Search Results - "Takahashi, Reinaldo N"

Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials by Bitencourt, Rafael M, Takahashi, Reinaldo N

“…Post-traumatic stress disorder (PTSD) is characterized by poor adaptation to a traumatic experience. This disorder affects approximately 10% of people at some…”
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Anti-inflammatory lipoxin A₄ is an endogenous allosteric enhancer of CB₁ cannabinoid receptor by Pamplona, Fabricio A, Ferreira, Juliano, Menezes de Lima, Octávio, Duarte, Filipe Silveira, Bento, Allisson Freire, Forner, Stefânia, Villarinho, Jardel G, Bellochio, Luigi, Wotjak, Carsten T, Lerner, Raissa, Monory, Krisztina, Lutz, Beat, Canetti, Claudio, Matias, Isabelle, Calixto, João Batista, Marsicano, Giovanni, Guimarães, Marilia Z. P, Takahashi, Reinaldo N

“…Allosteric modulation of G-protein–coupled receptors represents a key goal of current pharmacology. In particular, endogenous allosteric modulators might…”
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Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats by Bitencourt, Rafael M, Pamplona, Fabrício A, Takahashi, Reinaldo N

“…Abstract The present study investigated the central effects of the eCB uptake/metabolism inhibitor AM404 and the phytocannabinoid cannabidiol (CBD) on the…”
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From an Alternative Medicine to a New Treatment for Refractory Epilepsies: Can Cannabidiol Follow the Same Path to Treat Neuropsychiatric Disorders? by Bitencourt, Rafael M, Takahashi, Reinaldo N, Carlini, Elisaldo A

“…Although cannabis has been known for ages as an "alternative medicine" to provide relief from seizures, pain, anxiety, and inflammation, there had always been…”
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Early signs of colonic inflammation, intestinal dysfunction, and olfactory impairments in the rotenone-induced mouse model of Parkinson’s disease by Morais, Lívia H, Hara, Daniela B, Bicca, Maíra A, Poli, Anicleto, Takahashi, Reinaldo N

“…The factors that trigger the pathophysiology of Parkinson’s disease (PD) are unknown. However, it is suggested that environmental factors, such as exposure to…”
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The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats by Pamplona, Fabrício A, Prediger, Rui D S, Pandolfo, Pablo, Takahashi, Reinaldo N

“…Previous studies demonstrated that pharmacological blockade of CB1 cannabinoid receptors decreases the extinction of conditioned fear and spatial memory in…”
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Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum by Pandolfo, Pablo, Silveirinha, Vasco, Santos-Rodrigues, Alexandre dos, Venance, Laurent, Ledent, Catherine, Takahashi, Reinaldo N., Cunha, Rodrigo A., Köfalvi, Attila

“…Adenosine, dopamine and endocannabinoids strictly modulate the release of one another in the dorsolateral striatum thereby controlling synaptic plasticity. As…”
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Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat–an animal model of attention deficit hyperactivity disorder by Pandolfo, Pablo, Vendruscolo, Leandro F., Sordi, Regina, Takahashi, Reinaldo N.

“…Rationale Cannabis preparations are the most widely consumed illicit drugs, and their use typically begins in adolescence. The prevalence of cannabis abuse is…”
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Short- and long-term effects of cannabinoids on the extinction of contextual fear memory in rats by Pamplona, Fabrício A., Bitencourt, Rafael M., Takahashi, Reinaldo N.

“…Facilitation of memory extinction by manipulation of the endocannabinoid (eCB) system has been recently studied in several paradigms. Our previous results…”
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Angiotensin II type 1/adenosine A 2A receptor oligomers: a novel target for tardive dyskinesia by Oliveira, Paulo A de, Dalton, James A R, López-Cano, Marc, Ricarte, Adrià, Morató, Xavier, Matheus, Filipe C, Cunha, Andréia S, Müller, Christa E, Takahashi, Reinaldo N, Fernández-Dueñas, Víctor, Giraldo, Jesús, Prediger, Rui D, Ciruela, Francisco

“…Tardive dyskinesia (TD) is a serious motor side effect that may appear after long-term treatment with neuroleptics and mostly mediated by dopamine D receptors…”
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Modulation of short-term social memory in rats by adenosine A1 and A2A receptors by PREDIGER, Rui D. S, TAKAHASHI, Reinaldo N

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Chronic caffeine treatment during prepubertal period confers long-term cognitive benefits in adult spontaneously hypertensive rats (SHR), an animal model of attention deficit hyperactivity disorder (ADHD) by Pires, Vanessa A., Pamplona, Fabrício A., Pandolfo, Pablo, Prediger, Rui D.S., Takahashi, Reinaldo N.

“…▶ Methilphenydate validates SHR as an animal model of ADHD. ▶ Prepubertal period is critical for cognitive deficits of SHR. ▶ Chronic caffeine improves…”
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Activation of adenosine A1 receptors reduces anxiety-like behavior during acute ethanol withdrawal (hangover) in mice by Prediger, Rui D S, da Silva, George E, Batista, Luciano C, Bittencourt, Alvorita L, Takahashi, Reinaldo N

“…Elevated signs of anxiety are observed in both humans and rodents during withdrawal from chronic as well as acute ethanol exposure, and it represents an…”
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Interactions of Noradrenergic, Glucocorticoid and Endocannabinoid Systems Intensify and Generalize Fear Memory Traces by Gazarini, Lucas, Stern, Cristina A., Takahashi, Reinaldo N., Bertoglio, Leandro J.

“…[Display omitted] •High dose of adrenaline, corticosterone, or AM251 potentiated fear memory intensity.•Combining a low dose of adrenaline with corticosterone…”
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Increased sensitivity of adolescent spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder, to the locomotor stimulation induced by the cannabinoid receptor agonist WIN 55,212-2 by Pandolfo, Pablo, Pamplona, Fabrício A., Prediger, Rui D.S., Takahashi, Reinaldo N.

“…Converging evidence points to adolescence as a critical period for the onset of a wide range of neuropsychiatric disorders, including attention deficit…”
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On Disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment by STERN, Cristina Aj, GAZARINI, Lucas, TAKAHASHI, Reinaldo N, GUIMARAES, Francisco S, BERTOGLIO, Leandro J

“…The search for reconsolidation blockers may uncover clinically relevant drugs for disrupting memories of significant stressful life experiences, such as those…”
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Cannabidiol disrupts the consolidation of specific and generalized fear memories via dorsal hippocampus CB1 and CB2 receptors by Stern, Cristina A.J., da Silva, Thiago R., Raymundi, Ana M., de Souza, Camila P., Hiroaki-Sato, Vinicius A., Kato, Luiza, Guimarães, Francisco S., Andreatini, Roberto, Takahashi, Reinaldo N., Bertoglio, Leandro J.

“…Pharmacological interventions able to modulate a fear memory while it is consolidated could have therapeutic value in tempering those maladaptively…”
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Effects of Cannabinoid Drugs on Aversive or Rewarding Drug-Associated Memory Extinction and Reconsolidation by Stern, Cristina A.J., de Carvalho, Cristiane R., Bertoglio, Leandro J., Takahashi, Reinaldo N.

“…[Display omitted] •Activation of CB1 receptors during extinction or reconsolidation attenuates emotional memories.•Antagonism of CB1 receptors attenuates the…”
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Blockade of adenosine and dopamine receptors inhibits the development of rapid tolerance to ethanol in mice by BATISTA, Luciano C, PREDIGER, Rui D. S, MORATO, Gina S, TAKAHASHI, Reinaldo N

“…Several reports have suggested the involvement of brain adenosine and dopamine receptors in different actions produced by ethanol such as motor incoordination…”
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Infusion of cannabidiol into infralimbic cortex facilitates fear extinction via CB1 receptors by Do Monte, Fabricio H., Souza, Rimenez R., Bitencourt, Rafael M., Kroon, Juliana A., Takahashi, Reinaldo N.

“…•Intra-IL infusion of cannabidiol facilitates extinction of contextual fear.•Rimonabant blocks the facilitating effect of intra-IL cannabidiol on fear…”
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