Search Results - "Takahashi, Nobuhiko"

Lupus anticoagulant-hypoprothrombinemia syndrome and similar diseases: experiences at a single center in Japan by Ieko, Masahiro, Yoshida, Mika, Naito, Sumiyoshi, Ohmura, Kazumasa, Takahashi, Nobuhiko

“…Patients with lupus anticoagulant (LA), a thrombotic risk factor, along with decreased prothrombin (FII) activity are classified as lupus…”
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Knockdown of long noncoding RNA dreh facilitates cell surface GLUT4 expression and glucose uptake through the involvement of vimentin in 3T3-L1 adipocytes by Takahashi, Nobuhiko, Kimura, Atsushi P., Ohmura, Kazumasa, Naito, Sumiyoshi, Yoshida, Mika, Ieko, Masahiro

“…•Long noncoding RNA Dreh is expressed in 3T3-L1 fibroblasts and adipocytes.•Knockdown of lncRNA Dreh facilitates glucose uptake in 3T3-L1 adipocytes.•Dreh…”
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Dreh, a long noncoding RNA repressed by metformin, regulates glucose transport in C2C12 skeletal muscle cells by Takahashi, Nobuhiko, Kimura, Atsushi P., Otsuka, Kai, Ohmura, Kazumasa, Naito, Sumiyoshi, Yoshida, Mika, Ieko, Masahiro

“…The anti-hyperglycemic action of metformin on skeletal muscles is presently unclear. Long noncoding RNAs (lncRNAs) are implicated in multiple cellular…”
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Novel assay based on diluted prothrombin time reflects anticoagulant effects of direct oral factor Xa inhibitors: Results of multicenter study in Japan by Ieko, Masahiro, Ohmura, Kazumasa, Naito, Sumiyoshi, Yoshida, Mika, Sakuma, Ichiro, Ikeda, Kozue, Ono, Shouko, Suzuki, Takeshi, Takahashi, Nobuhiko

“…Direct oral anticoagulants targeting factor Xa (DXaIs) are administered as prophylaxis for various venothrombotic diseases without routine monitoring required…”
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Profiles of direct oral anticoagulants and clinical usage-dosage and dose regimen differences by Ieko, Masahiro, Naitoh, Sumiyoshi, Yoshida, Mika, Takahashi, Nobuhiko

“…The availability of direct oral anticoagulants (DOACs) has caused a paradigm shift in thrombosis management. DOAC profiles do not differ greatly, though they…”
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Lupus anticoagulant-hypoproaccelerin (factor V) syndrome (LAHPS-V): a new hemorrhagic condition associated with lupus anticoagulant by Ieko, Masahiro, Naito, Sumiyoshi, Yoshida, Mika, Ohmura, Kazumasa, Takahashi, Nobuhiko, Sugawara, Norifumi, Kiyohara, Kazuki, Shimosegawa, Kenji, Ichinose, Akitada

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Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues by Tamura, Hirosumi, Higa, Arisa, Hoshi, Hirotaka, Hiyama, Gen, Takahashi, Nobuhiko, Ryufuku, Masae, Morisawa, Gaku, Yanagisawa, Yuka, Ito, Emi, Imai, Jun-Ichi, Dobashi, Yuu, Katahira, Kiyoaki, Soeda, Shu, Watanabe, Takafumi, Fujimori, Keiya, Watanabe, Shinya, Takagi, Motoki

“…Patient-derived tumor xenograft models represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture;…”
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Adiponectin acts in the brain to decrease body weight by Ahima, Rexford S, Qi, Yong, Takahashi, Nobuhiko, Hileman, Stanley M, Patel, Hiralben R, Berg, Anders H, Pajvani, Utpal B, Scherer, Philipp E

“…Adiponectin (ADP) is an adipocyte hormone involved in glucose and lipid metabolism. We detected a rise in ADP in cerebrospinal fluid after intravenous (i.v.)…”
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Measurement of coagulation factor antibody levels is useful for diagnosis and determining therapeutic efficacy in hemorrhagic patients with autoantibodies to coagulation factor VIII and factor V: results from a single center in Japan by Ieko, Masahiro, Ohmura, Kazumasa, Naito, Sumiyoshi, Yoshida, Mika, Saito, Makoto, Kiyohara, Kazuki, Miyazima, Shinri, Maeta, Takahiro, Ohtsu, Akihiro, Shimosegawa, Kenji, Takahashi, Nobuhiko, Ichinose, Akitada

“…Coagulation factor inhibitors (CFIs) sometimes cause fatal bleeding conditions. Determination of an inhibitor titer (INH-titer) using the Bethesda method is…”
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The antiphosphatidylserine/prothrombin detection in solid phase assay is largely dependent on the type of samples by Kumano, Osamu, Ieko, Masahiro, Yoshida, Mika, Naito, Sumiyoshi, Ohmura, Kazumasa, Takahashi, Nobuhiko

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An In Vitro System for Evaluating Molecular Targeted Drugs Using Lung Patient-Derived Tumor Organoids by Takahashi, Nobuhiko, Hoshi, Hirotaka, Higa, Arisa, Hiyama, Gen, Tamura, Hirosumi, Ogawa, Mayu, Takagi, Kosuke, Goda, Kazuhito, Okabe, Naoyuki, Muto, Satoshi, Suzuki, Hiroyuki, Shimomura, Kenju, Watanabe, Shinya, Takagi, Motoki

“…Patient-derived tumor organoids (PDOs) represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture…”
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Construction of in vitro patient-derived tumor models to evaluate anticancer agents and cancer immunotherapy by Takahashi, Nobuhiko, Higa, Arisa, Hiyama, Gen, Tamura, Hirosumi, Hoshi, Hirotaka, Dobashi, Yuu, Katahira, Kiyoaki, Ishihara, Hiroya, Takagi, Kosuke, Goda, Kazuhito, Okabe, Naoyuki, Muto, Satoshi, Suzuki, Hiroyuki, Shimomura, Kenju, Watanabe, Shinya, Takagi, Motoki

“…An assay system using patient-derived tumor models represents a promising preclinical cancer model that replicates the disease better than traditional cell…”
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Considerations for simultaneous detection of autoantibodies to coagulation factor and lupus anticoagulant by Ieko, Masahiro, Ohmura, Kazumasa, Naito, Sumiyoshi, Yoshida, Mika, Sasaki, Hisaomi, Sato, Tsuyoshi, Sugawara, Norifumi, Takahashi, Nobuhiko, Ichinose, Akitada

“…In patients with autoimmune coagulation factor deficiency (AiCFD), the production of autoantibodies that inhibit coagulation factors in the blood reduces the…”
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Comparative evaluation of reagents for measuring protein S activity: possibility of harmonization by Ieko, Masahiro, Hotta, Taeko, Watanabe, Kumiko, Adachi, Tomoko, Takeuchi, Sawako, Naito, Sumiyoshi, Yoshida, Mika, Ohmura, Kazumasa, Takahashi, Nobuhiko, Morishita, Eriko, Tsuda, Hiroko, Kang, Dongchon

“…Patients with congenital protein S (PS) deficiency show a hereditary predisposition for thrombosis, and PS deficiency is prevalent among Japanese populations…”
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Regulation of Resistin Expression and Circulating Levels in Obesity, Diabetes, and Fasting by Rajala, Michael W, Qi, Yong, Patel, Hiral R, Takahashi, Nobuhiko, Banerjee, Ronadip, Pajvani, Utpal B, Sinha, Madhur K, Gingerich, Ronald L, Scherer, Philipp E, Ahima, Rexford S

“…Regulation of Resistin Expression and Circulating Levels in Obesity, Diabetes, and Fasting Michael W. Rajala 1 , Yong Qi 2 , Hiral R. Patel 2 , Nobuhiko…”
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Verification of the guidelines for lupus anticoagulant detection: Usefulness of index for circulating anticoagulant in APTT mixing test by Kumano, Osamu, Ieko, Masahiro, Naito, Sumiyoshi, Yoshida, Mika, Takahashi, Nobuhiko, Suzuki, Takeshi, Aoki, Takashi

“…Abstract Introduction Lupus anticoagulant (LA) is an antibody that interferes with one or more in vitro coagulation reactions, which are dependent on…”
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Construction of a novel cell-based assay for the evaluation of anti-EGFR drug efficacy against EGFR mutation by Hoshi, Hirotaka, Hiyama, Gen, Ishikawa, Kosuke, Inageda, Kiyoshi, Fujimoto, Jiro, Wakamatsu, Ai, Togashi, Takushi, Kawamura, Yoshifumi, Takahashi, Nobuhiko, Higa, Arisa, Goshima, Naoki, Semba, Kentaro, Watanabe, Shinya, Takagi, Motoki

“…Epidermal growth factor receptor (EGFR) overexpression and EGFR-mediated signaling pathway dysregulation have been observed in tumors from patients with…”
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Lipopolysaccharide induces adipose differentiation-related protein expression and lipid accumulation in the liver through inhibition of fatty acid oxidation in mice by Ohhira, Masumi, Motomura, Wataru, Fukuda, Mitsuko, Yoshizaki, Takayuki, Takahashi, Nobuhiko, Tanno, Satoshi, Wakamiya, Nobutaka, Kohgo, Yutaka, Kumei, Shima, Okumura, Toshikatsu

“…In the present study, we examined the effect of lipopolysaccharide (LPS) on liver histopathology with special reference to lipid metabolism in mice. Mice were…”
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Sarcolipin expression is repressed by endoplasmic reticulum stress in C2C12 myotubes by Takahashi, Nobuhiko, Kimura, Atsushi P., Naito, Sumiyoshi, Yoshida, Mika, Kumano, Osamu, Suzuki, Takeshi, Itaya, Satoshi, Moriya, Mitsuru, Tsuji, Masahiro, Ieko, Masahiro

“…Sarcolipin is a transmembrane protein expressed in the sarco/endoplasmic reticulum of skeletal and atrial muscles in large animals. Sarcolipin plays crucial…”
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PPARγ ligand‐induced apoptosis through a p53‐dependent mechanism in human gastric cancer cells by Nagamine, Miho, Okumura, Toshikatsu, Tanno, Satoshi, Sawamukai, Mitsuko, Motomura, Wataru, Takahashi, Nobuhiko, Kongo, Yutaka

“…We have recently demonstrated that the PPARγ ligand troglitazone induced cell growth arrest and evoked apoptosis in a gastric cancer cell line, MKN–45. Since…”
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