Low Intensity Physical Exercise Attenuates Cardiac Remodeling and Myocardial Oxidative Stress and Dysfunction in Diabetic Rats

Low Intensity Physical Exercise Attenuates Cardiac Remodeling and Myocardial Oxidative Stress and Dysfunction in Diabetic Rats

We evaluated the effects of a low intensity aerobic exercise protocol on cardiac remodeling and myocardial function in diabetic rats. Wistar rats were assigned into four groups: sedentary control (C-Sed), exercised control (C-Ex), sedentary diabetes (DM-Sed), and exercised diabetes (DM-Ex). Diabetes...

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Bibliographic Details
Published in:Journal of diabetes research Vol. 2015; no. 2015; pp. 1 - 10
Main Authors: Takamoto, A. H. R., Okoshi, Marina Politi, Okoshi, K., Guirado, G. N., Cezar, M. D. M., Fernandes, Ana Angélica Henrique, Campos, D. H. S., Xavier, N. P., Rosa, C. M., Gimenes, R., Gimenes, C., Cicogna, Antonio Carlos
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2015
Hindawi Limited
Subjects:
Animals
Cardiac function
Cardiomyopathy
Cardiovascular disease
Diabetes
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - physiopathology
Diabetes Mellitus, Experimental - therapy
Exercise
Exercise Therapy
Glucose
Heart - physiopathology
Heart failure
Kruskal-Wallis test
Male
Medical research
Metabolism
Myocardium - metabolism
Oxidative stress
Oxidative Stress - physiology
Physical Conditioning, Animal - physiology
Rats
Rats, Wistar
Studies
Ventricular Remodeling - physiology
Brazil
United States > US
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Summary:We evaluated the effects of a low intensity aerobic exercise protocol on cardiac remodeling and myocardial function in diabetic rats. Wistar rats were assigned into four groups: sedentary control (C-Sed), exercised control (C-Ex), sedentary diabetes (DM-Sed), and exercised diabetes (DM-Ex). Diabetes was induced by intraperitoneal injection of streptozotocin. Rats exercised for 9 weeks in treadmill at 11 m/min, 18 min/day. Myocardial function was evaluated in left ventricular (LV) papillary muscles and oxidative stress in LV tissue. Statistical analysis was given by ANOVA or Kruskal-Wallis. Echocardiogram showed diabetic groups with higher LV diastolic diameter-to-body weight ratio and lower posterior wall shortening velocity than controls. Left atrium diameter was lower in DM-Ex than DM-Sed (C-Sed: 5.73±0.49; C-Ex: 5.67±0.53; DM-Sed: 6.41±0.54; DM-Ex: 5.81±0.50 mm; P<0.05 DM-Sed vs C-Sed and DM-Ex). Papillary muscle function was depressed in DM-Sed compared to C-Sed. Exercise attenuated this change in DM-Ex. Lipid hydroperoxide concentration was higher in DM-Sed than C-Sed and DM-Ex. Catalase and superoxide dismutase activities were lower in diabetics than controls and higher in DM-Ex than DM-Sed. Glutathione peroxidase activity was lower in DM-Sed than C-Sed and DM-Ex. Conclusion. Low intensity exercise attenuates left atrium dilation and myocardial oxidative stress and dysfunction in type 1 diabetic rats.
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Academic Editor: Bagher Larijani
ISSN:2314-6745
2314-6753
DOI:10.1155/2015/457848