Search Results - "Takechi, T"

Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells by Takechi, T, Fujioka, A, Matsushima, E, Fukushima, M

“…The purpose of this study was to evaluate the use of 5-chloro-2,4-dihydroxypyridine (CDHP), a potent inhibitor of dihydropyrimidine dehydrogenase (DPD), to…”
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Thymidylate synthase (TS) and ribonucleotide reductase (RNR) may be involved in acquired resistance to 5-fluorouracil (5-FU) in human cancer xenografts in vivo by Fukushima, M, Fujioka, A, Uchida, J, Nakagawa, F, Takechi, T

“…A human tumour sub-line resistant to 5-fluorouracil (5-FU) was established by once a day and every 5, with at least 50 administrations of 5-FU to KM12C human…”
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Superior antitumour activity of S-1 in tumours with a high dihydropyrimidine dehydrogenase activity by Fujiwara, H., Terashima, M., Irinoda, T., Takagane, A., Abe, K., Nakaya, T., Yonezawa, H., Oyama, K., Takahashi, M., Saito, K., Takechi, T., Fukushima, M., Shirasaka, T.

“…To elucidate the mechanism of the enhanced antitumour activity of S-1 (1 M tegafur, 0.4 M 5-chloro-2, 4-dihydroxypyridine, and 1 M potassium oxonate) in terms…”
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Roles of thymidylate synthase and dihydropyrimidine dehydrogenase in tumor progression and sensitivity to 5-fluorouracil in human gastric cancer by Terashima, M, Irinoda, T, Fujiwara, H, Nakaya, T, Takagane, A, Abe, K, Yonezawa, H, Oyama, K, Inaba, T, Saito, K, Takechi, T, Fukushima, M

“…The role of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) enzyme activities in tumor progression and sensitivity to 5-fluorouracil (5-FU)…”
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Discrepancies between the gene expression, protein expression, and enzymatic activity of thymidylate synthase and dihydropyrimidine dehydrogenase in human gastrointestinal cancers and adjacent normal mucosa by Miyamoto, S, Ochiai, A, Boku, N, Ohtsu, A, Tahara, M, Yoshida, S, Okabe, H, Takechi, T, Fukushima, M

“…The relationships between gene expression, protein expression, and enzymatic activity of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD)…”
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Screening of Differentially Expressed Genes in 5‐Fluorouracil‐resistant Human Gastrointestinal Tumor Cells by Takechi, Teiji, Koizumi, Katsuhisa, Tsujimoto, Hiroaki, Fukushima, Masakazu

“…To identify genes differentially expressed in association with resistance to 5‐fluorouracil (5FU), an niRNA differential display (DD) analysis was used to…”
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Dihydropyrimidine dehydrogenase activity and mRNA expression in advanced gastric cancer analyzed in relation to effectiveness of preoperative 5-fluorouracil-based chemotherapy by Takabayashi, A, Iwata, S, Kawai, Y, Kanai, M, Taki, Y, Takechi, T, Fukushima, M

“…Dihydroxypyrimidine dehydrogenase (DPD) is an enzyme involved in degradation and inactivation of 5-fluorouracil (5-FU). The amount of its expression in a tumor…”
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Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro by Chu, Edward, Takechi, Teiji, Jones, Kristen L., Voeller, Donna M., Copur, Sitki M., Maley, Gladys F., Maley, Frank, Segal, Shoshana, Allegra, Carmen J.

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Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells by CHU, E, VOELLER, D. M, JONES, K. L, TAKECHI, T, MALEY, G. F, MALEY, F, SEGAL, S, ALLEGRA, C. J

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The effect of reducing reagents on binding of thymidylate synthase protein to thymidylate synthase messenger RNA by CHU, E, VOELLER, D. M, MORRISON, P. F, JONES, K. L, TAKECHI, T, MALEY, G. F, MALEY, F, ALLEGRA, C. J

“…Human thymidylate synthase (TS) protein specifically binds to its own TS mRNA and functions as a translational repressor. In the presence of reducing agents,…”
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An case report of a therapeutic vancomycin monitoring in an infant with shunt-related purulent meningitis by Takechi, T, Inai, N, Inoue, K, Kotani, H, Shiraishi, T, Ogura, H, Shinno, K

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Expression of recombinant human dihydropyrimidine dehydrogenase and its application to the preparation of anti-DPD antibodies for immunochemical detection by Okabe, H, Arakawa, K, Takechi, T, Fukushima, M

“…Dihydropyrimidine dehydrogenase (DPD) is a key enzyme in the catabolism of 5-fluorouracil (5-FU), and its expression in a tumor is thought to reduce the…”
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Liver tumor imaging by thallium-201 chloride with high resolution three-headed SPECT by Takechi, T

“…Thallium-201 chloride (Tl) is useful in tumor imaging. The purpose of this study was to evaluate its usefulness in liver tumor imaging with Tl, 99mTc…”
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Synthesis and fungicidal activity against Pyricularia oryzae of 6-(1,2,4-triazol-4-yl) chromone and -1-thiochromone derivatives by Gotoda, Satoshi, Takahashi, Nobuyoshi, Nakagawa, Hirofumi, Murakami, Mitsuyuki, Takechi, Tomoko, Komura, Tomozo, Uchida, Toshiro, Takagi, Yasushi

“…A series of novel 6‐(1,2,4‐triazol‐4‐yl) chromone and ‐1‐thiochromone (benzo[b]thiazin‐4‐one) derivatives was obtained by cyclisation via thiosemicarbazides…”
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Experimental postoperative adjuvant chemotherapy by UFT using primary tumor amputation model by Uchida, J, Sato, K, Okabe, H, Saito, H, Nakano, K, Fujioka, A, Takechi, T, Takeda, S, Unemi, N, Fukushima, M

“…We evaluated the postoperative adjuvant chemotherapy by UFT using the primary tumor amputation-pulmonary metastasis model. When Lewis lung carcinoma (LLC)…”
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Two Acyl-Coenzyme A Oxidases in Peroxisomes of the Yeast Candida tropicalis: Primary Structures Deduced from Genomic DNA Sequence by Okazaki, Koei, Takechi, Takanori, Kambara, Naoki, Fukui, Sakuzo, Kubota, Ichiro, Kamiryo, Tatsuyuki

“…We report the complete nucleotide sequence of two genes encoding major peroxisomal polypeptides (PXPs) of Candida tropicalis. One, POX4, encodes PXP-4, which…”
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Synthesis and Structure-Activity Relationships of Miticidal 4,5-Dihydropyrazole-5-thiones by Tada, Isao, Motoki, Minoru, Takahashi, Nobuyoshi, Miyata, Tetsuji, Takechi, Tomoko, Uchida, Toshiro, Takagi, Yasushi

“…A series of novel 4,5‐dihydropyrazole‐5‐thiones (DHPs) was synthesised by treating the corresponding dihydropyrazolones with ‘Lawesson’s reagent and evaluated…”
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Identification of new cystathionine mono-oxo acids, S-(3-oxo-3-carboxy-n-propyl) cysteine and S-(2-oxo-2-carboxyethyl) homocysteine, in the urine of a patient with cystathioninuria by Okada, T, Takechi, T, Wakiguchi, H, Kurashige, T, Sugahara, K, Kodama, H

“…Novel cystathionine mono-oxo acids, S-(3-oxo-3-carboxy-n-propyl) cysteine and S-(2-oxo-2-carboxyethyl) homocysteine, and cyclic amino acid, cystathionine…”
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Identification of N-acetyl-α-aminoadipic acid in the urine of a patient with α-aminoadipic and α-ketoadipic aciduria by TAKECHI, T, OKADA, T, WAKIGUCHI, H, MORITA, H, KURASHIGE, T, SUGAHARA, K, KODAMA, H

“…A 3.5-year-old Japanese boy with a mild speech disturbance excreted a large amount of alpha-aminoadipic acid into the urine. The amino acid analysis using an…”
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Characteristics of an air-fluidized-bed biofilm reactor system with a multi-media filter by Tsubone, T, Kanamori, S, Takechi, T, Takahashi, M

“…A pilot scale study was conducted using an Air-Fluidized-Bed Biofilm Reactor (AFBBR) system with a Multi Media Filter (MMF). Soluble BOD (S-BOD) concentration…”
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