Search Results - "Takahashi, Ryou‐U"

Development of miRNA‐based therapeutic approaches for cancer patients by Takahashi, Ryou‐u, Prieto‐Vila, Marta, Kohama, Isaku, Ochiya, Takahiro

“…Over the past few decades, siRNA and miRNA have attracted a great deal of attention from researchers and clinicians. These molecules have been extensively…”
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Drug Resistance Driven by Cancer Stem Cells and Their Niche by Prieto-Vila, Marta, Takahashi, Ryou-U, Usuba, Wataru, Kohama, Isaku, Ochiya, Takahiro

“…Drug resistance represents one of the greatest challenges in cancer treatment. Cancer stem cells (CSCs), a subset of cells within the tumor with the potential…”
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Targeting DNA binding proteins for cancer therapy by Shiroma, Yoshitomo, Takahashi, Ryou‐u, Yamamoto, Yuki, Tahara, Hidetoshi

“…Dysregulation or mutation of DNA binding proteins such as transcription factors (TFs) is associated with the onset and progression of various types of disease,…”
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Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts by Naito, Yutaka, Yamamoto, Yusuke, Sakamoto, Naoya, Shimomura, Iwao, Kogure, Akiko, Kumazaki, Minami, Yokoi, Akira, Yashiro, Masakazu, Kiyono, Tohru, Yanagihara, Kazuyoshi, Takahashi, Ryou-u, Hirakawa, Kosei, Yasui, Wataru, Ochiya, Takahiro

“…Cancer-associated fibroblasts (CAFs), one of the major components of a tumour microenvironment, comprise heterogeneous populations involved in tumour…”
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The role of extracellular vesicle microRNAs in cancer biology by Takahashi, Ryou-U, Prieto-Vila, Marta, Hironaka, Ai, Ochiya, Takahiro

“…microRNAs (miRNAs) constitute a large family of small, approximately 20-22 nucleotide non-coding RNAs that regulate the expression of target genes, mainly at…”
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Predicting the presence of breast cancer using circulating small RNAs, including those in the extracellular vesicles by Koi, Yumiko, Tsutani, Yasuhiro, Nishiyama, Yukie, Ueda, Daisuke, Ibuki, Yuta, Sasada, Shinsuke, Akita, Tomoyuki, Masumoto, Norio, Kadoya, Takayuki, Yamamoto, Yuki, Takahashi, Ryou‐u, Tanaka, Junko, Okada, Morihito, Tahara, Hidetoshi

“…Emerging evidence indicates that small RNAs, including microRNAs (miRNAs) and their isoforms (isomiRs), and transfer RNA fragments (tRFs), are differently…”
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The Roles of MicroRNAs in Breast Cancer by Takahashi, Ryou-U, Miyazaki, Hiroaki, Ochiya, Takahiro

“…MicroRNAs (miRNAs) constitute a large family of small, approximately 20-22 nucleotide, non-coding RNAs that regulate the expression of target genes, mainly at…”
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miR‐148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells by Gailhouste, Luc, Gomez‐Santos, Laura, Hagiwara, Keitaro, Hatada, Izuho, Kitagawa, Noriyuki, Kawaharada, Kazushi, Thirion, Muriel, Kosaka, Nobuyoshi, Takahashi, Ryou‐u, Shibata, Tatsuhiro, Miyajima, Atsushi, Ochiya, Takahiro

“…MicroRNAs (miRNAs) are evolutionary conserved small RNAs that post‐transcriptionally regulate the expression of target genes. To date, the role of miRNAs in…”
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Single-Cell Analysis Reveals a Preexisting Drug-Resistant Subpopulation in the Luminal Breast Cancer Subtype by Prieto-Vila, Marta, Usuba, Wataru, Takahashi, Ryou-U, Shimomura, Iwao, Sasaki, Hideo, Ochiya, Takahiro, Yamamoto, Yusuke

“…Drug resistance is a major obstacle in the treatment of breast cancer. Surviving cells lead to tumor recurrence and metastasis, which remains the main cause of…”
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Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1 by Takahashi, Ryou-u, Miyazaki, Hiroaki, Takeshita, Fumitaka, Yamamoto, Yusuke, Minoura, Kaho, Ono, Makiko, Kodaira, Makoto, Tamura, Kenji, Mori, Masaki, Ochiya, Takahiro

“…Cancer stem cells (CSCs) have been identified in various types of cancer; however, the mechanisms by which cells acquire CSC properties such as drug resistance…”
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miR-22 represses cancer progression by inducing cellular senescence by Xu, Dan, Takeshita, Fumitaka, Hino, Yumiko, Fukunaga, Saori, Kudo, Yasusei, Tamaki, Aya, Matsunaga, Junko, Takahashi, Ryou-U, Takata, Takashi, Shimamoto, Akira, Ochiya, Takahiro, Tahara, Hidetoshi

“…Cellular senescence acts as a barrier to cancer progression, and microRNAs (miRNAs) are thought to be potential senescence regulators. However, whether…”
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Systemic Delivery of Synthetic MicroRNA-16 Inhibits the Growth of Metastatic Prostate Tumors via Downregulation of Multiple Cell-cycle Genes by Takeshita, Fumitaka, Patrawala, Lubna, Osaki, Mitsuhiko, Takahashi, Ryou-u, Yamamoto, Yusuke, Kosaka, Nobuyoshi, Kawamata, Masaki, Kelnar, Kevin, Bader, Andreas G., Brown, David, Ochiya, Takahiro

“…Recent reports have linked the expression of specific microRNAs (miRNAs) with tumorigenesis and metastasis. Here, we show that microRNA (miR)-16, which is…”
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Quercetin Inhibits Lef1 and Resensitizes Docetaxel-Resistant Breast Cancer Cells by Prieto-Vila, Marta, Shimomura, Iwao, Kogure, Akiko, Usuba, Wataru, Takahashi, Ryou-U, Ochiya, Takahiro, Yamamoto, Yusuke

“…Drug resistance is a major problem for breast cancer patients. Docetaxel is an anti-mitotic agent that serves as first line of treatment in metastatic breast…”
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Clinical Relevance and Therapeutic Significance of MicroRNA‐133a Expression Profiles and Functions in Malignant Osteosarcoma‐Initiating Cells by Fujiwara, Tomohiro, Katsuda, Takeshi, Hagiwara, Keitaro, Kosaka, Nobuyoshi, Yoshioka, Yusuke, Takahashi, Ryou‐U, Takeshita, Fumitaka, Kubota, Daisuke, Kondo, Tadashi, Ichikawa, Hitoshi, Yoshida, Akihiko, Kobayashi, Eisuke, Kawai, Akira, Ozaki, Toshifumi, Ochiya, Takahiro

“…Novel strategies against treatment‐resistant tumor cells remain a challenging but promising therapeutic approach. Despite accumulated evidence suggesting the…”
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Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer by Koi, Yumiko, Tsutani, Yasuhiro, Nishiyama, Yukie, Kanda, Miyuki, Shiroma, Yoshitomo, Yamamoto, Yuki, Sasada, Shinsuke, Akita, Tomoyuki, Masumoto, Norio, Kadoya, Takayuki, Takahashi, Ryou‐u, Tanaka, Junko, Okada, Morihito, Tahara, Hidetoshi

“…The telomere G‐tail (G‐tail) plays an essential role in maintaining chromosome stability. In this study, we assessed the leukocyte G‐tail length of breast…”
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The role of microRNAs in the regulation of cancer stem cells by Takahashi, Ryou-U, Miyazaki, Hiroaki, Ochiya, Takahiro

“…Cancer stem cells (CSCs) have been reported in many human tumors and are proposed to drive tumor initiation and progression. CSCs share a variety of biological…”
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A tissue microRNA signature that predicts the prognosis of breast cancer in young women by Hironaka-Mitsuhashi, Ai, Matsuzaki, Juntaro, Takahashi, Ryou-U, Yoshida, Masayuki, Nezu, Yutaka, Yamamoto, Yusuke, Shiino, Sho, Kinoshita, Takayuki, Ushijima, Toshikazu, Hiraoka, Nobuyoshi, Shimizu, Chikako, Tamura, Kenji, Ochiya, Takahiro

“…Since breast cancers in young women are generally aggressive, young patients tend to be intensively treated with anti-cancer drugs. To optimize the strategy…”
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Therapeutic Effects of MicroRNA-582-5p and -3p on the Inhibition of Bladder Cancer Progression by Uchino, Keita, Takeshita, Fumitaka, Takahashi, Ryou-u, Kosaka, Nobuyoshi, Fujiwara, Kae, Naruoka, Haruna, Sonoke, Satoru, Yano, Junichi, Sasaki, Hideo, Nozawa, Shiari, Yoshiike, Miki, Kitajima, Kazuki, Chikaraishi, Tatsuya, Ochiya, Takahiro

“…Many reports have indicated that the abnormal expression of microRNAs (miRNAs) is associated with the progression of disease and have identified miRNAs as…”
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An integrative genomic analysis revealed the relevance of microRNA and gene expression for drug-resistance in human breast cancer cells by Yamamoto, Yusuke, Yoshioka, Yusuke, Minoura, Kaho, Takahashi, Ryou-u, Takeshita, Fumitaka, Taya, Toshiki, Horii, Reiko, Fukuoka, Yayoi, Kato, Takashi, Kosaka, Nobuyoshi, Ochiya, Takahiro

“…Acquisition of drug-resistance in cancer has led to treatment failure, however, their mechanisms have not been clarified yet. Recent observations indicated…”
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Bacterial SOS Genes mucAB/umuDC Promote Mouse Tumors by Activating Oncogenes Nedd9/Aurkb via a miR-145 Sponge by Tanooka, Hiroshi, Inoue, Ayako, Takahashi, Ryou-U, Tatsumi, Kouichi, Fujikawa, Kazuo, Nagao, Tetsuji, Ishiai, Masamichi, Chiwaki, Fumiko, Aoyagi, Kazuhiko, Sasaki, Hiroki, Ochiya, Takahiro

“…The mechanism of cancer induction involves an aberrant expression of oncogenes whose functions can be controlled by RNAi with miRNA. Even foreign bacterial RNA…”
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