Search Results - "Takamori, Kenji"

Peripheral itch sensitization in atopic dermatitis by Tominaga, Mitsutoshi, Takamori, Kenji

“…Atopic dermatitis is a skin disorder caused by skin dryness and barrier dysfunction, resulting in skin inflammation and chronic itch (or pruritus). The…”
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Itch and nerve fibers with special reference to atopic dermatitis: Therapeutic implications by Tominaga, Mitsutoshi, Takamori, Kenji

“…Nerve density in the epidermis is partly involved in itch sensitization in pruritic skin diseases, such as atopic dermatitis (AD). Epidermal innervation is…”
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Molecular and Cellular Mechanisms of Itch in Psoriasis by Komiya, Eriko, Tominaga, Mitsutoshi, Kamata, Yayoi, Suga, Yasushi, Takamori, Kenji

“…Itch (or pruritus) was not previously recognized as a serious symptom of psoriasis. However, approximately 60-90% of psoriatic patients with pruritus have…”
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Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation by Toyama, Sumika, Tominaga, Mitsutoshi, Takamori, Kenji

“…Although histamine is a well-known itch mediator, histamine H -receptor blockers often lack efficacy in chronic itch. Recent molecular and cellular based…”
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Efficacy of nalfurafine hydrochloride in patients with chronic liver disease with refractory pruritus: A randomized, double‐blind trial by Kumada, Hiromitsu, Miyakawa, Hiroshi, Muramatsu, Taro, Ando, Naoki, Oh, Takanori, Takamori, Kenji, Nakamoto, Hidetomo

“…Aims Patients with chronic liver disease sometimes develop cholestasis, which induces severe whole‐body pruritus that may disrupt daily activities and sleep…”
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Mechanisms and Management of Itch in Dry Skin by Moniaga, Catharina Sagita, Tominaga, Mitsutoshi, Takamori, Kenji

“…Chronic itch is a burdensome clinical problem that often accompanies pathological dry skin-based conditions, such as atopic dermatitis, and systemic disorders,…”
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An Altered Skin and Gut Microbiota Are Involved in the Modulation of Itch in Atopic Dermatitis by Moniaga, Catharina Sagita, Tominaga, Mitsutoshi, Takamori, Kenji

“…Skin and gut microbiota play an important role in the pathogenesis of atopic dermatitis (AD). An alteration of the microbiota diversity modulates the…”
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Roles of glutamate, substance P, and gastrin-releasing peptide as spinal neurotransmitters of histaminergic and nonhistaminergic itch by Akiyama, Tasuku, Tominaga, Mitsutoshi, Takamori, Kenji, Carstens, Mirela Iodi, Carstens, E.

“…Histamine-independent itch was mediated by the combined action of glutamate, substance P, and gastrin-releasing peptide while histamine-dependent itch relied…”
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An Update on Peripheral Mechanisms and Treatments of Itch by Tominaga, Mitsutoshi, Takamori, Kenji

“…Histamine H1-receptor blockers are used to treat all types of itch resulting from serious skin diseases such as atopic dermatitis, as well as from renal and…”
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Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells by Umehara, Yoshie, Toyama, Sumika, Tominaga, Mitsutoshi, Matsuda, Hironori, Takahashi, Nobuaki, Kamata, Yayoi, Niyonsaba, François, Ogawa, Hideoki, Takamori, Kenji

“…Because intractable itch reduces quality of life, understanding the fundamental mechanisms of itch is required to develop antipruritic treatments. Itch is…”
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Treatment Options for Troublesome Itch by Toyama, Sumika, Tominaga, Mitsutoshi, Takamori, Kenji

“…Itch (or pruritus) is an unpleasant sensation, inducing the desire to scratch. It is also a major and distressing symptom of many skin and systemic diseases…”
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Human β-defensin-3 attenuates atopic dermatitis–like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway by Peng, Ge, Tsukamoto, Saya, Ikutama, Risa, Nguyen, Hai Le Thanh, Umehara, Yoshie, Trujillo-Paez, Juan V., Yue, Hainan, Takahashi, Miho, Ogawa, Takasuke, Kishi, Ryoma, Tominaga, Mitsutoshi, Takamori, Kenji, Kitaura, Jiro, Kageyama, Shun, Komatsu, Masaaki, Okumura, Ko, Ogawa, Hideoki, Ikeda, Shigaku, Niyonsaba, François

“…Human β-defensin-3 (hBD-3) exhibits antimicrobial and immunomodulatory activities; however, its contribution to autophagy regulation remains unclear, and the…”
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Psoralen-ultraviolet A therapy alters epidermal Sema3A and NGF levels and modulates epidermal innervation in atopic dermatitis by Tominaga, Mitsutoshi, Tengara, Suhandy, Kamo, Atsuko, Ogawa, Hideoki, Takamori, Kenji

“…Abstract Background Epidermal nerve densities are increased in patients with atopic dermatitis (AD), suggesting that it is partly responsible for the intense…”
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MicroRNA-766-3p Contributes to Anti-Inflammatory Responses through the Indirect Inhibition of NF-κB Signaling by Hayakawa, Kunihiro, Kawasaki, Mikiko, Hirai, Takuya, Yoshida, Yuko, Tsushima, Hiroshi, Fujishiro, Maki, Ikeda, Keigo, Morimoto, Shinji, Takamori, Kenji, Sekigawa, Iwao

“…MicroRNA (miRNA) is small RNA of 20 to 22 nucleotides in length and is stably present in plasma. Regulating the expression of miRNA taken into cells has been…”
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Extract of Scutellaria baicalensis induces semaphorin 3A production in human epidermal keratinocytes by Yoshioka, Yasuko, Kamata, Yayoi, Tominaga, Mitsutoshi, Umehara, Yoshie, Yoshida, Ikuyo, Matsuoka, Nobuya, Takamori, Kenji

“…In a disease-state-dependent manner, the histamine-resistant itch in dry skin-based skin diseases such as atopic dermatitis (AD) and xerosis is mainly due to…”
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Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model by Jang, Hyosun, Matsuda, Akira, Jung, Kyungsook, Karasawa, Kaoru, Matsuda, Kenshiro, Oida, Kumiko, Ishizaka, Saori, Ahn, Ginnae, Amagai, Yosuke, Moon, Changjong, Kim, Sung-Ho, Arkwright, Peter D., Takamori, Kenji, Matsuda, Hiroshi, Tanaka, Akane

“…Elevated skin surface pH has been reported in patients with atopic dermatitis. In this study, we explored the role of skin pH in the pathogenesis of atopic…”
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The Pathology of Type 2 Inflammation-Associated Itch in Atopic Dermatitis by Moniaga, Catharina Sagita, Tominaga, Mitsutoshi, Takamori, Kenji

“…Accumulated evidence on type 2 inflammation-associated itch in atopic dermatitis has recently been reported. Crosstalk between the immune and nervous systems…”
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Caution and warning: Arrival of terbinafine‐resistant Trichophyton interdigitale of the Indian genotype, isolated from extensive dermatophytosis, in Japan by Kimura, Utako, Hiruma, Masataro, Kano, Rui, Matsumoto, Tadahiko, Noguchi, Hiromitsu, Takamori, Kenji, Suga, Yasushi

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The simultaneous quantification of candidate serum biomarker peptides for hypertensive disorders of pregnancy by Yanagida, Mitsuaki, Hamamura, Kensuke, Takamori, Kenji, Araki, Yoshihiko

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Model of Chronic Itch in Aged Mice: Beneficial Effects of Drugs Affecting Descending Modulatory Systems by Kojima, Go, Komiya, Eriko, Honda, Kotaro, Kaneko, Takahide, Suga, Yasushi, Tominaga, Mitsutoshi, Takamori, Kenji

“…Pruritus in the elderly, particularly those cases without skin dryness or other identifiable causes, makes treatment challenging due to the lack of evidence…”
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