Search Results - "Takahashi, Akiko"

Cellular senescence and senescence‐associated secretory phenotype via the cGAS‐STING signaling pathway in cancer by Loo, Tze Mun, Miyata, Kenichi, Tanaka, Yoko, Takahashi, Akiko

“…Cellular senescence is historically regarded as a tumor suppression mechanism to prevent damaged cells from aberrant proliferation in benign and premalignant…”
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Senescence-associated extracellular vesicle release plays a role in senescence-associated secretory phenotype (SASP) in age-associated diseases by Tanaka, Yoko, Takahashi, Akiko

“…Abstract Cellular senescence is an important tumour suppression mechanism that inhibits the proliferation of damaged cells. In senescent cells, irreparable DNA…”
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Evolution of the Hypothalamic-Pituitary-Gonadal Axis Regulation in Vertebrates Revealed by Knockout Medaka by Takahashi, Akiko, Kanda, Shinji, Abe, Tomohiro, Oka, Yoshitaka

“…Reproduction is essential for life, but its regulatory mechanism is diverse. The analysis of this diversity should lead us to understand the evolutionary…”
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Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 by Takasugi, Masaki, Okada, Ryo, Takahashi, Akiko, Virya Chen, David, Watanabe, Sugiko, Hara, Eiji

“…Cellular senescence prevents the proliferation of cells at risk for neoplastic transformation. However, the altered secretome of senescent cells can promote…”
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Exosomes maintain cellular homeostasis by excreting harmful DNA from cells by Takahashi, Akiko, Okada, Ryo, Nagao, Koji, Kawamata, Yuka, Hanyu, Aki, Yoshimoto, Shin, Takasugi, Masaki, Watanabe, Sugiko, Kanemaki, Masato T, Obuse, Chikashi, Hara, Eiji

“…Emerging evidence is revealing that exosomes contribute to many aspects of physiology and disease through intercellular communication. However, the biological…”
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Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells by Takahashi, Akiko, Loo, Tze Mun, Okada, Ryo, Kamachi, Fumitaka, Watanabe, Yoshihiro, Wakita, Masahiro, Watanabe, Sugiko, Kawamoto, Shimpei, Miyata, Kenichi, Barber, Glen N., Ohtani, Naoko, Hara, Eiji

“…Accumulating evidence indicates that the senescence-associated secretory phenotype (SASP) contributes to many aspects of physiology and disease. Thus,…”
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A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells by Wakita, Masahiro, Takahashi, Akiko, Sano, Osamu, Loo, Tze Mun, Imai, Yoshinori, Narukawa, Megumi, Iwata, Hidehisa, Matsudaira, Tatsuyuki, Kawamoto, Shimpei, Ohtani, Naoko, Yoshimori, Tamotsu, Hara, Eiji

“…Although cellular senescence acts primarily as a tumour suppression mechanism, the accumulation of senescent cells in vivo eventually exerts deleterious side…”
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Biology of extracellular vesicles secreted from senescent cells as senescence‐associated secretory phenotype factors by Misawa, Tomoka, Tanaka, Yoko, Okada, Ryo, Takahashi, Akiko

“…The increase of the morbidity rate in age‐related diseases, such as cancer, Alzheimer’s disease, arteriosclerosis and pulmonary fibrosis, has become a profound…”
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Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression by Miyata, Kenichi, Takahashi, Akiko

“…Cellular senescence provokes a dramatic alteration of chromatin organization and gene expression profile of proinflammatory factors, thereby contributing to…”
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Evolutionally Conserved Function of Kisspeptin Neuronal System Is Nonreproductive Regulation as Revealed by Nonmammalian Study by Nakajo, Mikoto, Kanda, Shinji, Karigo, Tomomi, Takahashi, Akiko, Akazome, Yasuhisa, Uenoyama, Yoshihisa, Kobayashi, Makito, Oka, Yoshitaka

“…Abstract The kisspeptin neuronal system, which consists of a neuropeptide kisspeptin and its receptor Gpr54, is considered in mammals a key factor of…”
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A Scoring System to Stratify Curability after Endoscopic Submucosal Dissection for Early Gastric Cancer: "eCura system" by Hatta, Waku, Gotoda, Takuji, Oyama, Tsuneo, Kawata, Noboru, Takahashi, Akiko, Yoshifuku, Yoshikazu, Hoteya, Shu, Nakagawa, Masahiro, Hirano, Masaaki, Esaki, Mitsuru, Matsuda, Mitsuru, Ohnita, Ken, Yamanouchi, Kohei, Yoshida, Motoyuki, Dohi, Osamu, Takada, Jun, Tanaka, Keiko, Yamada, Shinya, Tsuji, Tsuyotoshi, Ito, Hirotaka, Hayashi, Yoshiaki, Nakaya, Naoki, Nakamura, Tomohiro, Shimosegawa, Tooru

“…Although radical surgery is recommended for patients not meeting the curative criteria for endoscopic submucosal dissection (ESD) of early gastric cancer (EGC)…”
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Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion by Okumura, Shintaro, Konishi, Yusuke, Narukawa, Megumi, Sugiura, Yuki, Yoshimoto, Shin, Arai, Yuriko, Sato, Shintaro, Yoshida, Yasuo, Tsuji, Shunya, Uemura, Ken, Wakita, Masahiro, Matsudaira, Tatsuyuki, Matsumoto, Tomonori, Kawamoto, Shimpei, Takahashi, Akiko, Itatani, Yoshiro, Miki, Hiroaki, Takamatsu, Manabu, Obama, Kazutaka, Takeuchi, Kengo, Suematsu, Makoto, Ohtani, Naoko, Fukunaga, Yosuke, Ueno, Masashi, Sakai, Yoshiharu, Nagayama, Satoshi, Hara, Eiji

“…Emerging evidence is revealing that alterations in gut microbiota are associated with colorectal cancer (CRC). However, very little is currently known about…”
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Endoscopic hand-suturing is feasible, safe, and may reduce bleeding risk after gastric endoscopic submucosal dissection: a multicenter pilot study (with video) by Goto, Osamu, Oyama, Tsuneo, Ono, Hiroyuki, Takahashi, Akiko, Fujishiro, Mitsuhiro, Saito, Yukata, Abe, Seiichiro, Kaise, Mitsuru, Iwakiri, Katsuhiko, Yahagi, Naohisa

“…Endoscopic hand-suturing (EHS) provides secure intraluminal mucosal closure and should decrease the risk of adverse events after gastric endoscopic submucosal…”
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DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses by Hitomi, Kazuhiro, Okada, Ryo, Loo, Tze Mun, Miyata, Kenichi, Nakamura, Asako J, Takahashi, Akiko

“…DNA damage, caused by various oncogenic stresses, can induce cell death or cellular senescence as an important tumor suppressor mechanism. Senescent cells…”
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Usefulness and Limitations of a Serum Screening System to Predict the Risk of Gastric Cancer by Kishino, Takaaki, Oyama, Tsuneo, Tomori, Akihisa, Takahashi, Akiko, Shinohara, Tomoaki

“…Objective The aim of the present study was to evaluate the effectiveness and limitations of a serum screening system for predicting the risk of gastric cancer…”
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Long-term outcomes of endoscopic resection and metachronous cancer after endoscopic resection for adenocarcinoma of the esophagogastric junction in Japan by Abe, Seiichiro, Ishihara, Ryu, Takahashi, Hiroaki, Ono, Hiroyuki, Fujisaki, Junko, Matsui, Akira, Takahashi, Akiko, Goda, Kenichi, Kawada, Kenro, Koike, Tomoyuki, Takeuchi, Manabu, Tsuji, Yosuke, Hirasawa, Dai, Oyama, Tsuneo

“…Endoscopic resection (ER) of superficial adenocarcinoma of the esophagogastric junction (AEGJ) has been shown to be safe and effective. However, long-term data…”
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Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination by Yasuda, Tadahito, Koiwa, Mayu, Yonemura, Atsuko, Miyake, Keisuke, Kariya, Ryusho, Kubota, Sho, Yokomizo-Nakano, Takako, Yasuda-Yoshihara, Noriko, Uchihara, Tomoyuki, Itoyama, Rumi, Bu, Luke, Fu, Lingfeng, Arima, Kota, Izumi, Daisuke, Iwagami, Shiro, Eto, Kojiro, Iwatsuki, Masaaki, Baba, Yoshifumi, Yoshida, Naoya, Ohguchi, Hiroto, Okada, Seiji, Matsusaki, Keisuke, Sashida, Goro, Takahashi, Akiko, Tan, Patrick, Baba, Hideo, Ishimoto, Takatsugu

“…In the tumor microenvironment, senescent non-malignant cells, including cancer-associated fibroblasts (CAFs), exhibit a secretory profile under stress…”
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YBX1 Regulates Satellite II RNA Loading into Small Extracellular Vesicles and Promotes the Senescent Phenotype by Chiba, Masatomo, Miyata, Kenichi, Okawa, Hikaru, Tanaka, Yoko, Ueda, Koji, Seimiya, Hiroyuki, Takahashi, Akiko

“…Senescent cells secrete inflammatory proteins and small extracellular vesicles (sEVs), collectively termed senescence-associated secretory phenotype (SASP),…”
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Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer by Miyata, Kenichi, Imai, Yoshinori, Satoshi Hori, Mika Nishio, Loo, Tze Mun, Okada, Ryo, Yang, Liying, Nakadai, Tomoyoshi, Maruyama, Reo, Fujii, Risa, Ueda, Koji, Jiang, Li, Zheng, Hao, Toyokuni, Shinya, Sakata, Toyonori, Shirahige, Katsuhiko, Kojima, Ryosuke, Nakayama, Mizuho, Oshima, Masanobu, Nagayama, Satoshi, Seimiya, Hiroyuki, Hirota, Toru, Saya, Hideyuki, Hara, Eiji, Takahashi, Akiko

“…Cellular senescence causes a dramatic alteration of chromatin organization and changes the gene expression profile of proinflammatory factors, thereby…”
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LEARNING CURVE FOR ENDOSCOPIC SUBMUCOSAL DISSECTION OF LARGE COLORECTAL TUMORS by Hotta, Kinichi, Oyama, Tsuneo, Shinohara, Tomoaki, Miyata, Yoshinori, Takahashi, Akiko, Kitamura, Yoko, Tomori, Akihisa

“…Background and Aim:  No studies have previously described the learning curve for colonic endoscopic submucosal dissection (ESD). The aim of the present study…”
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