Search Results - "Takito, Jiro"

Heterogeneity and Actin Cytoskeleton in Osteoclast and Macrophage Multinucleation by Takito, Jiro, Nakamura, Masanori

“…Osteoclast signatures are determined by two transcriptional programs, the lineage-determining transcription pathway and the receptor activator of nuclear…”
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The Sealing Zone in Osteoclasts: A Self-Organized Structure on the Bone by Takito, Jiro, Inoue, Satoshi, Nakamura, Masanori

“…Osteoclasts form a specialized cell-matrix adhesion structure, known as the "sealing zone", during bone resorption. The sealing zone is a dynamic actin-rich…”
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Site-Specific Fracture Healing: Comparison between Diaphysis and Metaphysis in the Mouse Long Bone by Inoue, Satoshi, Takito, Jiro, Nakamura, Masanori

“…The process of fracture healing varies depending upon internal and external factors, such as the fracture site, mode of injury, and mechanical environment…”
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Symmetrical retrograde actin flow in the actin fusion structure is involved in osteoclast fusion by Takito, Jiro, Otsuka, Hirotada, Inoue, Satoshi, Kawashima, Tsubasa, Nakamura, Masanori

“…The aim of this study was to elucidate the role of the zipper-like structure (ZLS), a podosome-related structure that transiently appears at the cell contact…”
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Regulation of Osteoclast Multinucleation by the Actin Cytoskeleton Signaling Network by Takito, Jiro, Otsuka, Hirotada, Yanagisawa, Nobuaki, Arai, Hiroshi, Shiga, Masayasu, Inoue, Mitsuko, Nonaka, Naoko, Nakamura, Masanori

“…Although it is known that osteoclasts are multinucleated cells that are responsible for bone resorption, the mechanism by which their size is regulated is…”
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Extraction of nobiletin from Citrus Unshiu peels by supercritical fluid and its CRE-mediated transcriptional activity by Oba, Chisato, Ota, Masaki, Nomura, Koichiro, Fujiwara, Hironori, Takito, Jiro, Sato, Yoshiyuki, Ohizumi, Yasushi, Inomata, Hiroshi

“…Polymethoxyflavone (PMF) is one of bioactive compounds in Citrus Unshiu and included mainly in the peels rather than the fruits, seeds and leaves…”
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Decisive differences in the bone repair processes of the metaphysis and diaphysis in young mice by Inoue, Satoshi, Otsuka, Hirotada, Takito, Jiro, Nakamura, Masanori

“…Fractures are common traumatic injuries that mainly occur in the metaphyses of long bones such as the proximal humerus, distal radius, and proximal femur…”
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The transient appearance of zipper-like actin superstructures during the fusion of osteoclasts by Takito, Jiro, Nakamura, Masanori, Yoda, Masaki, Tohmonda, Takahide, Uchikawa, Shinichi, Horiuchi, Keisuke, Toyama, Yoshiaki, Chiba, Kazuhiro

“…Multinucleated osteoclasts are responsible for bone resorption. Hypermultinucleated osteoclasts are often observed in some bone-related diseases such as…”
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Dual functions of cell-autonomous and non–cell-autonomous ADAM10 activity in granulopoiesis by Yoda, Masaki, Kimura, Tokuhiro, Tohmonda, Takahide, Uchikawa, Shinichi, Koba, Takeshi, Takito, Jiro, Morioka, Hideo, Matsumoto, Morio, Link, Daniel C., Chiba, Kazuhiro, Okada, Yasunori, Toyama, Yoshiaki, Horiuchi, Keisuke

“…Previous studies have revealed various extrinsic stimuli and factors involved in the regulation of hematopoiesis. Among these, Notch-mediated signaling has…”
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PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts by Hikata, Tomohiro, Takaishi, Hironari, Takito, Jiro, Hakozaki, Akihiro, Furukawa, Mitsuru, Uchikawa, Shinichi, Kimura, Tokuhiro, Okada, Yasunori, Matsumoto, Masahito, Yoshimura, Akihiko, Nishimura, Riko, Reddy, Sakamuri V., Asahara, Hiroshi, Toyama, Yoshiaki

“…Cytokine signaling via various transcription factors regulates receptor activator of nuclear factor (NF)–κB ligand (RANKL)–mediated osteoclast differentiation…”
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Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells by Takito, Jiro, Kimura, Junko, Kajima, Koji, Uozumi, Nobuyuki, Watanabe, Makoto, Yokosuka, Akihito, Mimaki, Yoshihiro, Nakamura, Masanori, Ohizumi, Yasushi

“…Prevention and treatment of Alzheimer disease are urgent problems for elderly people in developed countries. We previously reported that nobiletin, a…”
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Precursors linked via the zipper-like structure or the filopodium during the secondary fusion of osteoclasts by Takito, Jiro, Nakamura, Masanori

“…We previously reported the transient appearance of an actin superstructure, called the zipper-like structure, during the primary fusion (fusion of mononuclear…”
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Unfolding of the myosin head by purealin in glycerol by Takito, Jiro, Kobayashi, Jun’ichi, Nakamura, Masanori, Ohizumi, Yasushi, Nonomura, Yoshiaki

“…Purealin is a small bioactive compound obtained from the marine sponge. The compound modulates various types of ATPase activity of myosin from skeletal muscle,…”
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Conversion of ES Cells to Columnar Epithelia by Hensin and to Squamous Epithelia by Laminin by Takito, Jiro, Al-Awqati, Qais

“…Single-layered epithelia are the first differentiated cell types to develop in the embryo, with columnar and squamous types appearing immediately after…”
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Accelerated Cartilage Resorption by Chondroclasts during Bone Fracture Healing in Osteoprotegerin-Deficient Mice by Ota, Norikazu, Takaishi, Hironari, Kosaki, Naoto, Takito, Jiro, Yoda, Masaki, Tohmonda, Takahide, Kimura, Tokuhiro, Okada, Yasunori, Yasuda, Hisataka, Kawaguchi, Hiroshi, Matsumoto, Morio, Chiba, Kazuhiro, Ikegami, Hiroyasu, Toyama, Yoshiaki

“…Receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG), a decoy receptor of RANKL, maintain bone mass by regulating the…”
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Dynamic expression of nectins in enamel organs of mouse incisors by Kawashima, Tsubasa, Takito, Jiro, Shimada, Yukie, Sato, Masashi, Inoue, Mitsuko, Miyazaki, Takashi, Miyata, Muneaki, Rikitake, Yoshiyuki, Takai, Yoshimi, Nakamura, Masanori

“…Nectins are immunoglobulin-like cell–cell adhesion molecules and are of four types, namely, nectin-1, nectin-2, nectin-3, and nectin-4. Cleft…”
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Induction of Terminal Differentiation in Epithelial Cells Requires Polymerization of Hensin by Galectin 3 by Hikita, Chinami, Vijayakumar, Soundarapandian, Takito, Jiro, Erdjument-Bromage, Hediyet, Tempst, Paul, Al-Awqati, Qais

“…During terminal differentiation, epithelia become columnar and develop specialized apical membrane structures (microvilli) and functions (regulated endocytosis…”
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Only Multimeric Hensin Located in the Extracellular Matrix Can Induce Apical Endocytosis and Reverse the Polarity of Intercalated Cells by Hikita, C, Takito, J, Vijayakumar, S, Al-Awqati, Q

“…When an intercalated epithelial cell line was seeded at low density and allowed to reach confluence, it located the anion exchanger band 3 in the apical…”
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The IRE1α-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix by Tohmonda, Takahide, Miyauchi, Yoshiteru, Ghosh, Rajarshi, Yoda, Masaki, Uchikawa, Shinichi, Takito, Jiro, Morioka, Hideo, Nakamura, Masaya, Iwawaki, Takao, Chiba, Kazuhiro, Toyama, Yoshiaki, Urano, Fumihiko, Horiuchi, Keisuke

“…During skeletal development, osteoblasts produce large amounts of extracellular matrix proteins and must therefore increase their secretory machinery to handle…”
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IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos by Furukawa, Mitsuru, Takaishi, Hironari, Takito, Jiro, Yoda, Masaki, Sakai, Sadaoki, Hikata, Tomohiro, Hakozaki, Akihiro, Uchikawa, Shinichi, Matsumoto, Morio, Chiba, Kazuhiro, Kimura, Tokuhiro, Okada, Yasunori, Matsuo, Koichi, Yoshida, Hiroki, Toyama, Yoshiaki

“…IL-27 was first discovered as a factor supporting initial Th1 immune responses. Subsequent studies revealed that this cytokine has pleiotropic effects,…”
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