Search Results - "Taktak, Azzam"

The use of artificial neural networks in decision support in cancer: A systematic review by Lisboa, Paulo J., Taktak, Azzam F.G.

“…Artificial neural networks have featured in a wide range of medical journals, often with promising results. This paper reports on a systematic review that was…”
Get full text

Estimating prognosis for survival after treatment of choroidal melanoma by Damato, Bertil, Eleuteri, Antonio, Taktak, Azzam F.G., Coupland, Sarah E.

“…Choroidal melanoma is fatal in about 50% of patients. This is because of metastatic disease, which usually involves the liver. Kaplan–Meier survival curves…”
Get full text

Prognostication of metastatic death in uveal melanoma patients: A Markov multi-state model by Eleuteri, Antonio, Taktak, Azzam F.G., Coupland, Sarah E., Heimann, Heinrich, Kalirai, Helen, Damato, Bertil

“…Uveal melanoma is fatal in almost 50% of patients. We previously developed a prognostic model to predict all-cause mortality. The aim of this study was to…”
Get full text

Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors by Ireland, Lucy, Santos, Almudena, Ahmed, Muhammad S, Rainer, Carolyn, Nielsen, Sebastian R, Quaranta, Valeria, Weyer-Czernilofsky, Ulrike, Engle, Danielle D, Perez-Mancera, Pedro A, Coupland, Sarah E, Taktak, Azzam, Bogenrieder, Thomas, Tuveson, David A, Campbell, Fiona, Schmid, Michael C, Mielgo, Ainhoa

“…Tumor-associated macrophages (TAM) and myofibroblasts are key drivers in cancer that are associated with drug resistance in many cancers, including pancreatic…”
Get full text

Multiplex ligation-dependent probe amplification of conjunctival melanoma reveals common BRAF V600E gene mutation and gene copy number changes by Lake, Sarah L, Jmor, Fidan, Dopierala, Justyna, Taktak, Azzam F G, Coupland, Sarah E, Damato, Bertil E

“…To determine the occurrence of BRAF V600E gene mutations and copy number changes of all autosome arms and genes known to be frequently altered in tumorigenesis…”
Get full text

Sensitivity and Specificity of Different Prognostic Systems in Guiding Surveillance for Metastases in Uveal Melanoma by Robinson, Helena, Eleuteri, Antonio, Sacco, Joseph J, Hussain, Rumana, Heimann, Heinrich, Taktak, Azzam F G, Damato, Bertil, Thompson, Alexander J, Allen, Thomas, Kalirai, Helen, Coupland, Sarah E

“…Uveal melanoma (UM) metastasises in ~50% of patients, most frequently to the liver. Surveillance imaging can provide early detection of hepatic metastases;…”
Get full text

Effects of plaque brachytherapy and proton beam radiotherapy on prognostic testing: a comparison of uveal melanoma genotyped by microsatellite analysis by Thornton, Sophie, Coupland, Sarah E, Heimann, Heinrich, Hussain, Rumana, Groenewald, Carl, Kacperek, Andrzej, Damato, Bertil, Taktak, Azzam, Eleuteri, Antonio, Kalirai, Helen

“…Proton beam radiotherapy and plaque brachytherapy are commonly applied in primary uveal melanoma (UM); however, their effect on chromosome 3 classification of…”
Get more information

Cost-utility analysis of a decade of liver screening for metastases using the Liverpool Uveal Melanoma Prognosticator Online (LUMPO) by Eleuteri, Antonio, Rola, Alda Cunha, Kalirai, Helen, Hussain, Rumana, Sacco, Joseph, Damato, Bertil E., Heimann, Heinrich, Coupland, Sarah E., Taktak, Azzam F.G.

“…This paper outlines a method for cost-utility analysis of liver screening for metastases in patients with posterior uveal melanoma (UM). A semiparametric model…”
Get full text

Single Nucleotide Polymorphism Array Analysis of Uveal Melanomas Reveals That Amplification of CNKSR3 Is Correlated With Improved Patient Survival by Lake, Sarah L, Damato, Bertil E, Kalirai, Helen, Dodson, Andrew R, Taktak, Azzam F.G, Lloyd, Bryony H, Coupland, Sarah E

“…Metastatic death from uveal melanoma occurs almost exclusively with tumors showing monosomy of chromosome 3. However, approximately 5% of patients with a…”
Get full text

Genetic heterogeneity in uveal melanoma assessed by multiplex ligation-dependent probe amplification by Dopierala, Justyna, Damato, Bertil E, Lake, Sarah L, Taktak, Azzam F G, Coupland, Sarah E

“…To determine intratumor genetic heterogeneity in uveal melanoma (UM) by multiplex ligation-dependent probe amplification (MLPA) in formalin-fixed,…”
Get full text

Small High-Risk Uveal Melanomas Have a Lower Mortality Rate by Hussain, Rumana N., Coupland, Sarah E., Kalirai, Helen, Taktak, Azzam F. G., Eleuteri, Antonio, Damato, Bertil E., Groenewald, Carl, Heimann, Heinrich

“…Our aim was to determine whether size impacts on the difference in metastatic mortality of genetically high-risk (monosomy 3) uveal melanomas (UM). We…”
Get full text

A Retrospective Analysis of 10 Years of Liver Surveillance Undertaken in Uveal Melanoma Patients Treated at the Supraregional "Liverpool Ocular Oncology Centre", UK by Rola, Alda Cunha, Kalirai, Helen, Taktak, Azzam F G, Eleuteri, Antonio, Krishna, Yamini, Hussain, Rumana, Heimann, Heinrich, Coupland, Sarah E

“…To determine liver screening frequency and modality in UM patients following primary treatment, and the characteristics of detected metastases. A 10-year…”
Get full text

Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features, and clinical outcome by Kenawy, Nihal, Kalirai, Helen, Sacco, Joseph J., Lake, Sarah L., Heegaard, Steffen, Larsen, Ann‐Cathrine, Finger, Paul T., Milman, Tatyana, Chin, Kimberly, Mosci, Carlo, Lanza, Francesco, Moulin, Alexandre, Schmitt, Caroline A., Caujolle, Jean Pierre, Maschi, Célia, Marinkovic, Marina, Taktak, Azzam F., Heimann, Heinrich, Damato, Bertil E., Coupland, Sarah E.

“…Relatively little is known about the genetic aberrations of conjunctival melanomas (CoM) and their correlation with clinical and histomorphological features as…”
Get full text

Artificial Neural Networks Estimating Survival Probability after Treatment of Choroidal Melanoma by Damato, Bertil, MD, PhD, Eleuteri, Antonio, PhD, Fisher, Anthony C., PhD, Coupland, Sarah E., MBBS, PhD, Taktak, Azzam F.G., PhD, CSci

“…Purpose To describe neural networks predicting survival from choroidal melanoma (i.e., any uveal melanoma involving choroid) and to demonstrate the value of…”
Get full text

Whole-genome microarray detects deletions and loss of heterozygosity of chromosome 3 occurring exclusively in metastasizing uveal melanoma by Lake, Sarah L, Coupland, Sarah E, Taktak, Azzam F G, Damato, Bertil E

“…To detect deletions and loss of heterozygosity of chromosome 3 in a rare subset of fatal, disomy 3 uveal melanoma (UM), undetectable by fluorescence in situ…”
Get full text

Targeted Next-Generation Sequencing of 117 Routine Clinical Samples Provides Further Insights into the Molecular Landscape of Uveal Melanoma by Thornton, Sophie, Coupland, Sarah E, Olohan, Lisa, Sibbring, Julie S, Kenny, John G, Hertz-Fowler, Christiane, Liu, Xuan, Haldenby, Sam, Heimann, Heinrich, Hussain, Rumana, Kipling, Natalie, Taktak, Azzam, Kalirai, Helen

“…Uveal melanoma (UM) has well-characterised somatic copy number alterations (SCNA) in chromosomes 1, 3, 6 and 8, in addition to mutations in and , most being…”
Get full text

Cluster analysis of multiplex ligation-dependent probe amplification data in choroidal melanoma by Caines, Rhydian, Eleuteri, Antonio, Kalirai, Helen, Fisher, Anthony C, Heimann, Heinrich, Damato, Bertil E, Coupland, Sarah E, Taktak, Azzam F G

“…To determine underlying correlations in multiplex ligation-dependent probe amplification (MLPA) data and their significance regarding survival following…”
Get full text

Deferral of Treatment for Small Choroidal Melanoma and the Risk of Metastasis: An Investigation Using the Liverpool Uveal Melanoma Prognosticator Online (LUMPO) by Damato, Bertil, Eleuteri, Antonio, Taktak, Azzam, Hussain, Rumana, Fili, Maria, Stålhammar, Gustav, Heimann, Heinrich, Coupland, Sarah E

“…We estimated metastatic-death risk when the treatment of small choroidal melanomas is deferred until growth is observed. In 24 patients with choroidal melanoma…”
Get full text

Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma by Farquhar, Neil, Thornton, Sophie, Coupland, Sarah E, Coulson, Judy M, Sacco, Joseph J, Krishna, Yamini, Heimann, Heinrich, Taktak, Azzam, Cebulla, Colleen M, Abdel‐Rahman, Mohamed H, Kalirai, Helen

“…Uveal melanoma (UM) is a rare aggressive intraocular tumour with a propensity for liver metastases, occurring in ∼50% of patients. The tumour suppressor BAP1…”
Get full text

Mantle cell lymphoma treatment options for elderly/unfit patients: A systematic review by Alnassfan, Tahera, Cox‐Pridmore, Megan J., Taktak, Azzam, Till, Kathleen J

“…Mantle cell lymphoma (MCL) is a rare B‐cell non‐Hodgkin lymphoma (NHL) that is aggressive and incurable with existing therapies, presenting a significant unmet…”
Get full text