Search Results - "Takahashi, J S"

Molecular components of the circadian clock in mammals by Takahashi, J. S.

“…The circadian clock mechanism in animals involves a transcriptional feedback loop in which the bHLH‐PAS proteins CLOCK and BMAL1 form a transcriptional…”
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Re: Suppressed Recurrent Bladder Cancer after Androgen Suppression with Androgen Deprivation Therapy or 5α-Reductase Inhibitor: M. Shiota, K. Kiyoshima, A. Yokomizo, A. Takeuchi, E. Kashiwagi, T. Dejima, R. Takahashi, J. Inokuchi, K. Tatsugami and M. Eto J Urol 2017;197:308-313 by Kim, Jae Heon, Chung, Benjamin I

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Molecular genetics of circadian rhythms in mammals by KING, D. P, TAKAHASHI, J. S

“…Recent gene discovery approaches have led to a new era in our understanding of the molecular basis of circadian oscillators in animals. A conserved set of…”
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Supplement to “Normal del Pezzo surfaces of rank one with log canonical singularities” by H. Kojima and T. Takahashi [J. Algebra 360 (2012) 53–70] by Kojima, Hideo

“…Kojima and Takahashi (2012) [5] proved that every normal del Pezzo surface of rank one with only rational log canonical singular points has at most five…”
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Role of the CLOCK Protein in the Mammalian Circadian Mechanism by Gekakis, Nicholas, Staknis, David, Nguyen, Hubert B., Davis, Fred C., Wilsbacher, Lisa D., King, David P., Takahashi, Joseph S., Weitz, Charles J.

“…The mouse Clock gene encodes a bHLH-PAS protein that regulates circadian rhythms and is related to transcription factors that act as heterodimers. Potential…”
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A CLOCK polymorphism associated with human diurnal preference by KATZENBERG, D, YOUNG, T, FINN, L, LING LIN, KING, D. P, TAKAHASHI, J. S, MIGNOT, E

“…A single nucleotide polymorphism located in the 3' flanking region of the human CLOCK gene was investigated as a predictor of diurnal preference in a…”
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Stopping time : The genetics of fly and mouse circadian clocks by ALLADA, Ravi, EMERY, Patrick, TAKAHASHI, Joseph S, ROSBASH, Michael

“…Forward genetic analyses in flies and mice have uncovered conserved transcriptional feedback loops at the heart of circadian pacemakers. Conserved mechanisms…”
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The Circadian Clock Mutation Alters Sleep Homeostasis in the Mouse by Naylor, Erik, Bergmann, Bernard M, Krauski, Kristyn, Zee, Phyllis C, Takahashi, Joseph S, Vitaterna, Martha Hotz, Turek, Fred W

“…The onset and duration of sleep are thought to be primarily under the control of a homeostatic mechanism affected by previous periods of wake and sleep and a…”
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Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim by Darlington, Thomas K., Wager-Smith, Karen, Ceriani, M. Fernanda, Staknis, David, Gekakis, Nicholas, Thomas D. L. Steeves, Weitz, Charles J., Takahashi, Joseph S., Kay, Steve A.

“…The circadian oscillator generates a rhythmic output with a period of about 24 hours. Despite extensive studies in several model systems, the biochemical mode…”
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GENETICS OF THE MAMMALIAN CIRCADIAN SYSTEM: Photic Entrainment, Circadian Pacemaker Mechanisms, and Posttranslational Regulation by Lowrey, Phillip L, Takahashi, Joseph S

“…During the past four years, significant progress has been made in identifying the molecular components of the mammalian circadian clock system. An…”
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Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses by Thresher, Randy J., Vitaterna, Martha Hotz, Miyamoto, Yasuhide, Kazantsev, Aleksey, Hsu, David S., Petit, Claude, Selby, Christopher P., Dawut, Lale, Smithies, Oliver, Takahashi, Joseph S., Sancar, Aziz

“…Cryptochromes are photoactive pigments in the eye that have been proposed to function as circadian photopigments. Mice lacking the cryptochrome 2 blue-light…”
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Sensitivity and integration in a visual pathway for circadian entrainment in the hamster (Mesocricetus auratus) by Nelson, D E, Takahashi, J S

“…1. Light-induced phase shifts of the circadian rhythm of wheel-running activity were used to measure the photic sensitivity of a circadian pacemaker and the…”
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Mutagenesis and Mapping of a Mouse Gene, Clock, Essential for Circadian Behavior by Vitaterna, Martha Hotz, King, David P., Chang, Anne-Marie, Kornhauser, Jon M., Lowrey, Phillip L., McDonald, J. David, Dove, William F., Pinto, Lawrence H., Turek, Fred W., Takahashi, Joseph S.

“…In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU) were screened for circadian…”
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Sequence interpretation. Functional annotation of mouse genome sequences by Nadeau, J H, Balling, R, Barsh, G, Beier, D, Brown, S D, Bucan, M, Camper, S, Carlson, G, Copeland, N, Eppig, J, Fletcher, C, Frankel, W N, Ganten, D, Goldowitz, D, Goodnow, C, Guenet, J L, Hicks, G, Hrabe de Angelis, M, Jackson, I, Jacob, H J, Jenkins, N, Johnson, D, Justice, M, Kay, S, Kingsley, D, Lehrach, H, Magnuson, T, Meisler, M, Poustka, A, Rinchik, E M, Rossant, J, Russell, L B, Schimenti, J, Shiroishi, T, Skarnes, W C, Soriano, P, Stanford, W, Takahashi, J S, Wurst, W, Zimmer, A

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Effects of aging on light-induced phase-shifting of circadian behavioral rhythms, Fos expression and creb phosphorylation in the hamster suprachiasmatic nucleus by Zhang, Y., Kornhauser, J.M., Zee, P.C., Mayo, K.E., Takahashi, J.S., Turek, F.W.

“…Aging is associated with a variety of alterations in circadian rhythms, including changes in the response to environmental stimuli. The underlying causes for…”
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The Basic Helix-Loop-Helix-PAS Protein MOP9 Is a Brain-Specific Heterodimeric Partner of Circadian and Hypoxia Factors by Hogenesch, John B, Gu, Yi-Zhong, Moran, Susan M, Shimomura, Kazuhiro, Radcliffe, Laurel A, Takahashi, Joseph S, Bradfield, Christopher A

“…PAS (PER, ARNT, SIM) proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants,…”
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Depressive-like behavior and stress reactivity are independent traits in a Wistar Kyoto x Fisher 344 cross by Solberg, L C, Ahmadiyeh, N, Baum, A E, Vitaterna, M H, Takahashi, J S, Turek, F W, Redei, E E

“…Depression is a heritable disorder that is often precipitated by stress. Abnormalities of the stress-reactive hypothalamic-pituitary-adrenal (HPA) axis are…”
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Mammalian circadian biology: elucidating genome-wide levels of temporal organization by Lowrey, Phillip L, Takahashi, Joseph S

“…During the past decade, the molecular mechanisms underlying the mammalian circadian clock have been defined. A core set of circadian clock genes common to most…”
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Molecular cloning and characterization of the human CLOCK gene : Expression in the suprachiasmatic nuclei by STEEVES, T. D. L, KING, D. P, YALIANG ZHAO, SANGORAM, A. M, FENGHE DU, BOWCOCK, A. M, MOORE, R. Y, TAKAHASHI, J. S

“…The Clock gene is an essential regulator of circadian rhythms. It encodes a member of the basic helix-loop-helix/PER-ARNT-SIM family of transcription factors…”
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Forward and Reverse Genetic Approaches to Behavior in the Mouse by Takahashi, Joseph S., Pinto, Lawrence H., Vitaterna, Martha Hotz

“…Modern molecular genetic and genomic approaches are revolutionizing the study of behavior in the mouse. "Reverse genetics" (from gene to phenotype) with…”
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