Search Results - "Takada, Toru"

Maternal embryonic leucine zipper kinase (MELK) optimally regulates the HIV-1 uncoating process by Nishiyama, Takara, Takada, Toru, Takeuchi, Hiroaki, Iwami, Shingo

“…•Modeling the process of core structure uncoating by MELK.•Quantifying the uncoating process in HIV-1 cDNA synthesis and nuclear trafficking.•In silico…”
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Inhibition of Autophagy at Different Stages by ATG5 Knockdown and Chloroquine Supplementation Enhances Consistent Human Disc Cellular Apoptosis and Senescence Induction rather than Extracellular Matrix Catabolism by Ito, Masaaki, Yurube, Takashi, Kanda, Yutaro, Kakiuchi, Yuji, Takeoka, Yoshiki, Takada, Toru, Kuroda, Ryosuke, Kakutani, Kenichiro

“…The intervertebral disc is the largest avascular organ. Autophagy is an important cell survival mechanism by self-digestion and recycling damaged components…”
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Prospective cohort study of surgical outcome for spinal metastases in patients aged 70 years or older by Kanda, Yutaro, Kakutani, Kenichiro, Sakai, Yoshitada, Yurube, Takashi, Miyazaki, Shingo, Takada, Toru, Hoshino, Yuichi, Kuroda, Ryosuke

“…With recent progress in cancer treatment, the number of advanced-age patients with spinal metastases has been increasing. It is important to clarify the…”
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Two-step evolution of HIV-1 budding system leading to pandemic in the human population by Konno, Yoriyuki, Uriu, Keiya, Chikata, Takayuki, Takada, Toru, Kurita, Jun-ichi, Ueda, Mahoko Takahashi, Islam, Saiful, Yang Tan, Benjy Jek, Ito, Jumpei, Aso, Hirofumi, Kumata, Ryuichi, Williamson, Carolyn, Iwami, Shingo, Takiguchi, Masafumi, Nishimura, Yoshifumi, Morita, Eiji, Satou, Yorifumi, Nakagawa, So, Koyanagi, Yoshio, Sato, Kei

“…The pandemic HIV-1, HIV-1 group M, emerged from a single spillover event of its ancestral lentivirus from a chimpanzee. During human-to-human spread worldwide,…”
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A novel topical treatment for bone metastases using a gelatin hydrogel incorporating cisplatin as a sustained release system by Kanda, Yutaro, Kakutani, Kenichiro, Yurube, Takashi, Zhang, Zhongying, Miyazaki, Shingo, Kakiuchi, Yuji, Takeoka, Yoshiki, Tsujimoto, Ryu, Miyazaki, Kunihiko, Kawamoto, Teruya, Takada, Toru, Hoshino, Yuichi, Tabata, Yasuhiko, Kuroda, Ryosuke

“…Management of bone metastasis is becoming increasingly important. Thus, local and systemic treatment options have been developed for control. Although systemic…”
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Capability of Nondegenerated and Degenerated Discs in Producing Inflammatory Agents With or Without Macrophage Interaction by HAMAMOTO, Hideki, MIYAMOTO, Hiroshi, DOITA, Minoru, TAKADA, Toru, NISHIDA, Kotaro, KUROSAKA, Masahiro

“…Molecular biological and immunohistological examinations. To clarify whether nondegenerated and degenerated discs produce inflammatory agents such as…”
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Functional impact of integrin α5β1 on the homeostasis of intervertebral discs: a study of mechanotransduction pathways using a novel dynamic loading organ culture system by Kurakawa, Takuto, MD, Kakutani, Kenichiro, MD, PhD, Morita, Yusuke, PhD, Kato, Yuki, MS, Yurube, Takashi, MD, PhD, Hirata, Hiroaki, MD, Miyazaki, Shingo, MD, Terashima, Yoshiki, MD, Maeno, Koichiro, MD, PhD, Takada, Toru, MD, PhD, Doita, Minoru, MD, PhD, Kurosaka, Masahiro, MD, PhD, Inoue, Nozomu, MD, PhD, Masuda, Koichi, MD, Nishida, Kotaro, MD, PhD

“…Abstract Background context Intervertebral disc (IVD) degeneration, a major cause of low back pain, is considered to be induced by daily mechanical loading…”
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Surgical outcomes and risk factors for poor outcomes in patients with cervical spine metastasis: a prospective study by Kanda, Yutaro, Kakutani, Kenichiro, Sakai, Yoshitada, Zhang, Zhongying, Yurube, Takashi, Miyazaki, Shingo, Kakiuchi, Yuji, Takeoka, Yoshiki, Tsujimoto, Ryu, Miyazaki, Kunihiko, Ohnishi, Hiroki, Hoshino, Yuichi, Takada, Toru, Kuroda, Ryosuke

“…Background Few studies have addressed the impact of palliative surgery for cervical spine metastasis on patients' performance status (PS) and quality of life…”
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Fas ligand expression on human nucleus pulposus cells decreases with disc degeneration processes by Kaneyama, Shuichi, Nishida, Kotaro, Takada, Toru, Suzuki, Teppei, Shimomura, Takatoshi, Maeno, Koichiro, Kurosaka, Masahiro, Doita, Minoru

“…The intervertebral disc has been reported to be an immunologically privileged environment, possibly mediated by Fas ligand (FasL) expression. On the other…”
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Fas ligand exists on intervertebral disc cells: A potential molecular mechanism for immune privilege of the disc by TAKADA, Toru, NISHIDA, Kotaro, DOITA, Minoru, KUROSAKA, Masahiro

“…Rat and human intervertebral disc specimens were examined immunohistochemically. Reverse transcription polymerase chain reaction (RT-PCR) analysis was also…”
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Sustained long-term RNA interference in nucleus pulposus cells in vivo mediated by unmodified small interfering RNA by Suzuki, Teppei, Nishida, Kotaro, Kakutani, Kenichiro, Maeno, Koichiro, Yurube, Takashi, Takada, Toru, Kurosaka, Masahiro, Doita, Minoru

“…RNA interference (RNAi) technology has recently emerged as an important biological strategy for gene silencing. Previously, the efficacies of RNAi in cultured…”
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Prospective Cohort Study of Performance Status and Activities of Daily Living After Surgery for Spinal Metastasis by Kakutani, Kenichiro, Sakai, Yoshitada, Maeno, Koichiro, Takada, Toru, Yurube, Takashi, Kurakawa, Takuto, Miyazaki, Shingo, Terashima, Yoshiki, Ito, Masaaki, Hara, Hitomi, Kawamoto, Teruya, Ejima, Yasuo, Sakashita, Akihiro, Kiyota, Naomi, Kizawa, Yoshiyuki, Sasaki, Ryohei, Akisue, Toshihro, Minami, Hironobu, Kuroda, Ryosuke, Kurosaka, Masahiro, Nishida, Kotaro

“…A prospective cohort study of performance status (PS) and activities of daily living (ADL) in patients with spinal metastasis. To identify the effect of spinal…”
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Improved bone bonding of hydroxyapatite spacers with a high porosity in a quantitative computed tomography‐image pixel analysis: A prospective 1‐year comparative study of the consecutive cohort undergoing double‐door cervical laminoplasty by Takeoka, Yoshiki, Yurube, Takashi, Maeno, Koichiro, Kanda, Yutaro, Tsujimoto, Ryu, Miyazaki, Kunihiko, Kakiuchi, Yuji, Miyazaki, Shingo, Zhang, Zhongying, Takada, Toru, Nishida, Kotaro, Doita, Minoru, Kuroda, Ryosuke, Kakutani, Kenichiro

“…Laminoplasty using hydroxyapatite (HA) spacers is widely performed in patients with cervical myelopathy. However, spacer dislocation is a critical complication…”
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Interleukin-6 production is upregulated by interaction between disc tissue and macrophages by Takada, Toru, Nishida, Kotaro, Doita, Minoru, Miyamoto, Hiroshi, Kurosaka, Masahiro

“…Interleukin (IL)-6 production was investigated using a coculture system of disc tissue and macrophages. The purpose of this study was to investigate the…”
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Tissue-engineering bone from omentum by Kamei, Yuzuru, Toriyama, Kazuhiro, Takada, Toru, Yagi, Shunjiro

“…Tissue engineering of bone is an interesting field of research. Many approaches to bone tissue engineering such as from bone marrow stromal cells in vitro have…”
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Fas-ligand expression on nucleus pulposus begins in developing embryo by INUI, Yoshihiro, NISHIDA, Kotaro, DOITA, Minoru, TAKADA, Toru, MIYAMOTO, Hiroshi, YOSHIYA, Shinichi, KUROSAKA, Masahiro

“…The expression of Fas ligand in the notochord or nucleus pulposus was examined immunohistochemically using rat embryos. To clarify at which stage of embryo…”
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Prolonged down regulation of specific gene expression in nucleus pulposus cell mediated by RNA interference in vitro by Kakutani, Kenichiro, Nishida, Kotaro, Uno, Koki, Takada, Toru, Shimomura, Takatoshi, Maeno, Koichiro, Kurosaka, Masahiro, Doita, Minoru

“…To investigate the efficacies and the longevity of RNA interference in nucleus pulposus cells from rat and human, two reporter luciferase plasmids (Firefly and…”
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Unusual metastasis to the cauda equina from renal cell carcinoma by Takada, Toru, Doita, Minoru, Nishida, Kotaro, Miura, Juichi, Yoshiya, Shinichi, Kurosaka, Masahiro

“…This is a case report of a patient with renal cell carcinoma and intradural metastasis to the cauda equina. To present a rare case of an intradural metastasis…”
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Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration by Yurube, Takashi, Takada, Toru, Suzuki, Teppei, Kakutani, Kenichiro, Maeno, Koichiro, Doita, Minoru, Kurosaka, Masahiro, Nishida, Kotaro

“…The longitudinal degradation mechanism of extracellular matrix (ECM) in the interbertebral disc remains unclear. Our objective was to elucidate catabolic and…”
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Kinematic magnetic resonance imaging of a thoracic spinal extradural arachnoid cyst: an alternative suggestion for exacerbation of symptoms during straining by Doita, Minoru, Nishida, Kotaro, Miura, Jyuichi, Takada, Toru, Kurosaka, Masahiro, Fujii, Masahiko

“…A case study of an extradural arachnoid cyst using kinematic magnetic resonance imaging. To access the dynamic and pathologic changes of an extradural…”
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