Search Results - "Takaoka, Katsuyoshi"
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Cell fate decisions and axis determination in the early mouse embryo
Published in Development (Cambridge) (01-01-2012)“…The mouse embryo generates multiple cell lineages, as well as its future body axes in the early phase of its development. The early cell fate decisions lead to…”
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Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos
Published in Nature communications (14-11-2017)“…Anterior–posterior (A–P) polarity of mouse embryos is established by distal visceral endoderm (DVE) at embryonic day (E) 5.5. Lefty1 is expressed first at E3.5…”
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Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex
Published in Nature communications (01-07-2021)“…Molecular left-right (L-R) asymmetry is established at the node of the mouse embryo as a result of the sensing of a leftward fluid flow by immotile cilia of…”
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RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity
Published in The EMBO journal (02-01-2015)“…Formation of a new centriole adjacent to a pre‐existing centriole occurs only once per cell cycle. Despite being crucial for genome integrity, the mechanisms…”
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A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking
Published in Developmental cell (13-03-2017)“…Polarization of node cells along the anterior-posterior axis of mouse embryos is responsible for left-right symmetry breaking. How node cells become polarized…”
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Origin of cellular asymmetries in the pre-implantation mouse embryo: a hypothesis
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (05-12-2014)“…The first cell fate decision during mouse development concerns whether a blastomere will contribute to the inner cell mass (ICM; which gives rise to the embryo…”
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CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module
Published in Nature communications (02-11-2020)“…Axonemal dynein ATPases direct ciliary and flagellar beating via adenosine triphosphate (ATP) hydrolysis. The modulatory effect of adenosine monophosphate…”
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Author Correction: A newly identified gene Ahed plays essential roles in murine haematopoiesis
Published in Nature communications (23-10-2024)Get full text
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Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells
Published in Development (Cambridge) (01-05-2022)“…For left-right symmetry breaking in the mouse embryo, the basal body must become positioned at the posterior side of node cells, but the precise mechanism for…”
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A newly identified gene Ahed plays essential roles in murine haematopoiesis
Published in Nature communications (25-06-2024)“…The development of haematopoiesis involves the coordinated action of numerous genes, some of which are implicated in haematological malignancies. However, the…”
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CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components
Published in PLoS genetics (21-12-2020)“…Motile cilia can beat with distinct patterns, but how motility variations are regulated remain obscure. Here, we have studied the role of the coiled-coil…”
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A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO
Published in The Journal of cell biology (05-12-2016)“…Glycosylphosphatidylinositol-anchored proteins (GPI-APs) can be shed from the cell membrane by GPI cleavage. In this study, we report a novel GPI-processing…”
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Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo
Published in The Journal of cell biology (26-01-2009)“…The anterior-posterior axis of the mouse embryo is established by formation of distal visceral endoderm (DVE) and its subsequent migration. The precise…”
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Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning
Published in Genes & development (15-07-2009)“…The abundance of retinoic acid (RA) is determined by the balance between its synthesis by retinaldehyde dehydrogenase (RALDH) and its degradation by CYP26. In…”
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Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6
Published in Genes to cells : devoted to molecular & cellular mechanisms (01-07-2016)“…Lrrc6 encodes a cytoplasmic protein that is expressed specifically in cells with motile cilia including the node, trachea and testes of the mice. A mutation of…”
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Ciliogenesis‐coupled accumulation of IFT‐B proteins in a novel cytoplasmic compartment
Published in Genes to cells : devoted to molecular & cellular mechanisms (01-11-2019)“…Cluap1/IFT38 is a ciliary protein that belongs to the IFT‐B complex and is required for ciliogenesis. In this study, we have examined the behaviors of Cluap1…”
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Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development
Published in eLife (22-06-2016)“…Transcription factors organize gene expression profiles by regulating promoter activity. However, the role of transcription factors after transcription…”
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S254: A NEW GENE AHED PLAYS ESSENTIAL ROLES IN HEMATOPOIESIS THROUGH RNA‐SPLICING
Published in HemaSphere (08-08-2023)Get full text
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The Mouse Embryo Autonomously Acquires Anterior-Posterior Polarity at Implantation
Published in Developmental cell (01-04-2006)“…The earliest recognizable sign of patterning of the mouse embryo along the anteroposterior (A-P) axis is the migration of the distal visceral endoderm (DVE)…”
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Fluid flow and interlinked feedback loops establish left–right asymmetric decay of Cerl2 mRNA
Published in Nature communications (27-12-2012)Get full text
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