of the medial surface of the frontal lobe situated in the rostral portion of the corpus callosum (CC). In a surgical…”
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