Search Results - "Takuma, Shinya"

Application of a quality by design approach to the cell culture process of monoclonal antibody production, resulting in the establishment of a design space by Nagashima, Hiroaki, Watari, Akiko, Shinoda, Yasuharu, Okamoto, Hiroshi, Takuma, Shinya

“…This case study describes the application of Quality by Design elements to the process of culturing Chinese hamster ovary cells in the production of a…”
Get more information

Optimization of chemically defined feed media for monoclonal antibody production in Chinese hamster ovary cells by Kishishita, Shohei, Katayama, Satoshi, Kodaira, Kunihiko, Takagi, Yoshinori, Matsuda, Hiroki, Okamoto, Hiroshi, Takuma, Shinya, Hirashima, Chikashi, Aoyagi, Hideki

“…Chinese hamster ovary (CHO) cells are the most commonly used mammalian host for large-scale commercial production of therapeutic monoclonal antibodies (mAbs)…”
Get full text

Effect of temperature shift on levels of acidic charge variants in IgG monoclonal antibodies in Chinese hamster ovary cell culture by Kishishita, Shohei, Nishikawa, Tomoko, Shinoda, Yasuharu, Nagashima, Hiroaki, Okamoto, Hiroshi, Takuma, Shinya, Aoyagi, Hideki

“…During the production of therapeutic monoclonal antibodies (mAbs), not only enhancement of mAb productivity but also control of quality attributes is critical…”
Get full text

Dependence on glucose limitation of the pCO2 influences on CHO cell growth, metabolism and IgG production by Takuma, Shinya, Hirashima, Chikashi, Piret, James M.

“…The culture levels of glucose and CO2 have been reported to independently have important influences on mammalian cell processes. In this work the combined…”
Get full text

Approaches to Quality Risk Management When Using Single-Use Systems in the Manufacture of Biologics by Ishii-Watabe, Akiko, Hirose, Akihiko, Katori, Noriko, Hashii, Norikata, Arai, Susumu, Awatsu, Hirotoshi, Eiza, Akira, Hara, Yoshiaki, Hattori, Hideshi, Inoue, Tomomi, Isono, Tetsuya, Iwakura, Masahiro, Kajihara, Daisuke, Kasahara, Nobuo, Matsuda, Hiroyuki, Murakami, Sei, Nakagawa, Taishiro, Okumura, Takehiro, Omasa, Takeshi, Takuma, Shinya, Terashima, Iyo, Tsukahara, Masayoshi, Tsutsui, Maiko, Yano, Takahiro, Kawasaki, Nana

“…ABSTRACT Biologics manufacturing technology has made great progress in the last decade. One of the most promising new technologies is the single-use system,…”
Get full text

Dependence on glucose limitation of the p CO 2 influences on CHO cell growth, metabolism and IgG production by Takuma, Shinya, Hirashima, Chikashi, Piret, James M.

“…Abstract The culture levels of glucose and CO 2 have been reported to independently have important influences on mammalian cell processes. In this work the…”
Get full text

Isolation of xylose reductase gene ofPichia stipitis and its expression inSaccharomyces cerevisiae by Takuma, Shinya, Nakashima, Noriyuki, Tantirungkij, Manee, Kinoshita, Shinichi, Okada, Hirosuke, Sew, TatsÜji, Yoshida, Toshiomi

Get full text

Isolation of xylose reductase gene of Pichia stipitis and its expression in Saccharomyces cerevisiae by Takuma, S. (Osaka University, Osaka, Japan), Nakashima, N, Tantirungkij, M, Kinosohita, S, Okada, H, Seki, T, Yoshida, T

“…A NADPH/NADH-dependent xylose reductase gene was isolated from the xylose-assimilating yeast, Pichia stipitis. DNA sequence analysis showed that the gene…”
Get full text