Search Results - "Takahiro Goto"
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Universal Approximation Property of Quantum Machine Learning Models in Quantum-Enhanced Feature Spaces
Published in Physical review letters (27-08-2021)“…Encoding classical data into quantum states is considered a quantum feature map to map classical data into a quantum Hilbert space. This feature map provides…”
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Integrated exome and RNA sequencing of dedifferentiated liposarcoma
Published in Nature communications (12-12-2019)“…The genomic characteristics of dedifferentiated liposarcoma (DDLPS) that are associated with clinical features remain to be identified. Here, we conduct…”
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Applications of a grid-based CYP3A4 Template system to understand the interacting mechanisms of large-size ligands; part 4 of CYP3A4 Template study
Published in Drug metabolism and pharmacokinetics (01-12-2020)“…Catalytic interactions of CYP3A4 with large-size ligands have been studied on the Template established in our previous studies using polyaromatic hydrocarbon…”
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Reconstitution of CYP3A4 active site through assembly of ligand interactions as a grid-template: Solving the modes of the metabolism and inhibition
Published in Drug metabolism and pharmacokinetics (01-04-2019)“…A hexagonal-grid based template system has been developed to a predicting tool of CYP3A4-mediated reactions through the reconstitution of the active site with…”
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Combination Strategy with Complexation Hydrogels and Cell-Penetrating Peptides for Oral Delivery of Insulin
Published in Biological & pharmaceutical bulletin (01-05-2018)“…In previous studies we showed that the complexation hydrogels based in poly(methacrylic acid-g-ethylene glycol) [P(MAA-g-EG)] rapidly release insulin in the…”
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Versatile applicability of a grid-based CYP3A4 Template to understand the interacting mechanisms with the small-size ligands; part 3 of CYP3A4 Template study
Published in Drug metabolism and pharmacokinetics (01-06-2020)“…Modes of interactions of small ligands with CYP3A4 have been defined using the Template established in our previous studies (DMPK. 34: 113–125 2019 and…”
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Preoperative serum interleukin-6 level in head and neck cancer reflects systemic inflammatory response and is a predictor of postoperative prognosis
Published in Japanese journal of clinical oncology (07-03-2023)“…Abstract Background The outcome of head and neck cancer has improved in recent years but survival is not yet satisfactory. Interleukin (IL)-6 is a…”
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Effectiveness of genetic feedback on alcohol metabolism to reduce alcohol consumption in young adults: an open-label randomized controlled trial
Published in BMC medicine (20-05-2024)“…It is unclear whether brief interventions using the combined classification of alcohol-metabolizing enzymes aldehyde dehydrogenase 2 (ALDH2) and alcohol…”
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Solving the interactions of steroidal ligands with CYP3A4 using a grid-base template system
Published in Drug metabolism and pharmacokinetics (01-12-2019)“…Using over fifty steroidal ligands, CYP3A4 Template system established in our previous study (DMPK 34: 113-125, 2019) has been evaluated for the applicability…”
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Study protocol of brief intervention using gene polymorphism information for excessive drinking among Japanese college students and adults aged 20–30 years: a randomized controlled trial
Published in Current controlled trials in cardiovascular medicine (26-08-2022)“…Abstract Background The alcohol-metabolizing enzyme aldehyde dehydrogenase 2 ( ALDH2 ) is a carcinogenic acetaldehyde-degrading enzyme, and its low activity is…”
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Saturated hydraulic conductivity of compacted bentonite–sand mixtures before and after gas migration in artificial seawater
Published in Journal of Rock Mechanics and Geotechnical Engineering (01-01-2023)“…To understand the self-healing property of an engineered barrier for radioactive waste disposal, the hydraulic conductivity of compacted bentonite–sand…”
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Optimal Schedule of Preoperative Embolization for Spinal Metastasis Surgery
Published in Spine (Philadelphia, Pa. 1976) (15-10-2013)“…STUDY DESIGN.A retrospective study. OBJECTIVE.To investigate the relationship between intraoperative blood loss during spinal metastasis surgery and the…”
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Worldwide collaboration for orphan drug designation
Published in Nature reviews. Drug discovery (01-06-2016)Get full text
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Massively parallel sequencing of tenosynovial giant cell tumors reveals novel CSF1 fusion transcripts and novel somatic CBL mutations
Published in International journal of cancer (15-12-2019)“…Tenosynovial giant cell tumor (TSGCT) is a rare neoplasm. Although surgical resection is the widely accepted primary treatment for TSGCT, recurrences are…”
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What Factors Are Associated with Treatment Outcomes of Japanese Patients with Clear Cell Chondrosarcoma?
Published in Clinical orthopaedics and related research (01-11-2020)“…Clear cell chondrosarcoma is an extremely rare chondrosarcoma subtype; thus, its treatment outcomes and associated factors have not been widely studied…”
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A dynamical systems approach for estimating phase interactions between rhythms of different frequencies from experimental data
Published in PLoS computational biology (01-01-2018)“…Synchronization of neural oscillations as a mechanism of brain function is attracting increasing attention. Neural oscillation is a rhythmic neural activity…”
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Control of Lanthanide Coordination Environment: Synthesis, Structure, and Oxygen-Sensitive Luminescence Properties of an Eight-Coordinate Tb(III) Complex
Published in Inorganic chemistry (05-07-2016)“…Coordination environment of the Tb3+ ion in oxygen-sensitive luminescent complexes can be successfully controlled through the size of alkyl substituents on…”
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Characteristics verification of pneumatic artificial muscles for compressive loading
Published in Advanced robotics (18-07-2023)“…A McKibben pneumatic actuator (MPA) is an artificial muscle. Many studies have attempted to investigate the tension exerted by the MPA. However, the MPA also…”
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Validation of synthesized normal‐resolution image data generated from high‐resolution acquisitions on a commercial CT scanner
Published in Medical physics (Lancaster) (01-10-2020)“…Purpose To validate a normal‐resolution (NR) simulation (NRsim) algorithm that uses high‐resolution (HR) or super‐high resolution (SHR) acquisitions on a…”
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