Search Results - "Takayuki Fukuda"

Selective fluorescence labeling of myristicin using Mizoroki-Heck coupling reaction. Application to nutmeg powder, oil, and human plasma samples by Fukuda, Takayuki, Iwata, Hikaru, Kishikawa, Naoya, El-Maghrabey, Mahmoud H., Ohyama, Kaname, Kawakami, Shigeru, Wada, Mitsuhiro, Kuroda, Naotaka

“…•First fluorescence labeling for the major toxic nutmeg constituent myristicin.•New labeling was based on Mizoroki-Heck coupling for myristicin terminal…”
Get full text

Clinical impact of the loss of chromosome 7q on outcomes of patients with myelodysplastic syndromes treated with allogeneic hematopoietic stem cell transplantation by Itonaga, Hidehiro, Ishiyama, Ken, Aoki, Kazunari, Aoki, Jun, Ishikawa, Takayuki, Ohashi, Kazuteru, Fukuda, Takayuki, Ozawa, Yukiyasu, Ota, Shuichi, Uchida, Naoyuki, Eto, Tetsuya, Iwato, Koji, Ohno, Yuju, Takanashi, Minoko, Ichinohe, Tatsuo, Atsuta, Yoshiko, Miyazaki, Yasushi

“…We conducted a nationwide retrospective study to evaluate the prognostic influence of +1, der(1;7)(q10;p10) [hereafter der(1;7)] and −7/del(7q) after…”
Get full text

Follow-up genotoxicity assessment of Ames-positive/equivocal chemicals using the improved thymidine kinase gene mutation assay in DNA repair-deficient human TK6 cells by Sassa, Akira, Fukuda, Takayuki, Ukai, Akiko, Nakamura, Maki, Sato, Ryosuke, Fujiwara, Sho, Hirota, Kouji, Takeda, Shunichi, Sugiyama, Kei-ichi, Honma, Masamitsu, Yasui, Manabu

“…Abstract Genotoxicity testing plays an important role in the safety assessment of pharmaceuticals, pesticides and chemical substances. Among the guidelines for…”
Get full text

Detection of hepatocarcinogens by combination of liver micronucleus assay and histopathological examination in 2-week or 4-week repeated dose studies by Hamada, Shuichi, Shigano, Miyuki, Wako, Yumi, Kawasako, Kazufumi, Satomoto, Kensuke, Mitsumoto, Tatsuya, Fukuda, Takayuki, Ohyama, Wakako, Morita, Takeshi, Hayashi, Makoto

“…Currently, revisions to the ICH S1 guidance on rodent carcinogenicity testing are being proposed. Application of this approach would reduce the use of animals…”
Get full text

Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions by Fukuda, Takayuki, Takayama, Kazuo, Hirata, Mitsuhi, Liu, Yu-Jung, Yanagihara, Kana, Suga, Mika, Mizuguchi, Hiroyuki, Furue, Miho K.

“…Limited growth potential, narrow ranges of sources, and difference in variability and functions from batch to batch of primary hepatocytes cause a problem for…”
Get full text

The PIGRET assay, a method for measuring Pig-a gene mutation in reticulocytes, is reliable as a short-term in vivo genotoxicity test: Summary of the MMS/JEMS-collaborative study across 16 laboratories using 24 chemicals by Kimoto, Takafumi, Horibata, Katsuyoshi, Miura, Daishiro, Chikura, Satsuki, Okada, Yuki, Ukai, Akiko, Itoh, Satoru, Nakayama, Shiho, Sanada, Hisakazu, Koyama, Naomi, Muto, Shigeharu, Uno, Yoshifumi, Yamamoto, Mika, Suzuki, Yuta, Fukuda, Takayuki, Goto, Ken, Wada, Kunio, Kyoya, Takahiro, Shigano, Miyuki, Takasawa, Hironao, Hamada, Shuichi, Adachi, Hideki, Uematsu, Yasuaki, Tsutsumi, Eri, Hori, Hisako, Kikuzuki, Ryuta, Ogiwara, Yosuke, Yoshida, Ikuma, Maeda, Akihisa, Narumi, Kazunori, Fujiishi, Yohei, Morita, Takeshi, Yamada, Masami, Honma, Masamitsu

“…•The PIGRET assay offers strong potential as a short-term in vivo genotoxicity test.•Technical transferability of both the PIGRET and RBC Pig-a assay was…”
Get full text

Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells by Yanagihara, Kana, Liu, Yujung, Kanie, Kei, Takayama, Kazuo, Kokunugi, Minako, Hirata, Mitsuhi, Fukuda, Takayuki, Suga, Mika, Nikawa, Hiroki, Mizuguchi, Hiroyuki, Kato, Ryuji, Furue, Miho K

“…Functional hepatocytes derived from human pluripotent stem cells (hPSCs) have potential as tools for predicting drug-induced hepatotoxicity in the early phases…”
Get more information

Strength of plasma coating and effect of a plasma coating on hydrogen entry by Nishiguchi, Hiroshi, Ohshima, Tamiko, Kawasaki, Hiroharu, Fukuda, Takayuki

“…The strength of a plasma coating and the effect of the plasma coating on hydrogen entry were investigated to establish a method that provides a base material…”
Get full text

Comparative study of cytotoxic effects induced by environmental genotoxins using XPC- and CSB-deficient human lymphoblastoid TK6 cells by Sassa, Akira, Fukuda, Takayuki, Ukai, Akiko, Nakamura, Maki, Takabe, Michihito, Takamura-Enya, Takeji, Honma, Masamitsu, Yasui, Manabu

“…The human genome is constantly exposed to numerous environmental genotoxicants. To prevent the detrimental consequences induced by the expansion of damaged…”
Get full text

Effects of large amounts of hydrogen on the fatigue crack growth behavior of torsional prestrained carbon steel by Matsuda, Yuta, Nishiguchi, Hiroshi, Fukuda, Takayuki

“…The effects of large amounts of hydrogen on the fatigue crack growth properties of torsional prestrained ferritic–pearlitic low-carbon steel were investigated…”
Get full text

Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS by Yasui, Manabu, Fukuda, Takayuki, Ukai, Akiko, Maniwa, Jiro, Imamura, Tadashi, Hashizume, Tsuneo, Yamamoto, Haruna, Shibuya, Kaori, Narumi, Kazunori, Fujiishi, Yohei, Okada, Emiko, Fujishima, Saori, Yamamoto, Mika, Otani, Naoko, Nakamura, Maki, Nishimura, Ryoichi, Ueda, Maya, Mishima, Masayuki, Matsuzaki, Kaori, Takeiri, Akira, Tanaka, Kenji, Okada, Yuki, Nakagawa, Munehiro, Hamada, Shuichi, Kajikawa, Akihiko, Honda, Hiroshi, Adachi, Jun, Misaki, Kentaro, Ogawa, Kumiko, Honma, Masamitsu

“…Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species differences in metabolism,…”
Get full text

Characterization of bio-nanocapsule as a transfer vector targeting human hepatocyte carcinoma by disulfide linkage modification by Nagaoka, Tadahiro, Fukuda, Takayuki, Yoshida, Shinnosuke, Nishimura, Hirohito, Yu, Dongwei, Kuroda, Shun'ichi, Tanizawa, Katsuyuki, Kondo, Akihiko, Ueda, Masakazu, Yamada, Hidenori, Tada, Hiroko, Seno, Masaharu

“…The bio-nanocapsules (BNCs) composed of the recombinant envelope L-protein of hepatitis B virus constitute efficient delivery vectors specifically targeting…”
Get full text

Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests : a collaborative study by MMS / JEMS by Manabu Yasui, Takayuki Fukuda, Akiko Ukai, Jiro Maniwa, Tadashi Imamura, Tsuneo Hashizume, Haruna Yamamoto, Kaori Shibuya, Kazunori Narumi, Yohei Fujiishi, Emiko Okada, Saori Fujishima, Mika Yamamoto, Naoko Otani, Maki Nakamura, Ryoichi Nishimura, Maya Ueda, Masayuki Mishima, Kaori Matsuzaki, Akira Takeiri, Kenji Tanaka, Yuki Okada, Munehiro Nakagawa, Shuichi Hamada, Akihiko Kajikawa, Hiroshi Honda, Jun Adachi, Kentaro Misaki, Kumiko Ogawa, Masamitsu Honma

“…[Abstract][Background:] Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species…”
Get full text

Eosinophil cationic protein enhances cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells by stimulating the FGF receptor signaling pathway by Jin, Guoliang, Mizutani, Akifumi, Fukuda, Takayuki, Chen, Ling, Nakanishi, Keisuke, Yan, Ting, Kudoh, Takayuki, Hirohata, Satoshi, Kasai, Tomonari, Murakami, Hiroshi, Salomon, David S., Seno, Masaharu

“…We investigated the functional role of eosinophil cationic protein (ECP) in regulating cardiomyogenesis using mouse P19CL6 embryonic carcinoma cells. ECP was…”
Get full text

The specific delivery of proteins to human liver cells by engineered bio‐nanocapsules by Yu, Dongwei, Amano, Chie, Fukuda, Takayuki, Yamada, Tadanori, Kuroda, Shun'ichi, Tanizawa, Katsuyuki, Kondo, Akihiko, Ueda, Masakazu, Yamada, Hidenori, Tada, Hiroko, Seno, Masaharu

“…A bio‐nanocapsule (BNC), composed of the surface antigen (sAg) of the hepatitis B virus, is an efficient nanomachine with which to accomplish the…”
Get full text

Methyl-CpG binding protein 2 gene ( MECP2) variations in Japanese patients with Rett syndrome: pathological mutations and polymorphisms by Fukuda, Takayuki, Yamashita, Yushiro, Nagamitsu, Shinichiro, Miyamoto, Kenichi, Jin, Jing-Ji, Ohmori, Iori, Ohtsuka, Yoko, Kuwajima, Katsuko, Endo, Shoichi, Iwai, Tsuyako, Yamagata, Hidehisa, Tabara, Yasuharu, Miki, Tetsuro, Matsuishi, Toyojiro, Kondo, Ikuko

“…A total of 45 different mutations of methyl-CpG-binding protein 2 gene ( MECP2) were identified in 145 of 219 Japanese patients with typical or atypical Rett…”
Get full text

Human eosinophil cationic protein enhances stress fiber formation in Balb/c 3T3 fibroblasts and differentiation of rat neonatal cardiomyocytes by Fukuda, Takayuki, Iwata, Miki, Kitazoe, Midori, Maeda, Takashi, Salomon, David, Hirohata, Satoshi, Tanizawa, Katsuyuki, Kuroda, Shun'ichi, Seno, Masaharu

“…We found that eosinophil cationic protein (ECP) stimulated the growth of mouse Balb/c 3T3 fibroblasts. ECP-treated 3T3 cells were more flattened and exhibited…”
Get full text

Identification of cell surface marker candidates on SV-T2 cells using DNA microarray on DLC-coated glass by Tuoya, Hirayama, Koichi, Nagaoka, Tadahiro, Yu, Dongwei, Fukuda, Takayuki, Tada, Hiroko, Yamada, Hidenori, Seno, Masaharu

“…We analyzed gene expression profiles of normal mouse fibroblast BALB/c 3T3 cells and its SV40 transformant SV-T2 cells using our originally developed cell…”
Get full text

Engineered bio‐nanocapsules, the selective vector for drug delivery system by Yu, Dongwei, Fukuda, Takayuki, Kuroda, Shun'ichi, Tanizawa, Katsuyuki, Kondo, Akihiko, Ueda, Masakazu, Yamada, Tadanori, Tada, Hiroko, Seno, Masaharu

“…The bio‐nanocapsule (BNC) is our concept of artificial hollow nanoparticles that have been designed and produced through biotechnological procedures. We…”
Get full text

4-Iodobenzonitrile as a fluorogenic derivatization reagent for chromatographic analysis of L-p-boronophenylalanine in whole blood samples using Suzuki coupling reaction by Fukuda, Takayuki, Kishikawa, Naoya, El-Maghrabey, Mahmoud, Nakamura, Saori, Ohba, Yoshihito, Kawakami, Shigeru, Wada, Mitsuhiro, Kuroda, Naotaka

“…L-p-Boronophehylalanine (BPA) is used in boron neutron capture therapy (BNCT), which is a novel selective cancer radiotherapy technique. It is important to…”
Get full text