Photon-Counting Detector CT: Potential for 75% Reduction in Contrast Medium Amount: A Phantom Study

This study aimed to evaluate the potential reduction in contrast medium utilization using photon-counting detector computed tomography (PCD-CT). One PCD-CT scan (CT1) and three conventional (non-PCD-CT) CT scans (CT2-CT4) were performed using a multi-energy CT phantom that contained eight rods with...

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Bibliographic Details
Published in:	Acta medica Okayama Vol. 78; no. 2; pp. 135 - 142
Main Authors:	Higaki, Fumiyo, Morimitsu, Yusuke, Iguchi, Toshihiro, Saito, Hayato, Takaki, Haruhiko, Nakagoshi, Ayako, Wada, Maki, Uka, Mayu, Akagi, Noriaki, Mitsuhashi, Toshiharu, Matsui, Yusuke, Hiraki, Takao
Format:	Journal Article
Language:	English
Published:	Japan 01-04-2024
Subjects:	Contrast Media - chemistry Humans Iodine Phantoms, Imaging Photons Tomography, X-Ray Computed - methods computed tomography contrast medium amount energy integrating detector CT photon-counting detector CT reduction
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Summary:	This study aimed to evaluate the potential reduction in contrast medium utilization using photon-counting detector computed tomography (PCD-CT). One PCD-CT scan (CT1) and three conventional (non-PCD-CT) CT scans (CT2-CT4) were performed using a multi-energy CT phantom that contained eight rods with different iodine concentrations (0.2, 0.5, 1, 2, 5, 10, 15, and 20 mg/ml). The CT values of the seven groups (CT1 for 40, 50, 60, and 70 keV; and CT2-4) were measured. Noise and contrast-to-noise ratio (CNR) were assessed for the eight rods at various iodine concentrations. CT2 and CT1 (40 keV) respectively required 20 mg/ml and 5 mg/ml of iodine, indicating that a comparable contrast effect could be obtained with approximately one-fourth of the contrast medium amount. The standard deviation values increased at lower energy levels irrespective of the iodine concentration. The CNR exhibited a decreasing trend with lower iodine concentrations, while it remained relatively stable across all iodine levels (40-70 keV). This study demonstrated that virtual monochromatic 40 keV images offer a similar contrast effect with a reduced contrast medium amount when compared to conventional CT systems at 120 kV.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0386-300X
DOI:	10.18926/amo/66916