Search Results - "Takayanagi, Shin"

A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression by Kikushige, Yoshikane, Miyamoto, Toshihiro, Yuda, Junichiro, Jabbarzadeh-Tabrizi, Siamak, Shima, Takahiro, Takayanagi, Shin-ichiro, Niiro, Hiroaki, Yurino, Ayano, Miyawaki, Kohta, Takenaka, Katsuto, Iwasaki, Hiromi, Akashi, Koichi

“…Signaling mechanisms underlying self-renewal of leukemic stem cells (LSCs) are poorly understood, and identifying pathways specifically active in LSCs could…”
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TIM-3 Is a Promising Target to Selectively Kill Acute Myeloid Leukemia Stem Cells by Kikushige, Yoshikane, Shima, Takahiro, Takayanagi, Shin-ichiro, Urata, Shingo, Miyamoto, Toshihiro, Iwasaki, Hiromi, Takenaka, Katsuto, Teshima, Takanori, Tanaka, Toshiyuki, Inagaki, Yoshimasa, Akashi, Koichi

“…Acute myeloid leukemia (AML) originates from self-renewing leukemic stem cells (LSCs), an ultimate therapeutic target for AML. Here we identified T cell…”
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Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal by Xie, Stephanie Z., Garcia-Prat, Laura, Voisin, Veronique, Ferrari, Robin, Gan, Olga I., Wagenblast, Elvin, Kaufmann, Kerstin B., Zeng, Andy G.X., Takayanagi, Shin-ichiro, Patel, Ishita, Lee, Esther K., Jargstorf, Joseph, Holmes, Gareth, Romm, Guy, Pan, Kristele, Shoong, Michelle, Vedi, Aditi, Luberto, Chiara, Minden, Mark D., Bader, Gary D., Laurenti, Elisa, Dick, John E.

“…Cellular stress responses serve as crucial decision points balancing persistence or culling of hematopoietic stem cells (HSCs) for lifelong blood production…”
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A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness by Kaufmann, Kerstin B., Zeng, Andy G. X., Coyaud, Etienne, Garcia-Prat, Laura, Papalexi, Efthymia, Murison, Alex, Laurent, Estelle M. N., Chan-Seng-Yue, Michelle, Gan, Olga I., Pan, Kristele, McLeod, Jessica, Boutzen, Héléna, Zandi, Sasan, Takayanagi, Shin-ichiro, Satija, Rahul, Raught, Brian, Xie, Stephanie Z., Dick, John E.

“…Continuous supply of immune cells throughout life relies on the delicate balance in the hematopoietic stem cell (HSC) pool between long-term maintenance and…”
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The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization by Takayama, Naoya, Murison, Alex, Takayanagi, Shin-ichiro, Arlidge, Christopher, Zhou, Stanley, Garcia-Prat, Laura, Chan-Seng-Yue, Michelle, Zandi, Sasan, Gan, Olga I., Boutzen, Héléna, Kaufmann, Kerstin B., Trotman-Grant, Aaron, Schoof, Erwin, Kron, Ken, Díaz, Noelia, Lee, John J.Y., Medina, Tiago, De Carvalho, Daniel D., Taylor, Michael D., Vaquerizas, Juan M., Xie, Stephanie Z., Dick, John E., Lupien, Mathieu

“…Lifelong blood production requires long-term hematopoietic stem cells (LT-HSCs), marked by stemness states involving quiescence and self-renewal, to transition…”
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Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells by Yamazaki, Satoshi, Iwama, Atsushi, Takayanagi, Shin‐ichiro, Morita, Yohei, Eto, Koji, Ema, Hideo, Nakauchi, Hiromitsu

“…Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) niche in a noncycling state and enter the cell cycle at long intervals. However, little is known…”
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TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate by García-Prat, Laura, Kaufmann, Kerstin B., Schneiter, Florin, Voisin, Veronique, Murison, Alex, Chen, Jocelyn, Chan-Seng-Yue, Michelle, Gan, Olga I., McLeod, Jessica L., Smith, Sabrina A., Shoong, Michelle C., Parris, Darrien, Pan, Kristele, Zeng, Andy G.X., Krivdova, Gabriela, Gupta, Kinam, Takayanagi, Shin-Ichiro, Wagenblast, Elvin, Wang, Weijia, Lupien, Mathieu, Schroeder, Timm, Xie, Stephanie Z., Dick, John E.

“…It is critical to understand how human quiescent long-term hematopoietic stem cells (LT-HSCs) sense demand from daily and stress-mediated cues and then…”
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57R2A, a newly established monoclonal antibody against mouse GPR56, marks long-term repopulating hematopoietic stem cells by Tokoro, Yusuke, Yamada, Yoko, Takayanagi, Shin-ichiro, Hagiwara, Tetsuya

“…•57R2A, a novel monoclonal antibody against mouse GPR56, was established.•Flow cytometry using 57R2A demonstrated GPR56 expression in the mouse hematopoietic…”
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Prevalence of positive IGRAs and innate immune system in HIV-infected individuals in Japan by Igari, Hidetoshi, Takayanagi, Shin, Yahaba, Misuzu, Tsuyuzaki, Mizue, Taniguchi, Toshibumi, Suzuki, Kiminori

“…Human immunodeficiency virus (HIV) infected individuals are at increased risk of developing active tuberculosis (TB). TB incidence remains higher than in…”
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Possibility of deterioration of respiratory status when steroids precede antiviral drugs in patients with COVID-19 pneumonia: A retrospective study by Shionoya, Yu, Taniguchi, Toshibumi, Kasai, Hajime, Sakuma, Noriko, Imai, Shun, Shikano, Kohei, Takayanagi, Shin, Yahaba, Misuzu, Nakada, Taka-aki, Igari, Hidetoshi, Sakao, Seiichiro, Suzuki, Takuji

“…Introduction Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2. Although most patients with COVID-19 develop…”
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Drug Fever Due to Favipiravir Administration for the Treatment of a COVID-19 Patient by Tawara, Junsuke, Uehara, Takanori, Sakao, Seiichiro, Igari, Hidetoshi, Taniguchi, Toshibumi, Kasai, Hajime, Takayanagi, Shin, Yahaba, Misuzu, Shimada, Ryo, Ikusaka, Masatomi

“…A 55-year-old Japanese man was hospitalized with the novel coronavirus disease 2019 (COVID-19). On the 14th day after the start of favipiravir administration,…”
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A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency by Kaufmann, Kerstin B., Garcia-Prat, Laura, Liu, Qiang, Ng, Stanley W.K., Takayanagi, Shin-Ichiro, Mitchell, Amanda, Wienholds, Erno, van Galen, Peter, Cumbaa, Christian A., Tsay, Mike J., Pastrello, Chiara, Wagenblast, Elvin, Krivdova, Gabriela, Minden, Mark D., Lechman, Eric R., Zandi, Sasan, Jurisica, Igor, Wang, Jean C.Y., Xie, Stephanie Z., Dick, John E.

“…There is a growing body of evidence that the molecular properties of leukemia stem cells (LSCs) are associated with clinical outcomes in acute myeloid leukemia…”
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Longitudinal changes in structural lung abnormalities using MDCT in chronic obstructive pulmonary disease with asthma-like features by Anazawa, Rie, Kawata, Naoko, Matsuura, Yukiko, Ikari, Jun, Tada, Yuji, Suzuki, Masaki, Takayanagi, Shin, Matsuoka, Shin, Matsushita, Shoichiro, Tatsumi, Koichiro

“…Some patients with chronic obstructive pulmonary disease (COPD) have asthma-like features. However, there have been few reports on the structural lung…”
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A retrospective observational study of antimicrobial treatment for non-tuberculous mycobacteria disease using a nationwide claims database in Japan by Igari, Hidetoshi, Yamagishi, Kazutaka, Yamazaki, Shingo, Murata, Shota, Yahaba, Misuzu, Takayanagi, Shin, Kawasaki, Yohei, Taniguchi, Toshibumi

“…The Macrolides (MLs), clarithromycin and azithromycin, are key drugs for non-tuberculous mycobacteria (NTM) diseases treatment. A three antibiotics regimen…”
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Epidemiology and treatment outcome of pneumonia: Analysis based on Japan national database by Igari, Hidetoshi, Yamagishi, Kazutaka, Yamazaki, Shingo, Murata, Shota, Yahaba, Misuzu, Takayanagi, Shin, Kawasaki, Yohei, Taniguchi, Toshibumi

“…Pneumonia is the third leading cause of death in Japan. Mortality increases at an accelerating rate in elderly patients aged ≥65 years. Elderly patients tend…”
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Microorganisms isolated at admission and treatment outcome in sputum smear-positive pulmonary tuberculosis by Ishikawa, Satoru, Igari, Hidetoshi, Yamagishi, Kazutaka, Takayanagi, Shin, Yamagishi, Fumio

“…Cured or completed cases in newly diagnosed sputum smear-positive pulmonary tuberculosis (TB) is 47.7% in Japan in 2016. Aging of TB patients and their…”
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Antibiotics prescriptions for pneumonia analyzed by claim information in Japan by Yamazaki, Shingo, Yamagishi, Kazutaka, Murata, Shota, Yokoyama, Iichiro, Yahaba, Misuzu, Takayanagi, Shin, Kawasaki, Yohei, Taniguchi, Toshibumi, Ishii, Itsuko, Igari, Hidetoshi

“…Japan is an aging society, and pneumonia is the leading cause of death, but the suitability of antibiotics for treating community-acquired pneumonia (CAP) in…”
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Mini-TCRs: Truncated T cell receptors to generate T cells from induced pluripotent stem cells by Takayanagi, Shin-ichiro, Wang, Bo, Hasegawa, Saki, Nishikawa, Satoshi, Fukumoto, Ken, Nakano, Kohei, Chuganji, Sayaka, Kato, Yuya, Kamibayashi, Sanae, Minagawa, Atsutaka, Kunisato, Atsushi, Nozawa, Hajime, Kaneko, Shin

“…Allogeneic T cell platforms utilizing induced pluripotent stem cell (iPSC) technology exhibit significant promise for the facilitation of adoptive…”
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A retrospective observational study of antibiotics treatment for sepsis using a nationwide claim database in Japan by Igari, Hidetoshi, Yamagishi, Kazutaka, Yamazaki, Shingo, Yahaba, Misuzu, Takayanagi, Shin, Kawasakis, Yohei, Taniguchi, Toshibumi

“…Survival Sepsis Campaign (SSC) guidelines have recommended broad-spectrum antibiotics prescriptions to cover the possible pathogenic microorganisms. However,…”
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Antibiotics for hospitalized children with community-acquired pneumonia in Japan: Analysis based on Japanese national database by Yahaba, Misuzu, Yamagishi, Kazutaka, Yamazaki, Shingo, Takayanagi, Shin, Kawasaki, Yohei, Taniguchi, Toshibumi, Ishiwada, Naruhiko, Igari, Hidetoshi

“…Community-acquired pneumonia (CAP) is one of the most common causes of pediatric infection requiring hospitalization. Antimicrobial resistance due to the…”
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