Search Results - "Takara, Kazuhiro"

Apelin as a marker for monitoring the tumor vessel normalization window during antiangiogenic therapy by Zhang, Li, Takara, Kazuhiro, Yamakawa, Daishi, Kidoya, Hiroyasu, Takakura, Nobuyuki

“…Antiangiogenic agents transiently normalize tumor vessel structure and improve vessel function, thereby providing a window of opportunity for enhancing the…”
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Endothelial Side Population Cells Contribute to Tumor Angiogenesis and Antiangiogenic Drug Resistance by Naito, Hisamichi, Wakabayashi, Taku, Kidoya, Hiroyasu, Muramatsu, Fumitaka, Takara, Kazuhiro, Eino, Daisuke, Yamane, Keitaro, Iba, Tomohiro, Takakura, Nobuyuki

“…Angiogenesis plays a crucial role in tumor growth, with an undisputed contribution of resident endothelial cells (EC) to new blood vessels in the tumor. Here,…”
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Neurovascular Interactions in the Development of the Vasculature by Takara, Kazuhiro, Hayashi-Okada, Yumiko, Kidoya, Hiroyasu

“…Vertebrates have developed a network of blood vessels and nerves throughout the body that enables them to perform complex higher-order functions and maintain…”
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LPA4-Mediated Vascular Network Formation Increases the Efficacy of Anti-PD-1 Therapy against Brain Tumors by Eino, Daisuke, Tsukada, Yohei, Naito, Hisamichi, Kanemura, Yonehiro, Iba, Tomohiro, Wakabayashi, Taku, Muramatsu, Fumitaka, Kidoya, Hiroyasu, Arita, Hideyuki, Kagawa, Naoki, Fujimoto, Yasunori, Takara, Kazuhiro, Kishima, Haruhiko, Takakura, Nobuyuki

“…: The structure and function of tumor blood vessels profoundly affects the tumor microenvironment. Signals mediated through the lysophosphatidic acid receptor…”
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Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake by Takara, Kazuhiro, Hatakeyama, Hiroto, Ohga, Noritaka, Hida, Kyoko, Harashima, Hideyoshi

“…In this study, a dual-ligand liposomal system comprised of a specific ligand and a cell penetrating peptide (CPP) is described to enhance selectivity and…”
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Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy by Kanzaki, Ryu, Naito, Hisamichi, Kise, Kazuyoshi, Takara, Kazuhiro, Eino, Daisuke, Minami, Masato, Shintani, Yasushi, Funaki, Soichiro, Kawamura, Tomohiro, Kimura, Toru, Okumura, Meinoshin, Takakura, Nobuyuki

“…Alterations to the tumor stromal microenvironment induced by chemotherapy could influence the behavior of cancer cells. In the tumor stromal microenvironment,…”
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Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact by Takara, Kazuhiro, Eino, Daisuke, Ando, Koji, Yasuda, Daisuke, Naito, Hisamichi, Tsukada, Yohei, Iba, Tomohiro, Wakabayashi, Taku, Muramatsu, Fumitaka, Kidoya, Hiroyasu, Fukuhara, Shigetomo, Mochizuki, Naoki, Ishii, Satoshi, Kishima, Haruhiko, Takakura, Nobuyuki

“…Vascular normalization in tumors may improve drug delivery and anti-tumor immunity. Angiogenesis inhibitors induce hypoxia, which may facilitate malignant…”
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Tumor endothelial cell-specific drug delivery system using apelin-conjugated liposomes by Kawahara, Hiroki, Naito, Hisamichi, Takara, Kazuhiro, Wakabayashi, Taku, Kidoya, Hiroyasu, Takakura, Nobuyuki

“…A drug delivery system specifically targeting endothelial cells (ECs) in tumors is required to prevent normal blood vessels from being damaged by angiogenesis…”
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Changes in blood vessel maturation in the fibrous cap of the tumor rim by Naito, Hisamichi, Takara, Kazuhiro, Wakabayashi, Taku, Kawahara, Hiroki, Kidoya, Hiroyasu, Takakura, Nobuyuki

“…It is widely accepted that blood vessels in the tumor microenvironment are immature because mural cell (MC) adhesion to endothelial cells (ECs) is broadly…”
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Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise for use in drug-resistant cancer therapy by Takara, Kazuhiro, Hatakeyama, Hiroto, Kibria, Golam, Ohga, Noritaka, Hida, Kyoko, Harashima, Hideyoshi

“…Anti-angiogenic therapy is a potential chemotherapeutic strategy for the treatment of drug resistant cancers. However, a method for delivering such drugs to…”
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CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties by Wakabayashi, Taku, Naito, Hisamichi, Suehiro, Jun-ichi, Lin, Yang, Kawaji, Hideya, Iba, Tomohiro, Kouno, Tsukasa, Ishikawa-Kato, Sachi, Furuno, Masaaki, Takara, Kazuhiro, Muramatsu, Fumitaka, Weizhen, Jia, Kidoya, Hiroyasu, Ishihara, Katsuhiko, Hayashizaki, Yoshihide, Nishida, Kohji, Yoder, Mervin C., Takakura, Nobuyuki

“…The generation of new blood vessels via angiogenesis is critical for meeting tissue oxygen demands. A role for adult stem cells in this process remains…”
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PSF1 (Partner of SLD Five 1) is a Prognostic Biomarker in Patients with Non-small Cell Lung Cancer Treated with Surgery Following Preoperative Chemotherapy or Chemoradiotherapy by Kanzaki, Ryu, Naito, Hisamichi, Kise, Kazuyoshi, Takara, Kazuhiro, Eino, Daisuke, Minami, Masato, Shintani, Yasushi, Funaki, Soichiro, Kawamura, Tomohiro, Kimura, Toru, Okumura, Meinoshin, Takakura, Nobuyuki

“…Background PSF1 (Partner of SLD Five 1) is an evolutionarily conserved DNA replication factor that is part of the GINS (Go, Ichi, Nii, and San) complex . The…”
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Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice by Matsushita, Jun, Inagaki, Shigenori, Nishie, Tomomi, Sakasai, Tomoki, Tanaka, Junko, Watanabe, Chisato, Mizutani, Ken-ichi, Miwa, Yoshihiro, Matsumoto, Ken, Takara, Kazuhiro, Naito, Hisamichi, Kidoya, Hiroyasu, Takakura, Nobuyuki, Nagai, Takeharu, Takahashi, Satoru, Ema, Masatsugu

“…Angiogenesis is important for normal development as well as for tumour growth. However, the molecular and cellular mechanisms underlying angiogenesis are not…”
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Identification of vascular endothelial side population cells in the choroidal vessels and their potential role in age-related macular degeneration by Wakabayashi, Taku, Naito, Hisamichi, Takara, Kazuhiro, Kidoya, Hiroyasu, Sakimoto, Susumu, Oshima, Yusuke, Nishida, Kohji, Takakura, Nobuyuki

“…The neovascular form of age-related macular degeneration (AMD) is characterized by the growth of abnormal new blood vessels from the choroid, termed choroidal…”
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Alteration of blood vessel maturation in fibrous cap. Resistance of mature blood vessels in the fibrous cap after treatment with a VEGFR inhibitor, Axitinib by Naito, Hisamichi, Takara, Kazuhiro, Wakabayashi, Taku, Kawahara, Hiroki, Kidoya, Hiroyasu, Takakura, Nobuyuki

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Tumor Endothelial Cell-Specific Drug Delivery System Using Apelin-Conjugated Liposomes. e65499 by Kawahara, Hiroki, Naito, Hisamichi, Takara, Kazuhiro, Wakabayashi, Taku, Kidoya, Hiroyasu, Takakura, Nobuyuki

“…Background A drug delivery system specifically targeting endothelial cells (ECs) in tumors is required to prevent normal blood vessels from being damaged by…”
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