Search Results - "Takeoka, Kenneth"

Toxic Accumulation of LPS Pathway Intermediates Underlies the Requirement of LpxH for Growth of Acinetobacter baumannii ATCC 19606 by Richie, Daryl L, Takeoka, Kenneth T, Bojkovic, Jade, Metzger, 4th, Louis E, Rath, Christopher M, Sawyer, William S, Wei, Jun-Rong, Dean, Charles R

“…The lipid A moiety of lipopolysaccharide (LPS) is the main constituent of the outer leaflet of the Gram-negative bacterial outer membrane (OM) and is essential…”
Get full text

Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae by Dean, Charles R, Barkan, David T, Bermingham, Alun, Blais, Johanne, Casey, Fergal, Casarez, Anthony, Colvin, Richard, Fuller, John, Jones, Adriana K, Li, Cindy, Lopez, Sara, Metzger, 4th, Louis E, Mostafavi, Mina, Prathapam, Ramadevi, Rasper, Dita, Reck, Folkert, Ruzin, Alexey, Shaul, Jacob, Shen, Xiaoyu, Simmons, Robert L, Skewes-Cox, Peter, Takeoka, Kenneth T, Tamrakar, Pramila, Uehara, Tsuyoshi, Wei, Jun-Rong

“…The monobactam scaffold is attractive for the development of new agents to treat infections caused by drug-resistant Gram-negative bacteria because it is…”
Get full text

Determinants of Antibacterial Spectrum and Resistance Potential of the Elongation Factor G Inhibitor Argyrin B in Key Gram-Negative Pathogens by Jones, Adriana K, Woods, Angela L, Takeoka, Kenneth T, Shen, Xiaoyu, Wei, Jun-Rong, Caughlan, Ruth E, Dean, Charles R

“…Argyrins are natural products with antibacterial activity against Gram-negative pathogens, such as , , and We previously showed that argyrin B targets…”
Get full text

Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity by Skepper, Colin K, Moreau, Robert J, Appleton, Brent A, Benton, Bret M, Drumm, Joseph E, Feng, Brian Y, Geng, Mei, Hu, Cheng, Li, Cindy, Lingel, Andreas, Lu, Yipin, Mamo, Mulugeta, Mergo, Wosenu, Mostafavi, Mina, Rath, Christopher M, Steffek, Micah, Takeoka, Kenneth T, Uehara, Kyoko, Wang, Lisha, Wei, Jun-Rong, Xie, Lili, Xu, Wenjian, Zhang, Qiong, de Vicente, Javier

“…In the preceding manuscript [Moreau et al. 2018, 10.1021/acs.jmedchem.7b01691 ] we described a successful fragment-based lead discovery (FBLD) strategy for…”
Get full text

LpxK Is Essential for Growth of Acinetobacter baumannii ATCC 19606: Relationship to Toxic Accumulation of Lipid A Pathway Intermediates by Wei, Jun-Rong, Richie, Daryl L, Mostafavi, Mina, Metzger, 4th, Louis E, Rath, Christopher M, Sawyer, William S, Takeoka, Kenneth T, Dean, Charles R

“…ATCC 19606 can grow without lipid A, the major component of lipooligosaccharide. However, we previously reported that depletion of LpxH (the fourth enzyme in…”
Get full text

Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis by Mostafavi, Mina, Wang, Lisha, Xie, Lili, Takeoka, Kenneth T, Richie, Daryl L, Casey, Fergal, Ruzin, Alexey, Sawyer, William S, Rath, Christopher M, Wei, Jun-Rong, Dean, Charles R

“…Tight coordination of inner and outer membrane biosynthesis is very important in Gram-negative bacteria. Biosynthesis of the lipid A moiety of…”
Get full text

Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria by Moreau, Robert J, Skepper, Colin K, Appleton, Brent A, Blechschmidt, Anke, Balibar, Carl J, Benton, Bret M, Drumm, Joseph E, Feng, Brian Y, Geng, Mei, Li, Cindy, Lindvall, Mika K, Lingel, Andreas, Lu, Yipin, Mamo, Mulugeta, Mergo, Wosenu, Polyakov, Valery, Smith, Thomas M, Takeoka, Kenneth, Uehara, Kyoko, Wang, Lisha, Wei, Jun-Rong, Weiss, Andrew H, Xie, Lili, Xu, Wenjian, Zhang, Qiong, de Vicente, Javier

“…The discovery and development of new antibiotics capable of curing infections due to multidrug-resistant and pandrug-resistant Gram-negative bacteria are a…”
Get full text

Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis by Mostafavi, Mina, Wang, Lisha, Xie, Lili, Takeoka, Kenneth T., Richie, Daryl L., Casey, Fergal, Ruzin, Alexey, Sawyer, William S., Rath, Christopher M., Wei, Jun-Rong, Dean, Charles R.

“…Emergence of antibiotic resistance has prompted efforts to identify and optimize novel inhibitors of antibacterial targets such as LpxC. This enzyme catalyzes…”
Get full text

Optimization of CoaD Inhibitors against Gram-Negative Organisms through Targeted Metabolomics by Rath, Christopher M, Benton, Bret M, de Vicente, Javier, Drumm, Joseph E, Geng, Mei, Li, Cindy, Moreau, Robert J, Shen, Xiaoyu, Skepper, Colin K, Steffek, Micah, Takeoka, Kenneth, Wang, Lisha, Wei, Jun-Rong, Xu, Wenjian, Zhang, Qiong, Feng, Brian Y

“…Drug-resistant Gram-negative bacteria are of increasing concern worldwide. Novel antibiotics are needed, but their development is complicated by the…”
Get full text

Interplay of Klebsiella pneumoniae italic toggle="yes">fabZ /italic> and italic toggle="yes">lpxC /italic> Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis by Mina Mostafavi, Lisha Wang, Lili Xie, Kenneth T. Takeoka, Daryl L. Richie, Fergal Casey, Alexey Ruzin, William S. Sawyer, Christopher M. Rath, Jun-Rong Wei, Charles R. Dean

“…ABSTRACT Tight coordination of inner and outer membrane biosynthesis is very important in Gram-negative bacteria. Biosynthesis of the lipid A moiety of…”
Get full text