Search Results - "Takenouchi, Kazuya"

Development of 14-epi-19-Nortachysterol and Its Unprecedented Binding Configuration for the Human Vitamin D Receptor by Sawada, Daisuke, Tsukuda, Yuya, Saito, Hiroshi, Kakuda, Shinji, Takimoto-Kamimura, Midori, Ochiai, Eiji, Takenouchi, Kazuya, Kittaka, Atsushi

“…In the study of the synthesis of 14-epi-19-norprevitamin D3, we found 14-epi-19-nortachysterol derivatives through C6,7-cis/trans isomerization. We also…”
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Synthesis and Biological Activities of 1α,4α,25- and 1α,4β,25-Trihydroxyvitamin D3 and Their Metabolism by Human CYP24A1 and UDP-Glucuronosyltransferase by Sawada, Daisuke, Tsukuda, Yuya, Yasuda, Kaori, Sakaki, Toshiyuki, Saito, Hiroshi, Takagi, Ken-ichiro, Takenouchi, Kazuya, Chen, Tai C., Reddy, G. Satyanarayana, Kittaka, Atsushi

“…A previous report has demonstrated the existence of a C4-hydroxylated vitamin D2 metabolite in serum of rats treated with pharmacological doses of vitamin D2…”
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Synthesis and Biological Evaluation of 4-Substituted Vitamin D and 14-Epi-Previtamin D Analogs by Sawada, Daisuke, Tsukuda, Yuya, Saito, Hiroshi, Takagi, Ken-ichiro, Horie, Kyouhei, Ochiai, Eiji, Takenouchi, Kazuya, Kittaka, Atsushi

“…We synthesized the 4-hydroxy and 4-methoxy analogs of active vitamin D3 (1α,25(OH)2D3, 1) and its C14-epimer with the previtamin D3 form of…”
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Structure–activity relationship studies on vitamin D lactam derivatives as vitamin D receptor antagonist by Cho, Kaori, Uneuchi, Fumito, Kato-Nakamura, Yuko, Namekawa, Jun-ichi, Ishizuka, Seiichi, Takenouchi, Kazuya, Nagasawa, Kazuo

“…Structure–activity relationship studies on 1α,25-dihydroxyvitamin D 3-26,23-lactams (DLAMs), antagonists of vitamin D, were conducted, focusing on the…”
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Synthesis and Biological Activities of 14-epi-MART-10 and 14-epi-MART-11: Implications for Cancer and Osteoporosis Treatment by KITTAKA, Atsushi, HARA, Hideki, ISHIZUKA, Seiichi, HAYASHI, Keiko, IKUSHIRO, Shinichi, SAKAKI, Toshiyuki, SUGIURA, Takayuki, CHEN, Tai C, TAKANO, Masashi, SAWADA, Daisuke, ARAI, Midori A, TAKAGI, Kenichiro, CHIDA, Takayuki, HARADA, Yoshifumi, SAITO, Hiroshi, TAKENOUCHI, Kazuya

“…The 14-epimer of MART-10, namely 14-epi-MART-10 (14-epi-2α-(3-hydroxypropyl)-1α,25-dihydroxy-19-norvitamin D 3 ) and its 2-epimeric analog (14-epi-MART-11)…”
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Creative synthesis of novel vitamin D analogs for health and disease by Kittaka, Atsushi, Saito, Nozomi, Honzawa, Shinobu, Takenouchi, Kazuya, Ishizuka, Seiichi, Chen, Tai C., Peleg, Sara, Kato, Shigeaki, Arai, Midori A.

“…We report new analogs of 1α,25-dihydroxyvitamin D3 (1) in three categories. First, design and synthesis of ligands for a mutant vitamin D receptor…”
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Synthesis and Biological Activities of 1α,4α,25- and 1α,4β,25-Trihydroxyvitamin D3 and Their Metabolism by Human CYP24A1 and UDP-Glucuronosyltransferase by Daisuke Sawadaa, Yuya Tsukudaa, Kaori Yasudab, Toshiyuki Sakakib, Hiroshi Saitoc, Ken-ichiro Takagic, Kazuya Takenouchic, Tai C.Chend, G.Satyanarayana Reddye, f, Atsushi Kittakaa

“…A previous report has demonstrated the existence of a C4-hydroxylated vitamin D2 metabolite in serum of rats treated with pharmacological doses of vitamin D2…”
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Synthesis and structure-activity relationships of TEI-9647 derivatives as Vitamin D3 antagonists by TAKENOUCHI, Kazuya, SOGAWA, Ryo, MANABE, Kenji, SAITOH, Hiroshi, QINGZHI GAO, MIURA, Daishiro, ISHIZUKA, Seiichi

“…The Vitamin D(3) lactone analogues, (23S)- and (23R)-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactone (TEI-9647 and TEI-9648) are antagonists of the…”
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Synthesis and 2a-Modification of 24-Phenylvitamin D3 Lactones: Effects on VDR Antagonistic Activity by Kittaka, Atsushi, Saito, Nozomi, Matsunaga, Toshihiro, Saito, Hiroshi, Anzai, Miyuki, Takenouchi, Kazuya, Miura, Daishiro, Ishizuka, Seiichi, Takayama, Hiroaki

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Vitamin D and cancer by Yamana, Kei, Saito, Hiroshi, Takenouchi, Kazuya, Azuma, Yoshiaki, Ishizuka, Seiichi

“…Vitamin D is a steroid hormone which regulates calcium and bone homeostasis through intestine, bone, kidney and parathyroid. It has been reported that vitamin…”
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Synthesis and biological activities of vitamin D3 derivatives with cyanoalkyl side chain at C-2 position by Saitoh, Hiroshi, Watanabe, Hidekazu, Kakuda, Shinji, Takimoto-Kamimura, Midori, Takagi, Kenichiro, Takeuchi, Akiko, Takenouchi, Kazuya

“…•We synthesized vitamin D3 derivatives with cyanoalkyl side chain at C-2 position.•These novel derivatives showed strong transactivation activities.•Nitrogen…”
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Design and synthesis of 2α-(tetrazolylethyl)-1α,25-dihydroxyvitamin D3 as a high affinity ligand for vitamin D receptor by Matsuo, Miki, Hasegawa, Asami, Takano, Masashi, Saito, Hiroshi, Kakuda, Shinji, Takagi, Kenichiro, Ochiai, Eiji, Horie, Kyohei, Takimoto-Kamimura, Midori, Takenouchi, Kazuya, Sawada, Daisuke, Kittaka, Atsushi

“…•We synthesized 2α-heteroarylethyl active vitamin D3 for SAR study.•The 2α-[2-(tetrazol-2-yl)ethyl] group enhanced transactivation activity.•X-ray…”
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Synthesis of 14-epi-2α-hydroxypropoxy-1α,25-dihydroxy-19-nortachysterol and its hVDR binding by Sawada, Daisuke, Tsukuda, Yuya, Saito, Hiroshi, Takagi, Kenichiro, Kakuda, Shinji, Takimoto-Kamimura, Midori, Ochiai, Eiji, Takenouchi, Kazuya, Kittaka, Atsushi

“…▸ We synthesized a new stable 14-epi-19-nortachysterol derivative. ▸ We tested hVDR binding affinity of the 2α-substituted analog. ▸ The 2α-(3-hydroxypropoxy)…”
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Synthesis of C-2 substituted vitamin D derivatives having ringed side chains and their biological evaluation, especially biological effect on bone by modification at the C-2 position by Saitoh, Hiroshi, Chida, Takayuki, Takagi, Kenichiro, Horie, Kyohei, Sawai, Yoshiyuki, Nakamura, Yuko, Harada, Yoshifumi, Takenouchi, Kazuya, Kittaka, Atsushi

“…In order to obtain vitamin D derivatives, which have strong activity for enhancing bone growth, we designed vitamin D derivatives with various substitutions at…”
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Synthesis of novel C-2 substituted vitamin D derivatives having ringed side chains and their biological evaluation on bone by Saito, Hiroshi, Takagi, Kenichiro, Horie, Kyohei, Kakuda, Shinji, Takimoto-Kamimura, Midori, Ochiai, Eiji, Chida, Takayuki, Harada, Yoshifumi, Takenouchi, Kazuya, Kittaka, Atsushi

“…▸ We synthesized novel vitamin D3 derivatives with chiral cyclopentanone in the side chain. ▸ Novel derivatives showed strong transactivation activities in…”
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Synthesis of 2α-Heteroarylalkyl Active Vitamin D3 with Therapeutic Effect on Enhancing Bone Mineral Density in Vivo by Matsuo, Miki, Hasegawa, Asami, Takano, Masashi, Saito, Hiroshi, Kakuda, Shinji, Chida, Takayuki, Takagi, Ken-ichiro, Ochiai, Eiji, Horie, Kyohei, Harada, Yoshifumi, Takimoto-Kamimura, Midori, Takenouchi, Kazuya, Sawada, Daisuke, Kittaka, Atsushi

“…2α-Heteroarylethyl-1α,25-dihydroxyvitamin D3 analogues, which were designed to form a hydrogen bond between Arg274 of human vitamin D receptor (hVDR) and a…”
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Synthesis of 2α-Heteroarylalkyl Active Vitamin D 3 with Therapeutic Effect on Enhancing Bone Mineral Density in Vivo by Matsuo, Miki, Hasegawa, Asami, Takano, Masashi, Saito, Hiroshi, Kakuda, Shinji, Chida, Takayuki, Takagi, Ken-ichiro, Ochiai, Eiji, Horie, Kyohei, Harada, Yoshifumi, Takimoto-Kamimura, Midori, Takenouchi, Kazuya, Sawada, Daisuke, Kittaka, Atsushi

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Further Synthetic and Biological Studies on Vitamin D Hormone Antagonists Based on C24-Alkylation and C2α-Functionalization of 25-Dehydro-1α-hydroxyvitamin D 3 -26,23-lactones by Saito, Nozomi, Matsunaga, Toshihiro, Saito, Hiroshi, Anzai, Miyuki, Takenouchi, Kazuya, Miura, Daishiro, Namekawa, Jun-ichi, Ishizuka, Seiichi, Kittaka, Atsushi

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Synthesis of 2α- and 2β-substituted-14- epi-previtamin D 3 and their genomic activity by Sawada, Daisuke, Katayama, Tomoyuki, Tsukuda, Yuya, Saito, Nozomi, Saito, Hiroshi, Takagi, Ken-ichiro, Ochiai, Eiji, Ishizuka, Seiichi, Takenouchi, Kazuya, Kittaka, Atsushi

“…2α- and 2β-Substituted analogs of 14- epi-previtamin D 3 were synthesized and isolated after thermal isomerization of 14- epi-vitamin D 3 triene at 80 °C. The…”
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New C15-Substituted Active Vitamin D3 by Shindo, Kanako, Kumagai, Go, Takano, Masashi, Sawada, Daisuke, Saito, Nozomi, Saito, Hiroshi, Kakuda, Shinji, Takagi, Ken-ichiro, Ochiai, Eiji, Horie, Kyohei, Takimoto-Kamimura, Midori, Ishizuka, Seiichi, Takenouchi, Kazuya, Kittaka, Atsushi

“…C15-Substituted 1α,25-dihydroxyvitamin D3 analogs were synthesized for the first time to investigate the effects of the modified CD-ring on biological activity…”
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