Search Results - "Takesono, Aya"

Zinc oxide nanoparticles disrupt development and function of the olfactory sensory system impairing olfaction-mediated behaviour in zebrafish by Takesono, Aya, Dimitriadou, Sylvia, Clark, Nathaniel J, Handy, Richard D, Mourabit, Sulayman, Winter, Matthew J, Kudoh, Tetsuhiro, Tyler, Charles R

“…Zinc (Zn) is an essential metal present in numerous enzymes throughout the body, playing a vital role in animal and human health. However, the increasing use…”
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Estrogenic Mechanisms and Cardiac Responses Following Early Life Exposure to Bisphenol A (BPA) and Its Metabolite 4‑Methyl-2,4-bis(p‑hydroxyphenyl)pent-1-ene (MBP) in Zebrafish by Moreman, John, Takesono, Aya, Trznadel, Maciej, Winter, Matthew J, Perry, Alexis, Wood, Mark E, Rogers, Nicola J, Kudoh, Tetsuhiro, Tyler, Charles R

“…Environmental exposure to Bisphenol A (BPA) has been associated with a range of adverse health effects, including on the cardiovascular system in humans. Lack…”
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New insights into organ-specific oxidative stress mechanisms using a novel biosensor zebrafish by Mourabit, Sulayman, Fitzgerald, Jennifer A., Ellis, Robert P., Takesono, Aya, Porteus, Cosima S., Trznadel, Maciej, Metz, Jeremy, Winter, Matthew J., Kudoh, Tetsuhiro, Tyler, Charles R.

“…Reactive oxygen species (ROS) arise as a result from, and are essential in, numerous cellular processes. ROS, however, are highly reactive and if left…”
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Microtubules regulate migratory polarity through Rho/ROCK signaling in T cells by Takesono, Aya, Heasman, Sarah J, Wojciak-Stothard, Beata, Garg, Ritu, Ridley, Anne J

“…Migrating leukocytes normally have a polarized morphology with an actin-rich lamellipodium at the front and a uropod at the rear. Microtubules (MTs) are…”
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Application of Transgenic Zebrafish Models for Studying the Effects of Estrogenic Endocrine Disrupting Chemicals on Embryonic Brain Development by Takesono, Aya, Kudoh, Tetsuhiro, Tyler, Charles R

“…Endocrine disrupting chemicals (EDCs) are environmental pollutants that mimic hormones and/or disrupt their function. Estrogenic EDCs (eEDCs) interfere with…”
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Solute carrier family 3 member 2 (Slc3a2) controls yolk syncytial layer (YSL) formation by regulating microtubule networks in the zebrafish embryo by Takesono, Aya, Moger, Julian, Faroq, Sumera, Cartwright, Emma, Dawid, Igor B, Wilson, Stephen W, Kudoh, Tetsuhiro

“…The yolk syncytial layer (YSL) in the zebrafish embryo is a multinucleated syncytium essential for embryo development, but the molecular mechanisms underlying…”
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Early life exposure to ethinylestradiol enhances subsequent responses to environmental estrogens measured in a novel transgenic zebrafish by Green, Jon M., Lange, Anke, Scott, Aaron, Trznadel, Maciej, Wai, Htoo Aung, Takesono, Aya, Brown, A. Ross, Owen, Stewart F., Kudoh, Tetsuhiro, Tyler, Charles R.

“…Estrogen plays fundamental roles in a range of developmental processes and exposure to estrogen mimicking chemicals has been associated with various adverse…”
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Receptor-independent Activators of Heterotrimeric G-protein Signaling Pathways by Takesono, Aya, Cismowski, Mary J., Ribas, Catalina, Bernard, Michael, Chung, Peter, Hazard, Starr, Duzic, Emir, Lanier, Stephen M.

“…Heterotrimeric G-protein signaling systems are activated via cell surface receptors possessing the seven-membrane span motif. Several observations suggest the…”
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Improved generation of C57BL/6J mouse embryonic stem cells in a defined serum-free media by Cheng, Jun, Dutra, Amalia, Takesono, Aya, Garrett-Beal, Lisa, Schwartzberg, Pamela L.

“…C57BL/6 is a well‐characterized mouse strain that is used extensively for immunological and neurological research. The establishment of C57BL/6 ES cell lines…”
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Identification of a Truncated Form of the G-protein Regulator AGS3 in Heart That Lacks the Tetratricopeptide Repeat Domains by Pizzinat, Nathalie, Takesono, Aya, Lanier, Stephen M.

“…AGS3, a 650-amino acid protein encoded by an ∼4-kilobase (kb) mRNA enriched in rat brain, is a Gαi/Gαt-binding protein that competes with Gβγ for interaction…”
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Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling by CISMOWSKI, M. J, TAKESONO, A, CHIENLING MA, LIZANO, J. S, XIAOBING XIE, FUERNKRANZ, H, LANIER, S. M, DUZIC, E

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Pertussis Toxin-insensitive Activation of the Heterotrimeric G-proteins Gi/Go by the NG108-15 G-protein Activator by Ribas, Catalina, Takesono, Aya, Sato, Motohiko, Hildebrandt, John D., Lanier, Stephen M.

“…A ligand-independent activator of heterotrimeric brain G-protein was partially purified from detergent-solubilized extracts of the neuroblastoma-glioma cell…”
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Estrogens regulate early embryonic development of the olfactory sensory system via estrogen-responsive glia by Takesono, Aya, Schirrmacher, Paula, Scott, Aaron, Green, Jon M, Lee, Okhyun, Winter, Matthew J, Kudoh, Tetsuhiro, Tyler, Charles R

“…Estrogens are well-known to regulate development of sexual dimorphism of the brain; however, their role in embryonic brain development prior to…”
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Biosensor Zebrafish Provide New Insights into Potential Health Effects of Environmental Estrogens by Lee, Okhyun, Takesono, Aya, Tada, Masazumi, Tyler, Charles R., Kudoh, Tetsuhiro

“…Background: Environmental estrogens alter hormone signaling in the body that can induce reproductive abnormalities in both humans and wildlife. Available…”
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Activator of G-protein Signaling 1 Blocks GIRK Channel Activation by a G-protein-coupled Receptor by Takesono, Aya, Nowak, Mark W., Cismowski, Mary, Duzic, Emir, Lanier, Stephen M.

“…The Ras-related protein, activator ofG-protein signaling 1 (AGS1) or Dexras1, interacts with Gi/Goα and activates heterotrimeric G-protein signaling systems…”
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Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms by Winter, Matthew J., Pinion, Joseph, Tochwin, Anna, Takesono, Aya, Ball, Jonathan S., Grabowski, Piotr, Metz, Jeremy, Trznadel, Maciej, Tse, Karen, Redfern, Will S., Hetheridge, Malcolm J., Goodfellow, Marc, Randall, Andrew D., Tyler, Charles R.

“…Background and Purpose Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and…”
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Identification of modulators of mammalian G-protein signaling by functional screens in the yeast Saccharomyces cerevisiae by Cismowski, Mary J, Takesono, Aya, Ma, Chienling, Lanier, Stephen M, Duzic, Emir

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High-Content and Semi-Automated Quantification of Responses to Estrogenic Chemicals Using a Novel Translucent Transgenic Zebrafish by Green, Jon M, Metz, Jeremy, Lee, Okhyun, Trznadel, Maciej, Takesono, Aya, Brown, A. Ross, Owen, Stewart F, Kudoh, Tetsuhiro, Tyler, Charles R

“…Rapid embryogenesis, together with genetic similarities with mammals, and the desire to reduce mammalian testing, are major incentives for using the zebrafish…”
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T cell receptor–induced phosphoinositide-3-kinase p110δ activity is required for T cell localization to antigenic tissue in mice by Jarmin, Sarah J, David, Rachel, Ma, Liang, Chai, Jan-Guo, Dewchand, Hamlata, Takesono, Aya, Ridley, Anne J, Okkenhaug, Klaus, Marelli-Berg, Federica M

“…The establishment of T cell–mediated inflammation requires the migration of primed T lymphocytes from the blood stream and their retention in antigenic sites…”
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Kinase-Independent Functions for Itk in TCR-Induced Regulation of Vav and the Actin Cytoskeleton by Dombroski, Derek, Houghtling, Richard A, Labno, Christine M, Precht, Patricia, Takesono, Aya, Caplen, Natasha J, Billadeau, Daniel D, Wange, Ronald L, Burkhardt, Janis K, Schwartzberg, Pamela L

“…The Tec family kinase Itk is an important regulator of Ca(2+) mobilization and is required for in vivo responses to Th2-inducing agents. Recent data also…”
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