Search Results - "Takats, Zoltan"

Metabolic phenotyping in clinical and surgical environments by Nicholson, Jeremy K., Holmes, Elaine, Kinross, James M., Darzi, Ara W., Takats, Zoltan, Lindon, John C.

“…Metabolic phenotyping involves the comprehensive analysis of biological fluids or tissue samples. This analysis allows biochemical classification of a person's…”
Get full text

Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth by Pruski, Pamela, Correia, Gonçalo D. S., Lewis, Holly V., Capuccini, Katia, Inglese, Paolo, Chan, Denise, Brown, Richard G., Kindinger, Lindsay, Lee, Yun S., Smith, Ann, Marchesi, Julian, McDonald, Julie A. K., Cameron, Simon, Alexander-Hardiman, Kate, David, Anna L., Stock, Sarah J., Norman, Jane E., Terzidou, Vasso, Teoh, T. G., Sykes, Lynne, Bennett, Phillip R., Takats, Zoltan, MacIntyre, David A.

“…The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct…”
Get full text

ASO Author Reflections: Diagnostic Accuracy of Nipple Aspirate Fluid Cytology in Asymptomatic Patients and Its Predictive Validity on Future Risk of Breast Cancer: A Meta-Analysis and Systematic Review of the Literature by Jiwa, Natasha, Takats, Zoltan, Leff, Daniel Richard

“…PastNipple aspirate fluid (NAF) is thought to reflect the microenvironment of a developing breast cancer and therefore is considered an important biofluid to…”
Get full text

Real-Time Molecular Diagnosis of Tumors Using Water-Assisted Laser Desorption/Ionization Mass Spectrometry Technology by Saudemont, Philippe, Quanico, Jusal, Robin, Yves-Marie, Baud, Anna, Balog, Julia, Fatou, Benoit, Tierny, Dominique, Pascal, Quentin, Minier, Kevin, Pottier, Mélissa, Focsa, Cristian, Ziskind, Michael, Takats, Zoltan, Salzet, Michel, Fournier, Isabelle

“…Histopathological diagnosis of biopsy samples and margin assessment of surgical specimens are challenging aspects in sarcoma. Using dog patient tissues, we…”
Get full text

Rapid evaporative ionisation mass spectrometry of electrosurgical vapours for the identification of breast pathology: towards an intelligent knife for breast cancer surgery by St John, Edward R, Balog, Julia, McKenzie, James S, Rossi, Merja, Covington, April, Muirhead, Laura, Bodai, Zsolt, Rosini, Francesca, Speller, Abigail V M, Shousha, Sami, Ramakrishnan, Rathi, Darzi, Ara, Takats, Zoltan, Leff, Daniel R

“…Re-operation for positive resection margins following breast-conserving surgery occurs frequently (average = 20-25%), is cost-inefficient, and leads to…”
Get full text

Ambient Mass Spectrometry by Cooks, R. Graham, Ouyang, Zheng, Takats, Zoltan, Wiseman, Justin M

“…A recent innovation in mass spectrometry is the ability to record mass spectra on ordinary samples, in their native environment, without sample preparation or…”
Get full text

The intelligent knife (iKnife) and its intraoperative diagnostic advantage for the treatment of cervical disease by Tzafetas, Menelaos, Mitra, Anita, Paraskevaidi, Maria, Bodai, Zsolt, Kalliala, Ilkka, Bowden, Sarah, Lathouras, Konstantinos, Rosini, Francesca, Szasz, Marcell, Savage, Adele, Balog, Julia, McKenzie, James, Lyons, Deirdre, Bennett, Phillip, MacIntyre, David, Ghaem-Maghami, Sadaf, Takats, Zoltan, Kyrgiou, Maria

“…Clearance of surgical margins in cervical cancer prevents the need for adjuvant chemoradiation and allows fertility preservation. In this study, we determined…”
Get full text

Rapid detection and specific identification of offals within minced beef samples utilising ambient mass spectrometry by Black, Connor, Chevallier, Olivier P., Cooper, Kevin M., Haughey, Simon A., Balog, Julia, Takats, Zoltan, Elliott, Christopher T., Cavin, Christophe

“…The morphological transformation of beef tissues after various processing treatments facilitates the addition of cheap offal products. Undetectable to the…”
Get full text

Human robotic surgery with intraoperative tissue identification using rapid evaporation ionisation mass spectrometry by Manoli, Eftychios, Higginson, James, Tolley, Neil, Darzi, Ara, Kinross, James, Temelkuran, Burak, Takats, Zoltan

“…Instantaneous, continuous, and reliable information on the molecular biology of surgical target tissue could significantly contribute to the precision, safety,…”
Get full text

Mass recalibration for desorption electrospray ionization mass spectrometry imaging using endogenous reference ions by Inglese, Paolo, Huang, Helen Xuexia, Wu, Vincen, Lewis, Matthew R, Takats, Zoltan

“…Mass spectrometry imaging (MSI) data often consist of tens of thousands of mass spectra collected from a sample surface. During the time necessary to perform a…”
Get full text

Lactate dehydrogenase activity staining demonstrates time-dependent immune cell infiltration in human ex-vivo burn-injured skin by Cuddihy, Joshua, Wu, Gongjie, Ho, Laptin, Kudo, Hiromi, Dannhorn, Andreas, Mandalia, Sundhiya, Collins, Declan, Weir, Justin, Spencer, Ashley, Vizcaychipi, Marcela, Takats, Zoltan, Nagy, Istvan

“…Burn injuries constitute one of the most serious accidental injuries. Increased metabolic rate is a hallmark feature of burn injury. Visualising lactate…”
Get full text

Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo by Ashton, Susan, Song, Young Ho, Nolan, Jim, Cadogan, Elaine, Murray, Jim, Odedra, Rajesh, Foster, John, Hall, Peter A, Low, Susan, Taylor, Paula, Ellston, Rebecca, Polanska, Urszula M, Wilson, Joanne, Howes, Colin, Smith, Aaron, Goodwin, Richard J A, Swales, John G, Strittmatter, Nicole, Takáts, Zoltán, Nilsson, Anna, Andren, Per, Trueman, Dawn, Walker, Mike, Reimer, Corinne L, Troiano, Greg, Parsons, Donald, De Witt, David, Ashford, Marianne, Hrkach, Jeff, Zale, Stephen, Jewsbury, Philip J, Barry, Simon T

“…Efforts to apply nanotechnology in cancer have focused almost exclusively on the delivery of cytotoxic drugs to improve therapeutic index. There has been…”
Get more information

Spatially resolved metabolic phenotyping of breast cancer by desorption electrospray ionization mass spectrometry by Guenther, Sabine, Muirhead, Laura J, Speller, Abigail V M, Golf, Ottmar, Strittmatter, Nicole, Ramakrishnan, Rathi, Goldin, Robert D, Jones, Emrys, Veselkov, Kirill, Nicholson, Jeremy, Darzi, Ara, Takats, Zoltan

“…Breast cancer is a heterogeneous disease characterized by varying responses to therapeutic agents and significant differences in long-term survival. Thus,…”
Get full text

In Vivo Endoscopic Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS) by Balog, Julia, Kumar, Sacheen, Alexander, James, Golf, Ottmar, Huang, Juzheng, Wiggins, Tom, Abbassi-Ghadi, Nima, Enyedi, Attila, Kacska, Sandor, Kinross, James, Hanna, George B., Nicholson, Jeremy K., Takats, Zoltan

“…Gastrointestinal cancers are a leading cause of mortality, accounting for 23 % of cancer‐related deaths worldwide. In order to improve outcomes from these…”
Get full text

Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma by Antonowicz, Stefan, Bodai, Zsolt, Wiggins, Tom, Markar, Sheraz R., Boshier, Piers R., Goh, Yan Mei, Adam, Mina E., Lu, Haonan, Kudo, Hiromi, Rosini, Francesca, Goldin, Robert, Moralli, Daniela, Green, Catherine M., Peters, Chris J., Habib, Nagy, Gabra, Hani, Fitzgerald, Rebecca C., Takats, Zoltan, Hanna, George B.

“…Volatile aldehydes are enriched in esophageal adenocarcinoma (EAC) patients’ breath and could improve early diagnosis, however the mechanisms of their…”
Get full text

A novel methodology for in vivo endoscopic phenotyping of colorectal cancer based on real-time analysis of the mucosal lipidome: a prospective observational study of the iKnife by Alexander, James, Gildea, Louise, Balog, Julia, Speller, Abigail, McKenzie, James, Muirhead, Laura, Scott, Alasdair, Kontovounisios, Christos, Rasheed, Shanawaz, Teare, Julian, Hoare, Jonathan, Veselkov, Kirill, Goldin, Robert, Tekkis, Paris, Darzi, Ara, Nicholson, Jeremy, Kinross, James, Takats, Zoltan

“…Background This pilot study assessed the diagnostic accuracy of rapid evaporative ionization mass spectrometry (REIMS) in colorectal cancer (CRC) and colonic…”
Get full text

Histology by Mass Spectrometry: Label-Free Tissue Characterization Obtained from High-Accuracy Bioanalytical Imaging by Römpp, Andreas, Guenther, Sabine, Schober, Yvonne, Schulz, Oliver, Takats, Zoltan, Kummer, Wolfgang, Spengler, Bernhard

“…Next‐generation imaging mass spectrometry of biological tissue on the cellular level shows excellent agreement with histochemical evaluation whilst providing a…”
Get full text

Mass spectrometry transanal minimally invasive surgery (MS-TAMIS) to promote organ preservation in rectal cancer by Mason, Sam, Manoli, Eftychios, Poynter, Liam, Alexander, James, Paizs, Petra, Adebesin, Afeez, Goldin, Robert, Darzi, Ara, Takats, Zoltan, Kinross, James

“…Background Transanal minimally invasive surgery (TAMIS) is deployed for organ preservation in early rectal cancer and significant rectal polyps. Rapid…”
Get full text

Diagnostic Accuracy of Nipple Discharge Fluid Cytology: A Meta-Analysis and Systematic Review of the Literature by Jiwa, Natasha, Kumar, Swathica, Gandhewar, Rishikesh, Chauhan, Hemali, Nagarajan, Vikneswaran, Wright, Corrina, Hadjiminas, Dimitri, Takats, Zoltan, Ashrafian, Hutan, Leff, Daniel Richard

“…Background Nipple discharge is the third most frequent complaint of women attending rapid diagnostic breast clinics. Nipple smear cytology remains the single…”
Get full text

Rapid ex vivo molecular fingerprinting of biofluids using laser-assisted rapid evaporative ionization mass spectrometry by Plekhova, Vera, Van Meulebroek, Lieven, De Graeve, Marilyn, Perdones-Montero, Alvaro, De Spiegeleer, Margot, De Paepe, Ellen, Van de Walle, Emma, Takats, Zoltan, Cameron, Simon J. S., Vanhaecke, Lynn

“…Of the many metabolites involved in any clinical condition, only a narrow range of biomarkers is currently being used in the clinical setting. A key to…”
Get full text