Search Results - "Takai, Shinji"

Chymase as a Possible Therapeutic Target for Amelioration of Non-Alcoholic Steatohepatitis by Takai, Shinji, Jin, Denan

“…The development and progression of non-alcoholic steatohepatitis (NASH) are linked to oxidative stress, inflammation, and fibrosis of the liver. Chymase, a…”
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In Vivo and In Vitro Evaluation of Urinary Biomarkers in Ischemia/Reperfusion-Induced Kidney Injury by Hosohata, Keiko, Jin, Denan, Takai, Shinji

“…Oxidative stress plays an important role in the pathophysiology of acute kidney injury (AKI). Previously, we reported that vanin-1, which is involved in…”
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Glaucocalyxin A Ameliorates Hypoxia/Reoxygenation-Induced Injury in Human Renal Proximal Tubular Epithelial Cell Line HK-2 Cells by Hosohata, Keiko, Jin, Denan, Takai, Shinji

“…Ischemia-reperfusion injury is one of the major causes of acute kidney injury (AKI), which is increasingly prevalent in clinical settings. Glaucocalxin A…”
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Tryptase-Positive Mast Cells Promote Adipose Fibrosis in Secondary Lymphedema through PDGF by Nuri, Takashi, Jin, Denan, Takai, Shinji, Ueda, Koichi

“…Lymphedema is a chronic and progressive condition that causes physical disfigurement and psychological trauma due to the accumulation of lymphatic fluid in the…”
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Pathophysiological Role of Chymase-Activated Matrix Metalloproteinase-9 by Takai, Shinji, Jin, Denan

“…Chymase present in mast cells can directly form matrix metalloproteinase (MMP)-9 from proMMP-9. Chymase-activated MMP-9 has been reportedly closely related to…”
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Involvement of Vanin-1 in Ameliorating Effect of Oxidative Renal Tubular Injury in Dahl-Salt Sensitive Rats by Hosohata, Keiko, Jin, Denan, Takai, Shinji, Iwanaga, Kazunori

“…In salt-sensitive hypertension, reactive oxygen species (ROS) play a major role in the progression of renal disease partly through the activation of the…”
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Immunohistological Study of Monkey Foveal Retina by Ikeda, Tsunehiko, Nakamura, Kimitoshi, Oku, Hidehiro, Horie, Taeko, Kida, Teruyo, Takai, Shinji

“…The fovea centralis, an anatomically concave pit located at the center of the macula, is avascular, hypoxic, and characteristic of stem-cell niches of other…”
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Hypermetabolism of glutathione, glutamate and ornithine via redox imbalance in methylglyoxal-induced peritoneal injury rats by Hirahara, Ichiro, Kusano, Eiji, Jin, Denan, Takai, Shinji

“…Abstract Peritoneal dialysis (PD) is a blood purification treatment for patients with reduced renal function. However, the peritoneum is exposed to oxidative…”
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Vanin-1 in Renal Pelvic Urine Reflects Kidney Injury in a Rat Model of Hydronephrosis by Hosohata, Keiko, Jin, Denan, Takai, Shinji, Iwanaga, Kazunori

“…Urinary tract obstruction and the subsequent development of hydronephrosis can cause kidney injuries, which results in chronic kidney disease. Although it is…”
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Blastocyst-like Structures in the Peripheral Retina of Young Adult Beagles by Ikeda, Tsunehiko, Jin, Denan, Takai, Shinji, Nakamura, Kimitoshi, Nemoto, Emika, Kojima, Shota, Oku, Hidehiro

“…In this immunohistological study on the peripheral retina of 3-year-old beagle dogs, excised retina specimens were immunostained with antibodies against…”
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Range of serum transthyretin levels in hemodialysis patients at a high risk of 1‐year mortality: A retrospective cohort study by Kumagai, Etsuko, Hosohata, Keiko, Furumachi, Kazuhiro, Takai, Shinji

“…Introduction Transthyretin (TTR) is a sensitive marker of nutritional status and independent risk factor for mortality in hemodialysis patients. However, its…”
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Significance of Vascular Dipeptidyl Peptidase-4 Inhibition on Vascular Protection in Zucker Diabetic Fatty Rats by Takai, Shinji, Sakonjo, Hiroshi, Jin, Denan

“…To clarify the role of dipeptidyl peptidase-4 (DPP-4) inhibition in vascular tissues, we compared the effects of the poorly tissue-penetrative DPP-4 inhibitor…”
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Lactobacillus gasseri SBT2055 reduces infection by and colonization of Campylobacter jejuni by Nishiyama, Keita, Seto, Yasuyuki, Yoshioka, Kazuki, Kakuda, Tsutomu, Takai, Shinji, Yamamoto, Yuji, Mukai, Takao

“…Campylobacter is a normal inhabitant of the chicken gut. Pathogenic infection with this organism in humans is accompanied by severe inflammation of the…”
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Involvement of Glycogen Synthase Kinase 3β (GSK3β) in Formation of Phosphorylated Tau and Death of Retinal Ganglion Cells of Rats Caused by Optic Nerve Crush by Fukiyama, Yurie, Hirokawa, Takahisa, Takai, Shinji, Kida, Teruyo, Oku, Hidehiro

“…Tauopathy is a neurodegenerative condition associated with oligomeric tau formation through abnormal phosphorylation. We previously showed that tauopathy is…”
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Early urinary biomarkers of renal tubular damage by a high‐salt intake independent of blood pressure in normotensive rats by Washino, Satoshi, Hosohata, Keiko, Jin, Denan, Takai, Shinji, Miyagawa, Tomoaki

“…Summary Dietary sodium intake has been associated with progression to chronic kidney disease (CKD) as well as hypertension. A high‐salt intake causes renal…”
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Effectiveness of monitoring free carnitine levels for L‐carnitine supplementation in hemodialysis patients to maintain carnitine sufficiency and nutritional factors by Kumagai, Etsuko, Hosohata, Keiko, Furumachi, Kazuhiro, Takai, Shinji

“…We investigated the effectiveness of monitoring serum carnitine levels in hemodialysis patients receiving L‐carnitine supplementation. One‐hundred forty‐five…”
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TMEM182 inhibits myocardial differentiation of human iPS cells by maintaining the activated state of Wnt/β‐catenin signaling through an increase in ILK expression by Morihara, Hirofumi, Yokoe, Shunichi, Wakabayashi, Shigeo, Takai, Shinji

“…Transmembrane protein 182 (TMEM182) is notably abundant in muscle and adipose tissue, but its role in the heart remains unknown. This study examined the…”
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Chymase Inhibitor as a Novel Therapeutic Agent for Non-alcoholic Steatohepatitis by Takai, Shinji, Jin, Denan

“…Non-alcoholic steatohepatitis (NASH) is characterized by inflammation and fibrosis, in addition to steatosis, of the liver, but no therapeutic agents have yet…”
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Activation of Mast-Cell-Derived Chymase in the Lacrimal Glands of Patients with IgG4-Related Ophthalmic Disease by Fujita, Yasushi, Jin, Denan, Mimura, Masashi, Sato, Yohei, Takai, Shinji, Kida, Teruyo

“…The purpose of this present study was to investigate the distribution and expression of chymase in the lacrimal glands (LGs) of patients afflicted with…”
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Increase in Chymase-Positive Mast Cells in Recurrent Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland by Kinoshita, Ichita, Jin, Denan, Higashino, Masaaki, Terada, Tetsuya, Kurisu, Yoshitaka, Takai, Shinji, Kawata, Ryo

“…Incomplete excision of pleomorphic adenoma (PA) may result in recurrent pleomorphic adenoma (RPA). Furthermore, long-term neglected PA may become carcinoma ex…”
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