Search Results - "Takahisa Hirose"

Effectiveness of dapagliflozin on vascular endothelial function and glycemic control in patients with early-stage type 2 diabetes mellitus: DEFENCE study by Shigiyama, Fumika, Kumashiro, Naoki, Miyagi, Masahiko, Ikehara, Kayoko, Kanda, Eiichiro, Uchino, Hiroshi, Hirose, Takahisa

“…Recent studies reported that sodium glucose cotransporter 2 (SGLT2) inhibitors can potentially reduce the risk of cardiovascular mortality in patients with…”
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Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4 by ARAKAWA, Masayuki, MITA, Tomoya, AZUMA, Kosuke, EBATO, Chie, GOTO, Hiromasa, NOMIYAMA, Takashi, FUJITANI, Yoshio, HIROSE, Takahisa, KAWAMORI, Ryuzo, WATADA, Hirotaka

“…Exogenous administration of glucagon-like peptide-1 (GLP-1) or GLP-1 receptor agonists such as an exendin-4 has direct beneficial effects on the cardiovascular…”
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Development of new basal insulin peglispro (LY2605541) ends in a disappointing result by Hirose, Takahisa

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Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet by Ebato, Chie, Uchida, Toyoyoshi, Arakawa, Masayuki, Komatsu, Masaaki, Ueno, Takashi, Komiya, Koji, Azuma, Kosuke, Hirose, Takahisa, Tanaka, Keiji, Kominami, Eiki, Kawamori, Ryuzo, Fujitani, Yoshio, Watada, Hirotaka

“…Autophagy is an evolutionarily conserved machinery for bulk degradation of cytoplasmic components. Here, we report upregulation of autophagosome formation in…”
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A prospective randomized study comparing effects of empagliflozin to sitagliptin on cardiac fat accumulation, cardiac function, and cardiac metabolism in patients with early-stage type 2 diabetes: the ASSET study by Hiruma, Shigenori, Shigiyama, Fumika, Hisatake, Shinji, Mizumura, Sunao, Shiraga, Nobuyuki, Hori, Masaaki, Ikeda, Takanori, Hirose, Takahisa, Kumashiro, Naoki

“…While the cardioprotective benefits of sodium-glucose cotransporter-2 (SGLT2) inhibitors have been established in patients with cardiovascular disease (CVD),…”
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Mechanisms of sleep deprivation-induced hepatic steatosis and insulin resistance in mice by Shigiyama, Fumika, Kumashiro, Naoki, Tsuneoka, Yousuke, Igarashi, Hiroyuki, Yoshikawa, Fukumi, Kakehi, Saori, Funato, Hiromasa, Hirose, Takahisa

“…Sleep deprivation is associated with increased risk for type 2 diabetes mellitus. However, the underlying mechanisms of sleep deprivation-induced glucose…”
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Efficacy of dapagliflozin versus sitagliptin on cardiometabolic risk factors in Japanese patients with type 2 diabetes: a prospective, randomized study (DIVERSITY-CVR) by Fuchigami, Ayako, Shigiyama, Fumika, Kitazawa, Toru, Okada, Yosuke, Ichijo, Takamasa, Higa, Mariko, Hiyoshi, Toru, Inoue, Ikuo, Iso, Kaoru, Yoshii, Hidenori, Hirose, Takahisa, Kumashiro, Naoki

“…Few prospective studies have compared the cardiovascular benefits of sodium-glucose cotransporter-2 (SGLT2) inhibitors and dipeptidyl peptidase 4 (DPP-4)…”
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Simplification of complex insulin regimens using canagliflozin or liraglutide in patients with well‐controlled type 2 diabetes: A 24‐week randomized controlled trial by Ando, Yasuyo, Shigiyama, Fumika, Hirose, Takahisa, Kumashiro, Naoki

“…Aims/Introduction We investigated the potential use of canagliflozin, in comparison with liraglutide, as an alternative to bolus insulin in patients with…”
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A comparison of meal tolerance test and oral glucose tolerance test for predicting insulin therapy in patients with gestational diabetes by Hijikata, Mai, Higa, Mariko, Ichijo, Takamasa, Hirose, Takahisa

“…To identify factors predicting a need for insulin therapy in gestational diabetes mellitus (GDM) by comparing plasma glucose (PG) levels in a 75-g oral glucose…”
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Comparison of Glycated Albumin (GA) and Glycated Hemoglobin (HbA1c) in Type 2 Diabetic Patients: Usefulness of GA for Evaluation of Short-term Changes in Glycemic Control by TAKAHASHI, Satomi, UCHINO, Hiroshi, SHIMIZU, Tomoaki, KANAZAWA, Akio, TAMURA, Yoshifumi, SAKAI, Ken, WATADA, Hirotaka, HIROSE, Takahisa, KAWAMORI, Ryuzo, TANAKA, Yasushi

“…We studied the cross-sectional relationship between GA and HbA1c in 142 type 2 diabetic patients who had an HbA1c level <7.5% for at least one year without…”
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Characteristics of physical prefrailty among Japanese healthy older adults by Matsushita, Eiji, Okada, Kiwako, Ito, Yui, Satake, Shosuke, Shiraishi, Nariaki, Hirose, Takahisa, Kuzuya, Masafumi

“…Aim The purpose of the present study was to clarify the characteristics of frailty at an early stage (prefrailty) in a healthy elderly Japanese population…”
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Whole hepatic lipid volume quantification and color mapping by multi‐slice and multi‐point magnetic resonance imaging by Igarashi, Hiroyuki, Shigiyama, Fumika, Wakui, Noritaka, Nagai, Hidenari, Shibuya, Kazutoshi, Shiraga, Nobuyuki, Hirose, Takahisa, Kumashiro, Naoki

“…Aim Current approaches for hepatic steatosis assess only a small point within the liver and might cause inaccuracy for longitudinal observation. We aimed to…”
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Rationale and design of study of dapagliflozin versus sitagliptin treatment efficacy on prevention of cardiovascular risk factors in type 2 diabetes patients: the DIVERSITY-CVR study by Shigiyama, Fumika, Kumashiro, Naoki, Fuchigami, Ayako, Hirose, Takahisa

“…Recent studies reported that sodium glucose cotransporter 2 (SGLT2) inhibitors reduced the cardiovascular morbidity and mortality in patients with type 2…”
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Changes in subjective sleep quality in patients with type 2 diabetes who did not use Sleep agents: a cross-sectional study according to age and clinical background by Yoshikawa, Fukumi, Kumashiro, Naoki, Shigiyama, Fumika, Miyagi, Masahiko, Ando, Yasuyo, Uchino, Hiroshi, Hirose, Takahisa

“…Aim Diabetes and aging are both well-established risk factors for insomnia. Therefore, we investigated the changes in subjective sleep quality in relation to…”
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Quantitative evaluation of insulin‐induced abdominal subcutaneous dystrophic tissue using shear wave elastography by Sato, Genki, Uchino, Hiroshi, Shimizu, Yosuke, Tatebe, Junko, Morita, Toshisuke, Hirose, Takahisa

“…ABSTRACT Aims/Introduction Subcutaneous dystrophic tissue (DT) produced by insulin injection causes dysglycemia owing to inadequate absorption of insulin…”
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Successful Treatment of Amiodarone-induced Thyrotoxicosis Type 1 in Combination with Methimazole and Potassium Iodide in a Patient with Hashimoto's Thyroiditis by Katoh, Daisuke, Yoshino, Hiroshi, Ikehara, Kayoko, Kumashiro, Naoki, Uchino, Hiroshi, Tsuboi, Kumiko, Hirose, Takahisa

“…A patient with underlying Hashimoto's thyroiditis developed amiodarone-induced thyrotoxicosis type 1 that was successfully treated using methimazole in…”
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Age‐related changes of proinsulin processing in diabetic and non‐diabetic Japanese individuals by Yoshino, Hiroshi, Kawakami, Kyoko, Yoshino, Gen, Hirose, Takahisa

“…Aim The present study was carried out to examine whether the insulin secretory mechanism deteriorates during the aging process using the new intact proinsulin…”
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Giant Cavernous Hemangioma of the Adrenal Gland in an Elderly Patient by Hashimoto, Ayana, Yoshino, Hiroshi, Yoshikawa, Fukumi, Kumashiro, Naoki, Ando, Yasuyo, Yamabe, Fumito, Akishima-Fukasawa, Yuri, Honma, Naoko, Uchino, Hiroshi, Hirose, Takahisa

“…Cavernous hemangioma is a rare, non-functional, benign adrenal tumor. Adrenal cavernous hemangioma is often diagnosed after surgery with a histologic…”
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SGLT2 inhibitor versus carbohydrate-restricted isocaloric diet: reprogramming substrate oxidation in type 2 diabetes by Igarashi, Hiroyuki, Uchino, Hiroshi, Kanaguchi, Momoko, Hisanaga, Kaori, Sato, Genki, Yoshikawa, Fukumi, Furuta, Masashi, Washizawa, Naohiro, Usui, Shuki, Miyagi, Masahiko, Hirose, Takahisa

“…Based on the whole-body energy metabolism and insulin action, the difference between increased excretion of carbohydrate in urine by SGLT2i and reduced same…”
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Linagliptin improves endothelial function in patients with type 2 diabetes: A randomized study of linagliptin effectiveness on endothelial function by Shigiyama, Fumika, Kumashiro, Naoki, Miyagi, Masahiko, Iga, Ryo, Kobayashi, Yuka, Kanda, Eiichiro, Uchino, Hiroshi, Hirose, Takahisa

“…Aims/Introduction The present multicenter, prospective, controlled, open and randomized three‐arm parallel study was designed to compare the effects of…”
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