Search Results - "Takatoshi Chinen"

Mucosal IL23A expression predicts the response to Ustekinumab in inflammatory bowel disease by Nishioka, Kei, Ogino, Haruei, Chinen, Takatoshi, Ihara, Eikichi, Tanaka, Yoshimasa, Nakamura, Kazuhiko, Ogawa, Yoshihiro

“…Background Biologics against tumor necrosis factor-α (TNF) and the p40 subunit of interleukin (IL)-12 and IL-23 are increasingly used in inflammatory bowel…”
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Efficacy of endoscopic ultrasound with artificial intelligence for the diagnosis of gastrointestinal stromal tumors by Minoda, Yosuke, Ihara, Eikichi, Komori, Keishi, Ogino, Haruei, Otsuka, Yoshihiro, Chinen, Takatoshi, Tsuda, Yasuo, Ando, Koji, Yamamoto, Hidetaka, Ogawa, Yoshihiro

“…Background Although endoscopic ultrasound (EUS) is reported to be suitable for determining the layer from which subepithelial lesions (SELs) originate, it is…”
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Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis by Nishihara, Yuichiro, Ogino, Haruei, Tanaka, Masaru, Ihara, Eikichi, Fukaura, Keita, Nishioka, Kei, Chinen, Takatoshi, Tanaka, Yoshimasa, Nakayama, Jiro, Kang, Dongchon, Ogawa, Yoshihiro

“…This longitudinal study was designed to elucidate whether gut microbiota is associated with relapse and treatment response in ulcerative colitis (UC) patients…”
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The effects of commensal microbiota on immune cell subsets and inflammatory responses by Chinen, Takatoshi, Rudensky, Alexander Y

“…Billions of years of coevolution shaped the mutually beneficial relationships between metazoans and symbiotic commensal microorganisms. Commensal…”
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Involvement of interstitial cells of Cajal in nicotinic acetylcholine receptor-induced relaxation of the porcine lower esophageal sphincter by Otsuka, Yoshihiro, Bai, Xiaopeng, Tanaka, Yoshimasa, Ihara, Eikichi, Chinen, Takatoshi, Ogino, Haruei, Ogawa, Yoshihiro

“…The interstitial cells of Cajal (ICCs) play an important role in coordinated gastrointestinal motility. The present study aimed to elucidate whether or how…”
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Determination of Region-Specific Roles of the M3 Muscarinic Acetylcholine Receptor in Gastrointestinal Motility by Igarashi-Hisayoshi, Yoko, Ihara, Eikichi, Bai, Xiaopeng, Higashi, Chika, Ikeda, Hiroko, Tanaka, Yoshimasa, Hirano, Mayumi, Ogino, Haruei, Chinen, Takatoshi, Taguchi, Yasushi, Ogawa, Yoshihiro

“…Background The specific role of the M 3 muscarinic acetylcholine receptor in gastrointestinal motility under physiological conditions is unclear, due to a lack…”
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Efficacy of ultrasound endoscopy with artificial intelligence for the differential diagnosis of non-gastric gastrointestinal stromal tumors by Minoda, Yosuke, Ihara, Eikichi, Fujimori, Nao, Nagatomo, Shuzaburo, Esaki, Mitsuru, Hata, Yoshitaka, Bai, Xiaopeng, Tanaka, Yoshimasa, Ogino, Haruei, Chinen, Takatoshi, Hu, Qingjiang, Oki, Eiji, Yamamoto, Hidetaka, Ogawa, Yoshihiro

“…Gastrointestinal stromal tumors (GISTs) are common subepithelial lesions (SELs) and require treatment considering their malignant potential. We recently…”
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Superiority of mucosal incision-assisted biopsy over ultrasound-guided fine needle aspiration biopsy in diagnosing small gastric subepithelial lesions: a propensity score matching analysis by Minoda, Yosuke, Chinen, Takatoshi, Osoegawa, Takashi, Itaba, Soichi, Haraguchi, Kazuhiro, Akiho, Hirotada, Aso, Akira, Sumida, Yorinobu, Komori, Keishi, Ogino, Haruei, Ihara, Eikichi, Ogawa, Yoshihiro

“…Gastric subepithelial lesions, including gastrointestinal stromal tumors, are often found during routine gastroscopy. While endoscopic ultrasound-guided…”
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Objective validity of the Japan Narrow‐Band Imaging Expert Team classification system for the differential diagnosis of colorectal polyps by Minoda, Yosuke, Ogino, Haruei, Chinen, Takatoshi, Ihara, Eikichi, Haraguchi, Kazuhiro, Akiho, Hirotada, Takizawa, Nobuyoshi, Aso, Akira, Tomita, Yosuke, Esaki, Mitsuru, Komori, Keishi, Otsuka, Yoshihiro, Iwasa, Tsutomu, Ogawa, Yoshihiro

“…Background and Aim The Japan Narrow‐Band Imaging (NBI) Expert Team (JNET) classification is a recently proposed NBI magnifying endoscopy‐based classification…”
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The treatment effects of acotiamide in esophagogastric outflow obstruction: a prospective longitudinal observational study by Ihara, Eikichi, Ogino, Haruei, Muta, Kazumasa, Hamada, Shohei, Wada, Masafumi, Hata, Yoshitaka, Ikeda, Hiroko, Bai, Xiaopeng, Minoda, Yosuke, Esaki, Mitsuru, Tanaka, Yoshimasa, Chinen, Takatoshi, Ogawa, Yoshihiro

“…Objectives We have found that an altered lower esophageal sphincter (LES) accommodation response is an underlying cause of esophagogastric junction outflow…”
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STAT6 Inhibits TGF-β1-mediated Foxp3 Induction through Direct Binding to the Foxp3 Promoter, Which Is Reverted by Retinoic Acid Receptor by Takaki, Hiromi, Ichiyama, Kenji, Koga, Keiko, Chinen, Takatoshi, Takaesu, Giichi, Sugiyama, Yuki, Kato, Shigeaki, Yoshimura, Akihiko, Kobayashi, Takashi

“…It has been shown that transforming growth factor β1 (TGF-β1) is critical in the generation of CD4+CD25+Foxp3+-inducible regulatory T cells (iTregs) from naïve…”
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Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance by Yoshimura, Akihiko, Chinen, Takatoshi, Komai, Kyoko, Muto, Go, Morita, Rimpei, Inoue, Naoko, Yoshida, Hideyuki, Sekiya, Takashi, Yoshida, Ryoko, Nakamura, Kazuhiko, Takayanagi, Ryoichi

“…Interleukin 10 (IL-10) and regulatory T cells (Tregs) maintain tolerance to intestinal microorganisms. However, Il10 −/− Rag2 −/− mice, which lack IL-10 and…”
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Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center, randomized, double-blind, placebo-controlled phase II trial by Esaki, Mitsuru, Ihara, Eikichi, Manabe, Noriaki, Kawami, Noriyuki, Iwakiri, Katsuhiko, Akiyama, Junichi, Kuribayashi, Shiko, Uraoka, Toshio, Ogino, Haruei, Chinen, Takatoshi, Misumi, Akiko, Watanabe, Hiroko, Suzuki, Maya, Kishimoto, Junji, Ogawa, Yoshihiro

“…We have determined that the impaired accommodation of the lower esophageal sphincter (LES) underlies the pathogenesis of esophagogastric junction outflow…”
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Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body by Bai, Xiaopeng, Ihara, Eikichi, Otsuka, Yoshihihro, Tsuruta, Shinichi, Hirano, Katsuya, Tanaka, Yoshimasa, Ogino, Haruei, Hirano, Mayumi, Chinen, Takatoshi, Akiho, Hirotada, Nakamura, Kazuhiko, Oda, Yoshinao, Ogawa, Yoshihiro

“…Prostaglandin E2 (PGE2) plays a role in the pathogenesis of gastro-esophageal reflux disease (GERD). There are 4 subtypes of PGE2, PGE2 receptor 1, 2, 3 and 4…”
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IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages by Yoshimura, Akihiko, Yasukawa, Hideo, Ohishi, Masanobu, Mori, Hiroyuki, Murakami, Masaaki, Chinen, Takatoshi, Aki, Daisuke, Hanada, Toshikatsu, Takeda, Kiyoshi, Akira, Shizuo, Hoshijima, Masahiko, Hirano, Toshio, Chien, Kenneth R

“…Whereas interleukin-6 (IL-6) is a proinflammatory cytokine, IL-10 is an anti-inflammatory cytokine. Although signal transducer and activator of transcription 3…”
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Role of the IL-23-T-bet/GATA3 Axis for the Pathogenesis of Ulcerative Colitis by Ogino, Haruei, Fukaura, Keita, Iboshi, Yoichiro, Nagamatsu, Yousuke, Okuno, Hiroaki, Nishioka, Kei, Nishihara, Yuichiro, Tanaka, Yoshimasa, Chinen, Takatoshi, Ihara, Eikich, Ogawa, Yoshihiro

“…Ulcerative colitis (UC) has been considered a Th2- and Th17-related disease. However, anti-IL-12/23 p40 antibody, which blocks Th1 and Th17 cell induction and…”
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Onigiri esophagography as a screening test for esophageal motility disorders by Hamada, Shohei, Ihara, Eikichi, Muta, Kazumasa, Wada, Masafumi, Hata, Yoshitaka, Ikeda, Hiroko, Tanaka, Yoshimasa, Ogino, Haruei, Chinen, Takatoshi, Ogawa, Yoshihiro

“…No screening test for esophageal motility disorder (EMD) has been established, the objective of this study is to examine the potential usefulness of our newly…”
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Deletion of the SOCS3 Gene in Liver Parenchymal Cells Promotes Hepatitis–Induced Hepatocarcinogenesis by Ogata, Hisanobu, Kobayashi, Takashi, Chinen, Takatoshi, Takaki, Hiromi, Sanada, Takahito, Minoda, Yasumasa, Koga, Keiko, Takaesu, Giichi, Maehara, Yoshihiko, Iida, Mitsuo, Yoshimura, Akihiko

“…Background & Aims: A recent study has suggested that the methylation silencing of the suppressor of cytokine signaling-3 (SOCS3), a negative regulator of…”
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Discriminant equation using mucosally expressed cytokines and transcription factor for making definite diagnosis of inflammatory bowel disease unclassified by Okuno, Hiroaki, Ogino, Haruei, Ihara, Eikichi, Nishioka, Kei, Tanaka, Yoshimasa, Chinen, Takatoshi, Kohjima, Motoyuki, Oono, Takamasa, Tanaka, Masatake, Goya, Takeshi, Fujimori, Nao, Iboshi, Yoichiro, Gotoda, Takuji, Ogawa, Yoshihiro

“…The pathological conditions of UC and CD involved in inflammatory bowel disease-unclassified (IBD-U), UC with primary sclerosing cholangitis (PSC-UC), and UC…”
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Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice by Horino, Jiro, Fujimoto, Minoru, Terabe, Fumitaka, Serada, Satoshi, Takahashi, Tsuyoshi, Soma, Yoshihito, Tanaka, Kentaro, Chinen, Takatoshi, Yoshimura, Akihiko, Nomura, Shintaro, Kawase, Ichiro, Hayashi, Norio, Kishimoto, Tadamitsu, Naka, Tetsuji

“…Inflammatory bowel disease (IBD) is a chronic disorder of the gastrointestinal tract. Although the etiology and pathogenesis of IBD remain unknown,…”
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