Search Results - "Takarada‐Iemata, Mika"

Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide‐induced microglial and astrocytic neuroinflammation by increasing NAD by Roboon, Jureepon, Hattori, Tsuyoshi, Ishii, Hiroshi, Takarada‐Iemata, Mika, Nguyen, Dinh Thi, Heer, Collin D., O'Meally, Denis, Brenner, Charles, Yamamoto, Yasuhiko, Okamoto, Hiroshi, Higashida, Haruhiro, Hori, Osamu

“…Neuroinflammation is initiated by activation of the brain's innate immune system in response to an inflammatory challenge. Insufficient control of…”
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Roles of N-myc downstream-regulated gene 2 in the central nervous system: molecular basis and relevance to pathophysiology by Takarada-Iemata, Mika

“…N-myc downstream-regulated gene 2 (NDRG2) is a member of the NDRG family, whose members have multiple functions in cell proliferation, differentiation, and…”
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Postnatal expression of CD38 in astrocytes regulates synapse formation and adult social memory by Hattori, Tsuyoshi, Cherepanov, Stanislav M, Sakaga, Ryo, Roboon, Jureepon, Nguyen, Dinh Thi, Ishii, Hiroshi, Takarada‐Iemata, Mika, Nishiuchi, Takumi, Kannon, Takayuki, Hosomichi, Kazuyoshi, Tajima, Atsushi, Yamamoto, Yasuhiko, Okamoto, Hiroshi, Sugawara, Akira, Higashida, Haruhiro, Hori, Osamu

“…Social behavior is essential for health, survival, and reproduction of animals; however, the role of astrocytes in social behavior remains largely unknown. The…”
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Brain injury triggers cell‐type‐specific and time‐dependent endoplasmic reticulum stress responses by Fan, Qiyan, Takarada‐Iemata, Mika, Okitani, Nahoko, Tamatani, Takashi, Ishii, Hiroshi, Hattori, Tsuyoshi, Kiryu‐Seo, Sumiko, Kiyama, Hiroshi, Hori, Osamu

“…The unfolded protein response (UPR) is a signal transduction network that responds to endoplasmic reticulum (ER) stress by coordinating protein homeostasis to…”
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The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity by Nguyen, Dinh Thi, Le, Thuong Manh, Hattori, Tsuyoshi, Takarada-Iemata, Mika, Ishii, Hiroshi, Roboon, Jureepon, Tamatani, Takashi, Kannon, Takayuki, Hosomichi, Kazuyoshi, Tajima, Atsushi, Taniuchi, Shusuke, Miyake, Masato, Oyadomari, Seiichi, Tanaka, Takashi, Kato, Nobuo, Saito, Shunsuke, Mori, Kazutoshi, Hori, Osamu

“…While ATF6α plays a central role in the endoplasmic reticulum (ER) stress response, the function of its paralogue ATF6β remains elusive, especially in the…”
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N‐myc downstream‐regulated gene 2 protects blood–brain barrier integrity following cerebral ischemia by Takarada‐Iemata, Mika, Yoshikawa, Akifumi, Ta, Hieu Minh, Okitani, Nahoko, Nishiuchi, Takumi, Aida, Yasuhiro, Kamide, Tomoya, Hattori, Tsuyoshi, Ishii, Hiroshi, Tamatani, Takashi, Le, Thuong Manh, Roboon, Jureepon, Kitao, Yasuko, Matsuyama, Tomohiro, Nakada, Mitsutoshi, Hori, Osamu

“…Disruption of the blood‐brain barrier (BBB) following cerebral ischemia is closely related to the infiltration of peripheral cells into the brain, progression…”
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Deletion of N‐myc downstream‐regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury by Takarada‐Iemata, Mika, Kezuka, Dai, Takeichi, Toshiaki, Ikawa, Masahito, Hattori, Tsuyoshi, Kitao, Yasuko, Hori, Osamu

“…N‐myc downstream‐regulated gene 2 (Ndrg2) is a differentiation‐ and stress‐associated molecule predominantly expressed in astrocytes in the CNS. In this study,…”
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Ndrg2 deficiency ameliorates neurodegeneration in experimental autoimmune encephalomyelitis by Le, Thuong Manh, Takarada‐Iemata, Mika, Ta, Hieu Minh, Roboon, Jureepon, Ishii, Hiroshi, Tamatani, Takashi, Kitao, Yasuko, Hattori, Tsuyoshi, Hori, Osamu

“…N‐myc downstream‐regulated gene 2 (NDRG2) is a differentiation‐ and stress‐associated molecule that is predominantly expressed in astrocytes in the central…”
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Microglial activation in the cochlear nucleus after early hearing loss in rats by Noda, Masao, Hatano, Miyako, Hattori, Tsuyoshi, Takarada-Iemata, Mika, Shinozaki, Tomohiro, Sugimoto, Hisashi, Ito, Makoto, Yoshizaki, Tomokazu, Hori, Osamu

“…Microglia are highly specialized tissue macrophages in the central nervous system. Their activation in the auditory system has been reported in adult hearing…”
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Osteoclastogenesis is negatively regulated by D-serine produced by osteoblasts by Takarada, Takeshi, Takarada-Iemata, Mika, Takahata, Yoshifumi, Yamada, Daisuke, Yamamoto, Tomomi, Nakamura, Yukari, Hinoi, Eiichi, Yoneda, Yukio

“…We have shown the functional expression by chondrocytes of serine racemase (SR) which is responsible for the synthesis of D‐serine (Ser) from L‐Ser in…”
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Glutamate preferentially suppresses osteoblastogenesis than adipogenesis through the cystine/glutamate antiporter in mesenchymal stem cells by Takarada-Iemata, Mika, Takarada, Takeshi, Nakamura, Yukari, Nakatani, Eri, Hori, Osamu, Yoneda, Yukio

“…We have shown that glutamate (Glu) signaling machineries, such as receptors (GluR) and transporters, are functionally expressed by mesenchymal stem cells, in…”
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A Negative Correlation Between Per1 and Sox6 Expression During Chondrogenic Differentiation in Pre-chondrocytic ATDC5 Cells by Le, Nguyen Quynh, Binh, Nguyen Thanh, Takarada, Takeshi, Takarada-Iemata, Mika, Hinoi, Eiichi, Yoneda, Yukio

“…Pre-chondrocytes undergo cellular differentiation stages during chondrogenesis under the influence by different transcription factors such as sry-type high…”
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Deletion of Herp facilitates degradation of cytosolic proteins by Miura, Hikari, Hashida, Koji, Sudo, Hirofumi, Awa, Yoshitaka, Takarada-Iemata, Mika, Kokame, Koichi, Takahashi, Tetsuya, Matsumoto, Masayasu, Kitao, Yasuko, Hori, Osamu

“…Although intracellular stresses are believed to be involved in the process of neurodegeneration, it is not fully understood how one stress/stress response…”
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Sympathetic Nervous Hyperactivity Impairs Microcirculation Leading to Early Brain Injury After Subarachnoid Hemorrhage by Demura, Munehiro, Ishii, Hiroshi, Takarada-Iemata, Mika, Kamide, Tomoya, Yoshikawa, Akifumi, Nakada, Mitsutoshi, Hori, Osamu

“…Although early brain injury (EBI) is recognized as a critical step following subarachnoid hemorrhage (SAH), its pathophysiology and underlying mechanisms…”
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Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice by Yoshikawa, Akifumi, Kamide, Tomoya, Hashida, Koji, Ta, Hieu Minh, Inahata, Yuki, Takarada‐Iemata, Mika, Hattori, Tsuyoshi, Mori, Kazutoshi, Takahashi, Ryosuke, Matsuyama, Tomohiro, Hayashi, Yutaka, Kitao, Yasuko, Hori, Osamu

“…To dissect the role of endoplasmic reticulum (ER) stress and unfolded protein response in brain ischemia, we investigated the relevance of activating…”
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Atf6α deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis by Ta, Hieu Minh, Le, Thuong Manh, Ishii, Hiroshi, Takarada‐Iemata, Mika, Hattori, Tsuyoshi, Hashida, Koji, Yamamoto, Yasuhiko, Mori, Kazutoshi, Takahashi, Ryosuke, Kitao, Yasuko, Hori, Osamu

“…Accumulating evidence suggests a critical role for the unfolded protein response in multiple sclerosis (MS) and in its animal model, experimental autoimmune…”
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CD38 positively regulates postnatal development of astrocytes cell‐autonomously and oligodendrocytes non‐cell‐autonomously by Hattori, Tsuyoshi, Kaji, Minoru, Ishii, Hiroshi, Jureepon, Roboon, Takarada‐Iemata, Mika, Minh Ta, Hieu, Manh Le, Thuong, Konno, Ayumu, Hirai, Hirokazu, Shiraishi, Yoshitake, Ozaki, Noriyuki, Yamamoto, Yasuhiko, Okamoto, Hiroshi, Yokoyama, Shigeru, Higashida, Haruhiro, Kitao, Yasuko, Hori, Osamu

“…Glial development is critical for the function of the central nervous system. CD38 is a multifunctional molecule with ADP‐ribosyl cyclase activity. While…”
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Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination by Roboon, Jureepon, Hattori, Tsuyoshi, Ishii, Hiroshi, Takarada-Iemata, Mika, Le, Thuong Manh, Shiraishi, Yoshitake, Ozaki, Noriyuki, Yamamoto, Yasuhiko, Sugawara, Akira, Okamoto, Hiroshi, Higashida, Haruhiro, Kitao, Yasuko, Hori, Osamu

“…CD38 is an enzyme that catalyzes the synthesis of cyclic adenosine diphosphate-ribose from nicotinamide adenine dinucleotide (NAD ). We recently reported that…”
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Abnormal social behavior and altered gene expression in mice lacking NDRG2 by Takarada-Iemata, Mika, Yoshihara, Toru, Okitani, Nahoko, Iwata, Keiko, Hattori, Tsuyoshi, Ishii, Hiroshi, Roboon, Jureepon, Nguyen, Dinh Thi, Fan, Qiyan, Tamatani, Takashi, Nishiuchi, Takumi, Asano, Masahide, Hori, Osamu

“…•NDRG2 expression increased during postnatal brain development.•NDRG2 deficiency altered gene expression in the brain, including Bmp4 and Per2.•NDRG2 knockout…”
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Isolation of ferret astrocytes reveals their morphological, transcriptional, and functional differences from mouse astrocytes by Roboon, Jureepon, Hattori, Tsuyoshi, Nguyen, Dinh Thi, Ishii, Hiroshi, Takarada-Iemata, Mika, Kannon, Takayuki, Hosomichi, Kazuyoshi, Maejima, Takashi, Saito, Kengo, Shinmyo, Yohei, Mieda, Michihiro, Tajima, Atsushi, Kawasaki, Hiroshi, Hori, Osamu

“…Astrocytes play key roles in supporting the central nervous system structure, regulating synaptic functions, and maintaining brain homeostasis. The number of…”
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