Search Results - "Takechi, Kenshi"

Neurobehavioral Comorbidities in Pentylenetetrazol-kindled Mice and Role of the α4β2 Nicotinic Acetylcholine Receptor by Takechi, Kenshi

“…Patients with epilepsy are often affected by not only seizures but also a variety of cognitive and psychiatric comorbidities that further impair their quality…”
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Trends in Investigator-Initiated Clinical Studies at a University Hospital after Enforcement of the 2018 Clinical Trials Act in Japan by Sato, Yasutaka, Sakaguchi, Satoshi, Takechi, Kenshi, Chuma, Masayuki, Yagi, Kenta, Kane, Chikako, Goda, Mitsuhiro, Hamano, Hirofumi, Aoe, Yuki, Nokihara, Hiroshi, Kubo, Yoshiaki, Hashimoto, Ichiro, Yanagawa, Hiroaki

“…In April 2018, the Clinical Trials Act pertaining to investigator-initiated clinical trials was passed in Japan. The purpose of this study was to investigate…”
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Renin-Angiotensin-Aldosterone System Inhibitors Prevent the Onset of Oxaliplatin-Induced Peripheral Neuropathy: A Retrospective Multicenter Study and in Vitro Evaluation by Uchida, Mami, Ushio, Soichiro, Niimura, Takahiro, Takechi, Kenshi, Kawazoe, Hitoshi, Hidaka, Noriaki, Tanaka, Akihiro, Araki, Hiroaki, Zamami, Yoshito, Ishizawa, Keisuke, Kitamura, Yoshihisa, Sendou, Toshiaki, Kawasaki, Hiromu, Namba, Hiroyuki, Shibata, Kazuhiko, Tanaka, Mamoru, Takatori, Shingo

“…Oxaliplatin (OXA) is used in chemotherapy for various cancer types and is associated with acute and chronic neurotoxicity. However, a preventive strategy for…”
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Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway by Hamano, Hirofumi, Niimura, Takahiro, Horinouchi, Yuya, Zamami, Yoshito, Takechi, Kenshi, Goda, Mitsuhiro, Imanishi, Masaki, Chuma, Masayuki, Izawa-Ishizawa, Yuki, Miyamoto, Licht, Fukushima, Keijo, Fujino, Hiromichi, Tsuchiya, Koichiro, Ishizawa, Keisuke, Tamaki, Toshiaki, Ikeda, Yasumasa

“…•Proton pump inhibitors increase the risk of developing iron deficiency.•Omeprazole enhances the expression of hepcidin via aryl hydrocarbon receptor…”
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Deletion of H-ferritin in macrophages alleviates obesity and diabetes induced by high-fat diet in mice by Ikeda, Yasumasa, Watanabe, Hiroaki, Shiuchi, Tetsuya, Hamano, Hirofumi, Horinouchi, Yuya, Imanishi, Masaki, Goda, Mitsuhiro, Zamami, Yoshito, Takechi, Kenshi, Izawa-Ishizawa, Yuki, Miyamoto, Licht, Ishizawa, Keisuke, Aihara, Ken-ichi, Tsuchiya, Koichiro, Tamaki, Toshiaki

“…Aims/hypothesis Iron accumulation affects obesity and diabetes, both of which are ameliorated by iron reduction. Ferritin, an iron-storage protein, plays a…”
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Chronic Tear Deficiency Sensitizes Transient Receptor Potential Vanilloid 1-Mediated Responses in Corneal Sensory Nerves by Masuoka, Takayoshi, Yamashita, Yuka, Nakano, Katsuya, Takechi, Kenshi, Niimura, Takahiro, Tawa, Masashi, He, Qiang, Ishizawa, Keisuke, Ishibashi, Takaharu

“…Chronic tear deficiency enhances the excitability of corneal cold-sensitive nerves that detect ocular dryness, which can lead to discomfort in patients with…”
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Examination of the antiepileptic effects of valacyclovir using kindling mice― search for novel antiepileptic agents by drug repositioning using a large medical information database by Takahashi, Shimon, Takechi, Kenshi, Jozukuri, Natsumi, Niimura, Takahiro, Chuma, Masayuki, Goda, Mitsuhiro, Zamami, Yoshito, Izawa-Ishizawa, Yuki, Imanishi, Masaki, Horinouchi, Yuya, Ikeda, Yasumasa, Tsuchiya, Koichiro, Yanagawa, Hiroaki, Ishizawa, Keisuke

“…Despite the availability of more than 20 clinical antiepileptic drugs, approximately 30% of patients with epilepsy do not respond to antiepileptic drug…”
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Preventive Effects of Quercetin against the Onset of Atherosclerosis-Related Acute Aortic Syndromes in Mice by Kondo, Masateru, Izawa-Ishizawa, Yuki, Goda, Mitsuhiro, Hosooka, Mayuko, Kagimoto, Yuu, Saito, Naoko, Matsuoka, Rie, Zamami, Yoshito, Chuma, Masayuki, Yagi, Kenta, Takechi, Kenshi, Tsuneyama, Koichi, Ishizawa, Keisuke

“…Atherosclerosis-related acute aortic syndromes, such as aortic aneurysms or aortic dissection are life-threatening diseases. Since they develop suddenly and…”
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Identification of prophylactic drugs for oxaliplatin-induced peripheral neuropathy using big data by Zamami, Yoshito, Niimura, Takahiro, Kawashiri, Takehiro, Goda, Mitsuhiro, Naito, Yutaro, Fukushima, Keijo, Ushio, Soichiro, Aizawa, Fuka, Hamano, Hirofumi, Okada, Naoto, Yagi, Kenta, Miyata, Koji, Takechi, Kenshi, Chuma, Masayuki, Koyama, Toshihiro, Kobayashi, Daisuke, Shimazoe, Takao, Fujino, Hiromichi, Izawa-Ishizawa, Yuki, Ishizawa, Keisuke

“…Drug repositioning is a cost-effective method to identify novel disease indications for approved drugs; it requires a shorter developmental period than…”
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Effects of Palonosetron on Nausea and Vomiting Induced by Multiple-Day Chemotherapy: A Retrospective Study by Hamano, Hirofumi, Mitsuhashi, Chisato, Suzuki, Yoshiko, Zamami, Yoshito, Tsujinaka, Kaito, Okada, Naoto, Niimura, Takahiro, Hayama, Tatsuya, Imai, Toru, Ishida, Shunsuke, Sakamoto, Kumiko, Goda, Mitsuhiro, Takechi, Kenshi, Yagi, Kenta, Chuma, Masayuki, Horinouchi, Yuya, Shinomiya, Kazuaki, Ikeda, Yasumasa, Kirino, Yasushi, Nakamura, Toshimi, Yanagawa, Hiroaki, Hamada, Yasuhiro, Ishizawa, Keisuke

“…Patients who undergo multiple-day chemotherapy sessions experience hard-to-treat nausea and vomiting. Currently, there is no effective standard treatment for…”
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Perspectives of non-specialists on the potential to serve as ethics committee members by Kane, Chikako, Takechi, Kenshi, Chuma, Masayuki, Nokihara, Hiroshi, Takagai, Tomoko, Yanagawa, Hiroaki

“…Objective In Japan, under the new Clinical Trials Act pertaining to investigator-initiated clinical trials that came into effect on 1 April 2018, review boards…”
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Research Ethics Consultation in Nursing Studies by Kane, Chikako, Sakaguchi, Satoshi, Chuma, Masayuki, Yagi, Kenta, Takechi, Kenshi, Aoe, Yuki, Takagai, Tomoko, Yanagawa, Hiroaki

“…Despite the importance and acceptance of research ethics consultation as an entity in many medical research areas, little is known about its status in nursing…”
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Academic investigators’ interest in promoting specified clinical trials : Questionnaire survey before and after implementation of the Clinical Trial Act by Chuma, Masayuki, Takechi, Kenshi, Yagi, Kenta, Sakaguchi, Satoshi, Nokihara, Hiroshi, Kane, Chikako, Sato, Yasutaka, Niimura, Takahiro, Goda, Mitsuhiro, Zamami, Yoshito, Ishizawa, Keisuke, Yanagawa, Hiroaki

“…Background : Enforcement of the 2018 Clinical Trials Act (CTA) in Japan resulted in strict and complicated regulations surrounding intervention studies. Few…”
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Pharmacological approach for drug repositioning against cardiorenal diseases by Zamami, Yoshito, Imanishi, Masaki, Takechi, Kenshi, Ishizawa, Keisuke

“…New applications of approved clinically used drugs are being discovered. Drug repositioning is a proposed strategy for developing these drugs as therapeutic…”
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Non-steroidal anti-inflammatory drugs induce severe hematologic toxicities in lung cancer patients receiving pemetrexed plus carboplatin: A retrospective cohort study by Kawazoe, Hitoshi, Yano, Akiko, Ishida, Yuri, Takechi, Kenshi, Katayama, Hitoshi, Ito, Ryoji, Yakushijin, Yoshihiro, Moriguchi, Toshihide, Tanaka, Mamoru, Tanaka, Akihiro, Araki, Hiroaki

“…As the major toxicity induced by pemetrexed plus carboplatin is severe hematologic toxicities, the aim of this study was to determine the risk factors for…”
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Irinotecan-induced neutropenia is reduced by oral alkalization drugs: analysis using retrospective chart reviews and the spontaneous reporting database by Hamano, Hirofumi, Mitsui, Marin, Zamami, Yoshito, Takechi, Kenshi, Nimura, Takahiro, Okada, Naoto, Fukushima, Keijo, Imanishi, Masaki, Chuma, Masayuki, Horinouchi, Yuya, Izawa-Ishizawa, Yuki, Kirino, Yasushi, Nakamura, Toshimi, Teraoka, Kazuhiko, Ikeda, Yasumasa, Fujino, Hiromichi, Yanagawa, Hiroaki, Tamaki, Toshiaki, Ishizawa, Keisuke

“…Purpose SN-38, an active metabolite of irinotecan, is reabsorbed by the intestinal tract during excretion, causing diarrhoea and neutropenia. In addition, the…”
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Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery From 5-Fluorouracil–Induced Oral Mucositis by Watanabe, Shinichi, Suemaru, Katsuya, Takechi, Kenshi, Kaji, Hiroaki, Imai, Kimie, Araki, Hiroaki

“…Oral mucositis induced by chemotherapy or radiotherapy has an impact upon quality-of-life, is dose-limiting for chemotherapy, and causes considerable…”
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Psychiatric Patients with Antipsychotic Drug-Induced Hyperprolactinemia and Menstruation Disorders by Takechi, Kenshi, Yoshioka, Yurika, Kawazoe, Hitoshi, Tanaka, Mamoru, Takatori, Shingo, Kobayashi, Miwako, Matsuoka, Ichiro, Yanagawa, Hiroaki, Zamami, Yoshito, Imanishi, Masaki, Ishizawa, Keisuke, Tanaka, Akihiro, Araki, Hiroaki

“…Treatment with antipsychotic drugs has been associated with hyperprolactinemia. The same antipsychotic drugs have also been associated with side effects such…”
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Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-Induced Aortic Fibrosis by Kondo, Masateru, Imanishi, Masaki, Fukushima, Keijo, Ikuto, Raiki, Murai, Yoichi, Horinouchi, Yuya, Izawa-Ishizawa, Yuki, Goda, Mitsuhiro, Zamami, Yoshito, Takechi, Kenshi, Chuma, Masayuki, Ikeda, Yasumasa, Fujino, Hiromichi, Tsuchiya, Koichiro, Ishizawa, Keisuke

“…Abstract BACKGROUND Several reports from basic researches and clinical studies have suggested that xanthine oxidase (XO) inhibitors have suppressive effects on…”
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Concomitant Use of Multiple Nephrotoxins including Renal Hypoperfusion Medications Causes Vancomycin-Associated Nephrotoxicity: Combined Retrospective Analyses of Two Real-World Databases by Bando, Takashi, Chuma, Masayuki, Hamano, Hirofumi, Niimura, Takahiro, Okada, Naoto, Kondo, Masateru, Izumi, Yuki, Ishida, Shunsuke, Yoshioka, Toshihiko, Asada, Mizuho, Zamami, Yoshito, Takechi, Kenshi, Goda, Mitsuhiro, Miyata, Koji, Yagi, Kenta, Izawa-Ishizaka, Yuki, Azuma, Momoyo, Yanagawa, Hiroaki, Tasaki, Yoshikazu, Ishizawa, Keisuke

“…There is a growing concern about the relationship between vancomycin-associated nephrotoxicity (VAN) and concomitant use of nephrotoxins. We examined this…”
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