Search Results - "Takagi, Akimitsu"

Possibility of breast cancer prevention: use of soy isoflavones and fermented soy beverage produced using probiotics by Takagi, Akimitsu, Kano, Mitsuyoshi, Kaga, Chiaki

“…The various beneficial effects of soybeans, which are rich in phytochemicals, have received much attention because of increasing health awareness. Soy milk…”
Get full text

Antitumor activity of a novel oral signal transducer and activator of transcription 3 inhibitor YHO‐1701 by Nishisaka, Fukiko, Taniguchi, Keisuke, Tsugane, Momomi, Hirata, Genya, Takagi, Akimitsu, Asakawa, Naoyuki, Kurita, Akinobu, Takahashi, Hiroyuki, Ogo, Naohisa, Shishido, Yoshiyuki, Asai, Akira

“…The signal transducer and activator of transcription 3 (STAT3) signaling pathway is a key mediator of cancer cell proliferation, survival and invasion…”
Get full text

Lactobacillus casei Shirota enhances the preventive efficacy of soymilk in chemically induced breast cancer by Kaga, Chiaki, Takagi, Akimitsu, Kano, Mitsuyoshi, Kado, Shoichi, Kato, Ikuo, Sakai, Masashi, Miyazaki, Kouji, Nanno, Masanobu, Ishikawa, Fumiyasu, Ohashi, Yasuo, Toi, Masakazu

“…Soy foods are known to be effective for breast cancer prevention. The habitual consumption of soy isoflavones in combination with the probiotic Lactobacillus…”
Get full text

Perifosine, a Bioavailable Alkylphospholipid Akt Inhibitor, Exhibits Antitumor Activity in Murine Models of Cancer Brain Metastasis Through Favorable Tumor Exposure by Taniguchi, Keisuke, Suzuki, Tomo, Okamura, Tomomi, Kurita, Akinobu, Nohara, Gou, Ishii, Satoru, Kado, Shoichi, Takagi, Akimitsu, Tsugane, Momomi, Shishido, Yoshiyuki

“…Metastatic brain tumors are regarded as the most advanced stage of certain types of cancer; however, chemotherapy has played a limited role in the treatment of…”
Get full text

Specific Conformational Change in Giant DNA Caused by Anticancer Tetrazolato-Bridged Dinuclear Platinum(II) Complexes: Middle-Length Alkyl Substituents Exhibit Minimum Effect by Komeda, Seiji, Yoneyama, Hiroki, Uemura, Masako, Muramatsu, Akira, Okamoto, Naoto, Konishi, Hiroaki, Takahashi, Hiroyuki, Takagi, Akimitsu, Fukuda, Wakao, Imanaka, Tadayuki, Kanbe, Toshio, Harusawa, Shinya, Yoshikawa, Yuko, Yoshikawa, Kenichi

“…Derivatives of the highly antitumor-active compound [{cis-Pt­(NH3)2}2­(μ-OH)­(μ-tetrazolato-N2,N3)]2+ (5-H-Y), which is a tetrazolato-bridged dinuclear…”
Get full text

Resminostat, a histone deacetylase inhibitor, circumvents tolerance to EGFR inhibitors in EGFR-mutated lung cancer cells with BIM deletion polymorphism by Arai, Sachiko, Takeuchi, Shinji, Fukuda, Koji, Tanimoto, Azusa, Nishiyama, Akihiro, Konishi, Hiroaki, Takagi, Akimitsu, Takahashi, Hiroyuki, Ong, S. Tiong, Yano, Seiji

“…Drug-tolerant cells are mediators of acquired resistance. BIM-intron2 deletion polymorphism (BIM-del) is one of the mechanisms underlying the resistance to…”
Get full text

Three-dimensional Cellular Spheroid Formation Provides Human Prostate Tumor Cells with Tissue-like Features by TAKAGI, Akimitsu, WATANABE, Masatoshi, ISHII, Yasuhisa, MORITA, Joji, HIROKAWA, Yoshifumi, MATSUZAKI, Takeshi, SHIRAISHI, Taizo

“…Background: Alterations in the cellular biological responses were examined in a series of LNCaP human prostate tumor cells growing under different conditions…”
Get full text

Oxaliplatin induces mitotic catastrophe and apoptosis in esophageal cancer cells by Ngan, Chew Yee, Yamamoto, Hirofumi, Takagi, Akimitsu, Fujie, Yujiro, Takemasa, Ichiro, Ikeda, Masataka, Takahashi‐Yanaga, Fumi, Sasaguri, Toshiyuki, Sekimoto, Mitsugu, Matsuura, Nariaki, Monden, Morito

“…The platinum‐based chemotherapeutic agent oxaliplatin displays a wide range of antitumor activities. However, the underlying molecular responses to oxaliplatin…”
Get full text

Relationship between the in vitro response of dendritic cells to Lactobacillus and prevention of tumorigenesis in the mouse by Takagi, Akimitsu, Ikemura, Haruo, Matsuzaki, Takeshi, Sato, Mikiko, Nomoto, Koji, Morotomi, Masami, Yokokura, Teruo

“…Background Some strains of lactobacilli stimulate immune cells, yet little is known about their potency in cancer prevention. We have previously reported that…”
Get full text

Lipoteichoic acids from Lactobacillus strains elicit strong tumor necrosis factor alpha-inducing activities in macrophages through Toll-like receptor 2 by Matsuguchi, Tetsuya, Takagi, Akimitsu, Matsuzaki, Takeshi, Nagaoka, Masato, Ishikawa, Kimika, Yokokura, Teruo, Yoshikai, Yasunobu

“…Lactobacilli are nonpathogenic gram-positive inhabitants of microflora. At least some Lactobacillus strains have been postulated to have health beneficial…”
Get full text

PEGylated liposome IHL-305 markedly improved the survival of ovarian cancer peritoneal metastasis in mouse by Konishi, Hiroaki, Takagi, Akimitsu, Kurita, Akinobu, Kaneda, Norimasa, Matsuzaki, Takeshi

“…Advanced ovarian cancer is characterized by peritoneal metastasis and the accumulation of ascites. Peritoneal metastasis of ovarian cancer is a major cause of…”
Get full text

Abstract 5534: A novel and oral histone deacetylase inhibitor, resminostat, effectively suppresses the growth of non-small cell lung cancer in a xenograft mouse model by Takagi, Akimitsu, Konishi, Hiroaki, Tsugane, Momomi, Taniguchi, Keisuke, Takahashi, Hiroyuki, Inutake, Yu, Watanabe, Akinobu, Kodaira, Hiroshi, Matsuzaki, Takeshi

“…Abstract Background: Accumulating evidence reveals effectiveness of histone deacetylase (HDAC) inhibition in various types of cancer, and resminostat is a…”
Get full text

Oxaliplatin, a Potent Inhibitor of Survivin, Enhances Paclitaxel-induced Apoptosis and Mitotic Catastrophe in Colon Cancer Cells by Fujie, Yujiro, Yamamoto, Hirofumi, Ngan, Chew Yee, Takagi, Akimitsu, Hayashi, Taro, Suzuki, Rei, Ezumi, Koji, Takemasa, Ichiro, Ikeda, Masataka, Sekimoto, Mitsugu, Matsuura, Nariaki, Monden, Morito

“…Background: Clinical studies have demonstrated that oxaliplatin, a novel platinum derivative, is a potent chemotherapeutic agent, especially when combined with…”
Get full text

Enhancement of natural killer cytotoxicity delayed murine carcinogenesis by a probiotic microorganism by Takagi, Akimitsu, Matsuzaki, Takeshi, Sato, Mikiko, Nomoto, Koji, Morotomi, Masami, Yokokura, Teruo

“…Regulation of innate immunity may be an effective means of cancer control. Delaying cancer onset is regarded as an important mode of action in cancer…”
Get full text

The Biological Behavior of Prostate Cancer Cells in 3D Culture Systems by WATANABE, Masatoshi, TAKAGI, Akimitsu

“…Prostate cancer is the most common non-cutaneous malignant neoplasm in men in Western countries. In Japan, the number of afflicted men has been increasing…”
Get full text

Aberrant methylation of the vascular endothelial growth factor receptor‐1 gene in prostate cancer by Yamada, Yasushi, Watanabe, Masatoshi, Yamanaka, Mikio, Hirokawa, Yoshifumi, Suzuki, Hiroyoshi, Takagi, Akimitsu, Matsuzaki, Takeshi, Sugimura, Yoshiki, Yatani, Ryuichi, Shiraishi, Taizo

“…Transcriptional silencing of cancer‐related genes by DNA methylation is observed in various cancers. To identify genes controlled by methylation in prostate…”
Get full text

High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone by Hirokawa, Yoshifumi, Takagi, Akimitsu, Uchida, Katsunori, Kozuka, Yuji, Yoneda, Misao, Watanabe, Masatoshi, Shiraishi, Taizo

“…In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a…”
Get full text

Knowledge of epigenetic influence for prostate cancer therapy by Watanabe, Masatoshi, Takagi, Akimitsu, Matsuzaki, Takeshi, Kami, Daisuke, Toyota, Minoru, Hirokawa, Yoshifumi, Shiraishi, Taizo

“…Prostate cancer is one of the most prevalent cancers in men in many countries, increasing in frequency with age through the most advanced years. The standard…”
Get more information

Combined therapeutic effect of YHO-1701 with PD-1 blockade is dependent on natural killer cell activity in syngeneic mouse models by Takahashi, Hiroyuki, Miyoshi, Nao, Murakami, Hisashi, Okamura, Yuta, Ogo, Naohisa, Takagi, Akimitsu, Muraoka, Daisuke, Asai, Akira

“…The signal transducer and activator of transcription 3 (STAT3) signaling pathway is a key mediator of cancer cell proliferation, survival, and invasion. We…”
Get full text

Orally administered Streptococcus thermophilus YIT 2001 is a vehicle for the delivery of glutathione, a reactive reduced thiol, to the intestine by Yamamoto, Yu, Maki, Koh, Kusuhara, Shiro, Yokoi, Wakae, Tochiya, Kaoru, Okumura, Takekazu, Ito, Masahiko, Miyazaki, Kouji, Harada, Katsuhisa, Takagi, Akimitsu

“…We aimed to analyze the behavior of cellular glutathione of Streptococcus thermophilus strain YIT 2001 (ST-1) in the gastrointestinal environment to understand…”
Get full text