Search Results - "Takayanagi, Shuko"
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Generation of heterozygous PKD1 mutant pigs exhibiting early-onset renal cyst formation
Published in Laboratory investigation (01-05-2022)“…Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease, manifesting as the progressive development of fluid-filled…”
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Anephrogenic phenotype induced by SALL1 gene knockout in pigs
Published in Scientific reports (29-05-2019)“…To combat organ shortage in transplantation medicine, a novel strategy has been proposed to generate human organs from exogenous pluripotent stem cells…”
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Generation of interleukin-2 receptor gamma gene knockout pigs from somatic cells genetically modified by zinc finger nuclease-encoding mRNA
Published in PloS one (09-10-2013)“…Zinc finger nuclease (ZFN) is a powerful tool for genome editing. ZFN-encoding plasmid DNA expression systems have been recently employed for the generation of…”
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Phenotypic features of dystrophin gene knockout pigs harboring a human artificial chromosome containing the entire dystrophin gene
Published in Molecular therapy. Nucleic acids (12-09-2023)“…Mammalian artificial chromosomes have enabled the introduction of extremely large amounts of genetic information into animal cells in an autonomously…”
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Phenotypic features of genetically modified DMD-XKOXWT pigs
Published in Regenerative therapy (01-12-2023)“…Duchenne muscular dystrophy (DMD) is a hereditary neuromuscular disorder caused by mutation in the dystrophin gene (DMD) on the X chromosome. Female DMD…”
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Production of transgenic cloned pigs expressing the far-red fluorescent protein monomeric Plum
Published in Journal of Reproduction and Development (2015)“…Monomeric Plum (Plum), a far-red fluorescent protein with photostability and photopermeability, is potentially suitable for in vivo imaging and detection of…”
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A transgenic-cloned pig model expressing non-fluorescent modified Plum
Published in Journal of Reproduction and Development (2016)“…Genetically modified pigs that express fluorescent proteins such as green and red fluorescent proteins have become indispensable biomedical research tools in…”
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Generation of α1,3-galactosyltransferase and cytidine monophospho-N-acetylneuraminic acid hydroxylase gene double-knockout pigs
Published in Journal of Reproduction and Development (2015)“…Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) are new tools for producing gene knockout (KO) animals. The current…”
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Knockout of exogenous EGFP gene in porcine somatic cells using zinc-finger nucleases
Published in Biochemical and biophysical research communications (05-11-2010)“…► EGFP gene integrated in porcine somatic cells could be knocked out using the ZFN-KO system. ► ZFNs induced targeted mutations in porcine primary cultured…”
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Correction: Generation of Interleukin-2 Receptor Gamma Gene Knockout Pigs from Somatic Cells Genetically Modified by Zinc Finger Nuclease-Encoding mRNA
Published in PloS one (07-01-2014)Get full text
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High Frequency of BRAF super(V600E) Mutation in Acquired Nevi and Small Congenital Nevi, but Low Frequency of Mutation in Medium-Sized Congenital Nevi
Published in Journal of investigative dermatology (01-09-2006)“…To investigate whether the frequency of the BRAF super(V600E) (V-raf murine sarcoma virus oncogene homolog B1) mutation in melanocytic nevi is associated with…”
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Correction: Generation of Interleukin-2 Receptor Gamma Gene Knockout Pigs from Somatic Cells Genetically Modified by Zinc Finger Nuclease-Encoding mRNA
Published in PloS one (01-01-2014)Get full text
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High Frequency of BRAFV600E Mutation in Acquired Nevi and Small Congenital Nevi, but Low Frequency of Mutation in Medium-Sized Congenital Nevi
Published in Journal of investigative dermatology (01-09-2006)“…To investigate whether the frequency of the BRAFV600E (V-raf murine sarcoma virus oncogene homolog B1) mutation in melanocytic nevi is associated with sun…”
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