Search Results - "Takuma Mihara"

Gamma power abnormalities in a Fmr1-targeted transgenic rat model of fragile X syndrome by Kozono, Naoki, Okamura, Ai, Honda, Sokichi, Matsumoto, Mitsuyuki, Mihara, Takuma

“…Fragile X syndrome (FXS) is characteristically displayed intellectual disability, hyperactivity, anxiety, and abnormal sensory processing…”
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Auditory Steady State Response; nature and utility as a translational science tool by Kozono, Naoki, Honda, Sokichi, Tada, Mariko, Kirihara, Kenji, Zhao, Zhilei, Jinde, Seiichiro, Uka, Takanori, Yamada, Hiroshi, Matsumoto, Mitsuyuki, Kasai, Kiyoto, Mihara, Takuma

“…The auditory steady-state response (ASSR) has been used to detect auditory processing deficits in patients with psychiatric disorders. However, the methodology…”
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Effects of (+)-bicuculline, a GABAa receptor antagonist, on auditory steady state response in free-moving rats by Yamazaki, Mayako, Honda, Sokichi, Tamaki, Keisuke, Irie, Megumi, Mihara, Takuma

“…Auditory steady-state responses (ASSRs) are states in which the electrical activity of the brain reacts steadily to repeated auditory stimuli. They are known…”
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Electrocorticographic effects of acute ketamine on non-human primate brains by Yan, Tianfang, Suzuki, Katsuyoshi, Kameda, Seiji, Maeda, Masashi, Mihara, Takuma, Hirata, Masayuki

“… Acute blockade of glutamate N-methyl-D-aspartate receptors by ketamine induces symptoms and electrophysiological changes similar to schizophrenia. Previous…”
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Enhancing Clinical Trials Through Synergistic Gamma Power Analysis by Honda, Sokichi, Matsumoto, Mitsuyuki, Tajinda, Katsunori, Mihara, Takuma

“…While the etiology of many neuropsychiatric disorders remains unknown, increasing evidence suggests that aberrant sensory processing plays a central role. For…”
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Chronic subdural electrocorticography in nonhuman primates by an implantable wireless device for brain-machine interfaces by Yan, Tianfang, Suzuki, Katsuyoshi, Kameda, Seiji, Maeda, Masashi, Mihara, Takuma, Hirata, Masayuki

“…Background Subdural electrocorticography (ECoG) signals have been proposed as a stable, good-quality source for brain-machine interfaces (BMIs), with a higher…”
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Computational identification of variables in neonatal vocalizations predictive for postpubertal social behaviors in a mouse model of 16p11.2 deletion by Nakamura, Mitsuteru, Ye, Kenny, e Silva, Mariel Barbachan, Yamauchi, Takahira, Hoeppner, Daniel J., Fayyazuddin, Amir, Kang, Gina, Yuda, Emi A., Nagashima, Masako, Enomoto, Shingo, Hiramoto, Takeshi, Sharp, Richard, Kaneko, Itaru, Tajinda, Katsunori, Adachi, Megumi, Mihara, Takuma, Tokuno, Shinichi, Geyer, Mark A., Broin, Pilib Ó, Matsumoto, Mitsuyuki, Hiroi, Noboru

“…Autism spectrum disorder (ASD) is often signaled by atypical cries during infancy. Copy number variants (CNVs) provide genetically identifiable cases of ASD,…”
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Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors by Chino, Ayaka, Seo, Ryushi, Amano, Yasushi, Namatame, Ichiji, Hamaguchi, Wataru, Honbou, Kazuya, Mihara, Takuma, Yamazaki, Mayako, Tomishima, Masaki, Masuda, Naoyuki

“…In this study, we report the identification of potent pyrimidoindazoles as phosphodiesterase10A (PDE10A) inhibitors by using the method of fragment-based drug…”
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Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques by Nakamura, Tomoya, Dinh, Trong Ha, Asai, Makoto, Nishimaru, Hiroshi, Matsumoto, Jumpei, Setogawa, Tsuyoshi, Ichijo, Hiroyuki, Honda, Sokichi, Yamada, Hiroshi, Mihara, Takuma, Nishijo, Hisao

“…Abstract Background Auditory steady-state responses (ASSRs) are periodic evoked responses to constant periodic auditory stimuli, such as click trains, and are…”
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Synthesis and in Vivo Evaluation of Novel Quinoline Derivatives as Phosphodiesterase 10A Inhibitors by Hamaguchi, Wataru, Masuda, Naoyuki, Samizu, Kiyohiro, Mihara, Takuma, Takama, Kaori, Watanabe, Toshihiro

“…A novel class of phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability in mouse liver microsomes were designed and synthesized starting…”
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Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in models of Parkinson's disease and cognition by Mihara, Takuma, Mihara, Kayoko, Yarimizu, Junko, Mitani, Yasuyuki, Matsuda, Ritsuko, Yamamoto, Hiroko, Aoki, Satoshi, Akahane, Atsushi, Iwashita, Akinori, Matsuoka, Nobuya

“…Central adenosine A(2A) receptor is a promising target for drugs to treat Parkinson's disease (PD), and the central blockade of adenosine A(1) receptor…”
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Addressing phototoxicity observed in a novel series of biaryl derivatives: Discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436 by Hamaguchi, Wataru, Masuda, Naoyuki, Miyamoto, Satoshi, Kikuchi, Shigetoshi, Narazaki, Fumie, Shiina, Yasuhiro, Seo, Ryushi, Amano, Yasushi, Mihara, Takuma, Moriguchi, Hiroyuki, Hattori, Kouji

“…[Display omitted] We synthesized several biaryl derivatives as PDE10A inhibitors to prevent phototoxicity of…”
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Non-invasive electroencephalographical (EEG) recording system in awake monkeys by Nakamura, Tomoya, Dinh, Trong Ha, Asai, Makoto, Nishimaru, Hiroshi, Matsumoto, Jumpei, Takamura, Yusaku, Hori, Etsuro, Honda, Sokichi, Yamada, Hiroshi, Mihara, Takuma, Matsumoto, Mitsuyuki, Nishijo, Hisao

“…Human clinical studies reported that several electroencephalographical (EEG) parameters can be used as biomarkers of psychiatric disorders. EEGs recorded from…”
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CS1C-1-3 The Mouse Socially-evoked Activity Task as a novel animal model of schizophrenia by Takuma Mihara, Steven.J.Siegel, Rosanna.M.Sobota, Robert Lin, Robert.E.Featherstone

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Pharmacological Characterization of FR194921, a New Potent, Selective, and Orally Active Antagonist for Central Adenosine A1 Receptors by Maemoto, Takuya, Tada, Miho, Mihara, Takuma, Ueyama, Noriko, Matsuoka, Hideaki, Harada, Katsuya, Yamaji, Takayuki, Shirakawa, Kiyoharu, Kuroda, Satoru, Akahane, Atsushi, Iwashita, Akinori, Matsuoka, Nobuya, Mutoh, Seitaro

“…Adenosine A1 receptors in the brain are believed to play an important role in brain functioning. We have discovered a novel adenosine A1 receptor antagonist,…”
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Brain Adenosine A2A Receptor Occupancy by a Novel A1/A2A Receptor Antagonist, ASP5854, in Rhesus Monkeys: Relationship to Anticataleptic Effect by Mihara, Takuma, Noda, Akihiro, Arai, Hiroshi, Mihara, Kayoko, Iwashita, Akinori, Murakami, Yoshihiro, Matsuya, Takahiro, Miyoshi, Sosuke, Nishimura, Shintaro, Matsuoka, Nobuya

“…The purpose of the present study was to measure adenosine A(2A) receptor (A(2A)R) occupancy in the brain by a novel adenosine A(1)/A(2A) antagonist,…”
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Effects of by Yamazaki, Mayako, Honda, Sokichi, Tamaki, Keisuke, Irie, Megumi, Mihara, Takuma

“…Auditory steady-state responses (ASSRs) are states in which the electrical activity of the brain reacts steadily to repeated auditory stimuli. They are known…”
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P3J-4-5 Two rat models for metabolic side effects of atypical antipsychotics： validation with olanzapine and ziprasidone by Miwako Shobo, Hiroshi Yamada, Takuma Mihara, Yuji Kondo, Megumi Irie, Katsuya Harada, Keni Ni, Nobuya Matsuoka

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A novel GABAB receptor positive allosteric modulator, ASP8062, exerts analgesic effects in a rat model of fibromyalgia by Murai, Nobuhito, Kondo, Yuji, Akuzawa, Shinobu, Mihara, Takuma, Shiraishi, Nobuyuki, Kakimoto, Shuichiro, Matsumoto, Mitsuyuki

“…The gamma-aminobutyric acid type B (GABAB) receptor agonist, the sodium salt of gamma-hydroxybutyrate (GHB), significantly improved pain, sleep disturbance and…”
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Oxytocin Reduces Amygdala Activity, Increases Social Interactions, and Reduces Anxiety-Like Behavior Irrespective of NMDAR Antagonism by Sobota, Rosanna, Mihara, Takuma, Forrest, Alexandra, Featherstone, Robert E, Siegel, Steven J

“…Standard dopamine therapies for schizophrenia are not efficacious for negative symptoms of the disease, including asociality. This reduced social behavior may…”
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