Search Results - "Takegawa, Naoki"

Abstract 509: HER2 genomic amplification in circulating tumor DNA from patients with cetuximab-resistant colorectal cancer by TAKEGAWA, NAOKI

“…Abstract Background: Patients with metastatic colorectal cancer (mCRC) harboring wild-type KRAS benefit from epidermal growth factor receptor (EGFR)-targeted…”
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Traceability Management System Using Blockchain Technology and Cost Estimation in the Metrology Field by Takegawa, Naoki, Furuichi, Noriyuki

“…Metrological traceability is essential to ensure the reliability of calibration tests. Calibration certificates usually include information on only one…”
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Strategic coastal dike shape for enhanced tsunami overflow reduction by Takegawa, Naoki, Sawada, Yutaka, Furuichi, Noriyuki

“…Coastal dikes are an essential social infrastructure to mitigate tsunami damage. However, there are no clear guidelines on effective dike shapes for reducing…”
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B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity by Yonesaka, Kimio, Haratani, Koji, Takamura, Shiki, Sakai, Hitomi, Kato, Ryoji, Takegawa, Naoki, Takahama, Takayuki, Tanaka, Kaoru, Hayashi, Hidetoshi, Takeda, Masayuki, Kato, Sigeki, Maenishi, Osamu, Sakai, Kazuko, Chiba, Yasutaka, Okabe, Takafumi, Kudo, Keita, Hasegawa, Yoshikazu, Kaneda, Hiroyasu, Yamato, Michiko, Hirotani, Kenji, Miyazawa, Masaaki, Nishio, Kazuto, Nakagawa, Kazuhiko

“…Anti-programmed-death-1 (PD-1) immunotherapy improves survival in non-small cell lung cancer (NSCLC), but some cases are refractory to treatment, thereby…”
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HER2 as an Emerging Oncotarget for Colorectal Cancer Treatment After Failure of Anti-Epidermal Growth Factor Receptor Therapy by Takegawa, Naoki, Yonesaka, Kimio

“…Amplification of the HER2 gene is an indicator of poor prognosis for several kinds of malignancies such as breast and gastric cancer, and anti-HER2 targeting…”
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[fam‐] trastuzumab deruxtecan, antitumor activity is dependent on HER2 expression level rather than on HER2 amplification by Takegawa, Naoki, Tsurutani, Junji, Kawakami, Hisato, Yonesaka, Kimio, Kato, Ryoji, Haratani, Koji, Hayashi, Hidetoshi, Takeda, Masayuki, Nonagase, Yoshikane, Maenishi, Osamu, Nakagawa, Kazuhiko

“…Therapies targeted to human epidermal growth factor receptor 2 (HER2) have proven effective against tumors positive for HER2 amplification, but there is an…”
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An HER3-targeting antibody–drug conjugate incorporating a DNA topoisomerase I inhibitor U3-1402 conquers EGFR tyrosine kinase inhibitor-resistant NSCLC by Yonesaka, Kimio, Takegawa, Naoki, Watanabe, Satomi, Haratani, Koji, Kawakami, Hisato, Sakai, Kazuko, Chiba, Yasutaka, Maeda, Naoyuki, Kagari, Takashi, Hirotani, Kenji, Nishio, Kazuto, Nakagawa, Kazuhiko

“…EGFR tyrosine kinase inhibitors (TKIs) are standard therapy for EGFR-mutant non-small cell lung cancer (NSCLC); however, these tumours eventually acquire…”
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Verification of flow velocity measurements using micrometer-order thermometers by Takegawa, Naoki, Ishibashi, Masahiro, Iwai, Aya, Furuichi, Noriyuki, Morioka, Toshihiro

“…In flow velocity measurements, resolution, miniaturization, and accuracy of measuring devices are important issues because the measuring devices significantly…”
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Pretreatment Glasgow prognostic score as a predictor of outcomes in nivolumab-treated patients with advanced gastric cancer by Tokuyama, Nagahiro, Takegawa, Naoki, Nishikawa, Michiko, Sakai, Aya, Mimura, Takuya, Kushida, Saeko, Tsumura, Hidetaka, Yamamoto, Yoshinobu, Miki, Ikuya, Tsuda, Masahiro

“…In Japan, South Korea, and Taiwan, nivolumab might provide overall survival benefits for patients with advanced gastric cancer. However, it is effective only…”
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The impact of nutritional status in nivolumab-treated patients with advanced esophageal cancer by Takegawa, Naoki, Hirabayashi, Taku, Tanaka, Shunta, Nishikawa, Michiko, Tokuyama, Nagahiro, Mimura, Takuya, Kushida, Saeko, Tsumura, Hidetaka, Yamamoto, Yoshinobu, Miki, Ikuya, Tsuda, Masahiro

“…Although phase III trials have reported improved overall survival in patients with advanced esophageal squamous cell carcinoma following treatment with…”
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Morphine Versus Oxycodone for Cancer Pain Using a Catechol-O-methyltransferase Genotype Biomarker: A Multicenter, Randomized, Open-Label, Phase III Clinical Trial (RELIEF Study) by Matsuoka, Hiromichi, Tsurutani, Junji, Chiba, Yasutaka, Fujita, Yoshihiko, Sakai, Kiyohiro, Yoshida, Takeshi, Nakura, Miki, Sakamoto, Ryo, Makimura, Chihiro, Ohtake, Yoichi, Tanaka, Kaoru, Hayashi, Hidetoshi, Takeda, Masayuki, Okuno, Tatsuya, Takegawa, Naoki, Haratani, Koji, Koyama, Atsuko, Nishio, Kazuto, Nakagawa, Kazuhiko

“…Abstract Background We hypothesized that the high-dose opioid requirement in patients carrying the rs4680-GG variant in the COMT gene encoding…”
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Geogrid-based countermeasures against scour behind coastal dikes under tsunami overflow by Takegawa, Naoki, Sawada, Yutaka, Kawabata, Toshinori

“…Following the Great East Japan Earthquake, a massive tsunami caused serious damage to coastal dikes. Local scour at the ground behind these dikes reportedly…”
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A randomized controlled phase III trial comparing two chemotherapy regimen and chemoradiotherapy regimen as neoadjuvant treatment for locally advanced esophageal cancer, JCOG1109 NExT study by Kato, Ken, Ito, Yoshinori, Daiko, Hiroyuki, Ozawa, Soji, Ogata, Takashi, Hara, Hiroki, Kojima, Takashi, Abe, Tetsuya, Bamba, Takeo, Watanabe, Masaya, Kawakubo, Hirofumi, Shibuya, Yuichi, Tsubosa, Yasuhiro, Takegawa, Naoki, Kajiwara, Takeshi, Baba, Hideo, Ueno, Masaki, Machida, Ryunosuke, Nakamura, Kenichi, Kitagawa, Yuko

“…Abstract only 238 Background: Neoadjuvant treatment is the standard care for locally advanced esophageal squamous cell cancer (ESCC). JCOG1109 (UMIN000009482)…”
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Targeting of the HER2/HER3 signaling axis overcomes ligand‐mediated resistance to trastuzumab in HER2‐positive breast cancer by Watanabe, Satomi, Yonesaka, Kimio, Tanizaki, Junko, Nonagase, Yoshikane, Takegawa, Naoki, Haratani, Koji, Kawakami, Hisato, Hayashi, Hidetoshi, Takeda, Masayuki, Tsurutani, Junji, Nakagawa, Kazuhiko

“…HER2‐targeted therapy, especially the anti‐HER2 antibody trastuzumab, is standard for HER2‐positive breast cancer; however, its efficacy is limited in a…”
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Assessment of photodynamic therapy as a salvage treatment for local failure after chemoradiotherapy or radiotherapy for esophageal cancer in patients aged 80 years or older by Nishikawa, Michiko, Yamamoto, Yoshinobu, Kushida, Saeko, Hirabayashi, Taku, Tanaka, Syunta, Takegawa, Naoki, Mimura, Takuya, Tsumura, Hidetaka, Miki, Ikuya, Tsuda, Masahiro

“…Objectives Chemoradiotherapy (CRT) or radiotherapy (RT) alone is often the treatment of choice for elderly patients with esophageal cancer with the expectation…”
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T790M-Selective EGFR-TKI Combined with Dasatinib as an Optimal Strategy for Overcoming EGFR-TKI Resistance in T790M-Positive Non-Small Cell Lung Cancer by Watanabe, Satomi, Yoshida, Takeshi, Kawakami, Hisato, Takegawa, Naoki, Tanizaki, Junko, Hayashi, Hidetoshi, Takeda, Masayuki, Yonesaka, Kimio, Tsurutani, Junji, Nakagawa, Kazuhiko

“…T790M mutation-selective EGFR tyrosine kinase inhibitors (EGFR-TKI) have demonstrated clinical benefits in non-small cell lung cancer (NSCLC) patients…”
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Scour reduction in sand beds against vertical jets by applying sheet-like countermeasures by Takegawa, Naoki, Sawada, Yutaka, Kawabata, Toshinori

“…The scour observed at the landside ground behind coastal protection facilities, such as seawalls and coastal dikes, due to tsunami overflows is the main reason…”
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Type 1 diabetes mellitus affected by potential toxicity from long-term use of nivolumab by Motomura, Yuma, Urai, Shin, Hirota, Yushi, Takegawa, Naoki, Bando, Hironori, Yamamoto, Masaaki, Fukuoka, Hidenori, Tsuda, Masahiro, Ogawa, Wataru

“…We present a case of type 1 diabetes mellitus (T1DM) that developed in a 53-year-old man after long-term treatment with nivolumab. The patient underwent total…”
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Combined Analysis of Plasma Amphiregulin and Heregulin Predicts Response to Cetuximab in Metastatic Colorectal Cancer by Yonesaka, Kimio, Takegawa, Naoki, Satoh, Taroh, Ueda, Hiroto, Yoshida, Takeshi, Takeda, Masayuki, Shimizu, Toshio, Chiba, Yasutaka, Okamoto, Isamu, Nishio, Kazuto, Tamura, Takao, Nakagawa, Kazuhiko

“…Amphiregulin, a ligand of the epidermal growth factor receptor (EGFR), is associated with the efficacy of cetuximab, an antibody against EGFR, as treatment for…”
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Analytical methodology for calculating discharge coefficients of critical flow nozzles for high-pressure hydrogen by Takegawa, Naoki, Morioka, Toshihiro

“…Hydrogen is gaining attention as a clean energy source for the sustainable development of the global economy and mitigation of global warming. Flow rate…”
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