Search Results - "Takahashi, Virginia"

S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking by Cohen, Taylor S., Boland, Michelle L., Boland, Brandon B., Takahashi, Virginia, Tovchigrechko, Andrey, Lee, Young, Wilde, Aimee D., Mazaitis, Mark J., Jones-Nelson, Omari, Tkaczyk, Christine, Raja, Rajiv, Stover, C. Kendall, Sellman, Bret R.

“…Clinical severity of Staphylococcus aureus respiratory infection correlates with alpha toxin (AT) expression. AT activates the NLRP3 inflammasome; deletion of…”
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A West Nile Virus Recombinant Protein Vaccine That Coactivates Innate and Adaptive Immunity by Huleatt, James W., Foellmer, Harald G., Hewitt, Duane, Tang, Jie, Desai, Priyanka, Price, Albert, Jacobs, Andrea, Takahashi, Virginia N., Huang, Yan, Nakaar, Valerian, Alexopoulou, Lena, Fikrig, Erol, Powell, T. J., McDonald, William F.

“…A chimeric protein West Nile virus (WNV) vaccine capable of delivering both innate and adaptive immune signals was designed by fusing a modified version of…”
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SARS-CoV-2 Spike Protein Expression In Vitro and Hematologic Effects in Mice Vaccinated With AZD1222 (ChAdOx1 nCoV-19) by Stebbings, Richard, Jones, Christopher, Cotton, Peter, Armour, Gillian, Maguire, Shaun, Skellett, Vicky, Tang, Chi-Man, Goodman, Joanne, Brady, Tyler, Takahashi, Virginia, Daunt, Andrew, Lapointe, Jean-Martin, Cohen, Taylor S

“…Severe COVID-19 can be associated with a prothrombotic state, increasing risk of morbidity and mortality. The SARS-CoV-2 spike glycoprotein is purported to…”
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PD-L1 + neutrophils contribute to injury-induced infection susceptibility by Thanabalasuriar, Ajitha, Chiang, Abby J, Morehouse, Christopher, Camara, Margarita, Hawkins, Shonda, Keller, Ashley E, Koksal, Adem C, Caceres, Carolina S, Berlin, Aaron A, Holoweckyj, Nicholas, Takahashi, Virginia N, Cheng, Lily, de Los Reyes, Melissa, Pelletier, Mark, Patera, Andriani C, Sellman, Bret, Hess, Sonja, Marelli, Marcello, Boo, Chelsea C, Cohen, Taylor S, DiGiandomenico, Antonio

“…The underlying mechanisms contributing to injury-induced infection susceptibility remain poorly understood. Here, we describe a rapid increase in neutrophil…”
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Efficacious recombinant influenza vaccines produced by high yield bacterial expression: a solution to global pandemic and seasonal needs by Song, Langzhou, Nakaar, Valerian, Kavita, Uma, Price, Albert, Huleatt, Jim, Tang, Jie, Jacobs, Andrea, Liu, Ge, Huang, Yan, Desai, Priyanka, Maksymiuk, Gail, Takahashi, Virginia, Umlauf, Scott, Reiserova, Lucia, Bell, Rodney, Li, Hong, Zhang, Yi, McDonald, William F, Powell, T J, Tussey, Lynda

“…It is known that physical linkage of TLR ligands and vaccine antigens significantly enhances the immunopotency of the linked antigens. We have used this…”
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Direct binding of a hepatitis C virus inhibitor to the viral capsid protein by Kota, Smitha, Takahashi, Virginia, Ni, Feng, Snyder, John K, Strosberg, A Donny

“…Over 130 million people are infected chronically with hepatitis C virus (HCV), which, together with HBV, is the leading cause of liver disease. Novel small…”
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Core as a novel viral target for hepatitis C drugs by Strosberg, Arthur Donny, Kota, Smitha, Takahashi, Virginia, Snyder, John K, Mousseau, Guillaume

“…Hepatitis C virus (HCV) infects over 130 million people worldwide and is a major cause of liver disease. No vaccine is available. Novel specific drugs for HCV…”
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Staphylococcus aureus drives expansion of low-density neutrophils in diabetic mice by Cohen, Taylor S, Takahashi, Virginia, Bonnell, Jessica, Tovchigrechko, Andrey, Chaerkady, Raghothama, Yu, Wen, Jones-Nelson, Omari, Lee, Young, Raja, Rajiv, Hess, Sonja, Stover, C Kendall, Worthington, John J, Travis, Mark A, Sellman, Bret R

“…Diabetic individuals are at considerable risk for invasive infection by Staphylococcus aureus, however, the mechanisms underlying this enhanced susceptibility…”
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1110. AZD7442 (Tixagevimab/Cilgavimab) Demonstrates Potent In Vitro Activity Against SARS-CoV-2 Spike Variants Identified in Circulation and in Prophylaxis Clinical Studies by Tuffy, Kevin M, Abram, Michael E, Roe, Tiffany L, Ahani, Bahar, Brady, Tyler, Schuko, Nicolette, Clarke, Lori, Caceres, Carolina, Kenny, Tara, Takahashi, Virginia, Zhang, Tianhui, Tabor, David E, Kijak, Gustavo H, Kelly, Elizabeth J, Streicher, Katie

“…Abstract Background AZD7442 is a combination of extended–half-life SARS-CoV-2–neutralizing monoclonal antibodies (tixagevimab/cilgavimab) that bind to distinct…”
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Potent inhibitors of hepatitis C core dimerization as new leads for anti-hepatitis C agents by Ni, Feng, Kota, Smitha, Takahashi, Virginia, Strosberg, A. Donny, Snyder, John K.

“…New indoline alkaloid-type compounds which inhibit HCV production by infected hepatoma cells have been identified. These compounds, dimeric-type compounds of…”
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New small molecule inhibitors of hepatitis C virus by Wei, Wanguo, Cai, Cuifang, Kota, Smitha, Takahashi, Virginia, Ni, Feng, Strosberg, A. Donny, Snyder, John K.

“…New small molecule inhibitors of HCV were discovered by screening a small library of indoline alkaloid-type compounds. An automated assay format was employed…”
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PAZ6 cells constitute a representative model for human brown pre-adipocytes by Kazantzis, Melissa, Takahashi, Virginia, Hinkle, Jessica, Kota, Smitha, Zilberfarb, Vladimir, Issad, Tarik, Abdelkarim, Mouaadh, Chouchane, Lotfi, Strosberg, Arthur Donny

“…The role of brown adipose tissue (BAT) in human metabolism and its potential as an anti-obesity target organ have recently received much renewed attention…”
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A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization by Kota, Smitha, Scampavia, Louis, Spicer, Timothy, Beeler, Aaron B, Takahashi, Virginia, Snyder, John K, Porco, John A, Hodder, Peter, Strosberg, Arthur Donny

“…Binding of hepatitis C virus (HCV) RNA to core, the capsid protein, results in the formation of the nucleocapsid, the first step in the assembly of the viral…”
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Truncated Aspidosperma Alkaloid-Like Scaffolds: Unique Structures for the Discovery of New, Bioactive Compounds by K. Snyder, John, C. Benson, Scott, Lee, Lily, Wei, Wanguo, Ni, Feng, David Janna Olmos, Julian, R. Strom, Kyle, B. Beeler, Aaron, Chih-Chien Cheng, Ken, Inglese, James, Kota, Smitha, Takahashi, Virginia, Donny Strosberg, A., H. Connor, John, Guy Bushkin, G.

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