Search Results - "Takada, Akitsugu"

Evaluation of Food and Spherical Carbon Adsorbent Effects on the Pharmacokinetics of Roxadustat in Healthy Nonelderly Adult Male Japanese Subjects by Shibata, Tomohisa, Nomura, Yuki, Takada, Akitsugu, Ueno, Mai, Katashima, Masataka, Yazawa, Rie, Furihata, Kenichi

“…Roxadustat is a hypoxia‐inducible factor prolyl hydroxylase inhibitor in late‐stage clinical development for the treatment of anemia in chronic kidney disease…”
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Pharmacokinetics and Safety of Amenamevir in Healthy Subjects: Analysis of Four Randomized Phase 1 Studies by Kusawake, Tomohiro, Keirns, James J., Kowalski, Donna, den Adel, Martin, Groenendaal-van de Meent, Dorien, Takada, Akitsugu, Ohtsu, Yoshiaki, Katashima, Masataka

“…Introduction Amenamevir (ASP2151) is a nonnucleoside antiherpesvirus compound available for the treatment of varicella–zoster virus infections. In this article…”
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A phase I, open-label, single-dose micro tracer mass balance study of 14C-labeled ASP7991 in healthy Japanese male subjects using accelerator mass spectrometry by Miyatake, Daisuke, Nakada, Naoyuki, Takada, Akitsugu, Kato, Kota, Taniuchi, Yuta, Katashima, Masataka, Sawamoto, Taiji

“…ASP7991 is a calcimimetic that acts on the calcium-sensing receptor on parathyroid cell membranes and suppresses parathyroid hormone (PTH) secretion in the…”
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A phase I, open-label, single-dose micro tracer mass balance study of 14 C-labeled ASP7991 in healthy Japanese male subjects using accelerator mass spectrometry by Miyatake, Daisuke, Nakada, Naoyuki, Takada, Akitsugu, Kato, Kota, Taniuchi, Yuta, Katashima, Masataka, Sawamoto, Taiji

“…ASP7991 is a calcimimetic that acts on the calcium-sensing receptor on parathyroid cell membranes and suppresses parathyroid hormone (PTH) secretion in the…”
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Integrative pharmacokinetic–pharmacodynamic modeling and simulation of amenamevir (ASP2151) for treatment of recurrent genital herpes by Takada, Akitsugu, Katashima, Masataka, Kaibara, Atsunori, Chono, Koji, Katsumata, Kiyomitsu, Sawamoto, Taiji, Suzuki, Hiroshi, Yano, Yoshitaka

“…Amenamevir is a novel drug that targets the viral helicase–primase complex. While dose-dependent efficacy had been observed in non-clinical studies, no clear…”
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The Influence of Hepatic and Renal Impairment on the Pharmacokinetics of a Treatment for Herpes Zoster, Amenamevir (ASP2151): Phase 1, Open-Label, Single-Dose, Parallel-Group Studies by Kusawake, Tomohiro, Kowalski, Donna, Takada, Akitsugu, Kato, Kota, Katashima, Masataka, Keirns, James J., Lewand, Michaelene, Lasseter, Kenneth C., Marbury, Thomas C., Preston, Richard A.

“…Introduction Amenamevir (ASP2151) is a nonnucleoside human herpesvirus helicase-primase inhibitor that was approved in Japan for the treatment of herpes zoster…”
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Population pharmacokinetics of roxadustat in Japanese dialysis‐dependent chronic kidney disease patients with anaemia by Takada, Akitsugu, Shibata, Tomohisa, Shiga, Takanori, Groenendaal‐van de Meent, Dorien, Komatsu, Kanji

“…Aims Our objective was to develop a population pharmacokinetic (PK) model to describe roxadustat plasma concentrations in Japanese dialysis‐dependent chronic…”
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Pharmacokinetic/pharmacodynamic modeling of roxadustat's effect on LDL cholesterol in patients in Japan with dialysis-dependent chronic kidney disease and anemia by Takada, Akitsugu, Shibata, Tomohisa, Shiga, Takanori, Ugawa, Tohru, Komatsu, Kanji, Akizawa, Tadao

“…The objective of this analysis was to develop and evaluate a pharmacokinetic/pharmacodynamic (PK/PD) model of the effect of roxadustat on low-density…”
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Population Pharmacokinetics Analysis of Quetiapine Extended-release Formulation in Japanese Patients with Bipolar Depression by Fukushi, Risa, Nomura, Yuki, Katashima, Masataka, Komatsu, Kanji, Sato, Yuichiro, Takada, Akitsugu

“…The objectives of this study were to explore covariates of plasma quetiapine concentrations after oral administration of quetiapine extended-release…”
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Approach to Evaluating QT Prolongation of Quetiapine Fumarate in Late Stage of Clinical Development Using Concentration-QTc Modeling and Simulation in Japanese Patients With Bipolar Disorder by Fukushi, Risa, Nomura, Yuki, Katashima, Masataka, Komatsu, Kanji, Sato, Yuichiro, Takada, Akitsugu

“…Quetiapine has been reported to prolong the QT interval, and has been used as a positive control in thorough QT studies. The objective of the present study was…”
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Quantification of ASP2151 in Human Plasma and Urine: A Pitfall Associated with Supersaturation of Analyte in Urine by Ohtsu, Yoshiaki, van Trigt, Radboud, Takama, Kaori, Groenendaal, Dorien, Takada, Akitsugu, Nakamura, Takeshi, Noguchi, Kiyoshi

“…This is a case study of the difficulties caused by supersaturation of an analyte during the quantification of a drug in urine. To support the clinical…”
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Pharmacokinetics of an Elevated Dosage of Micafungin in Premature Neonates by Smith, P Brian, Walsh, Thomas J, Hope, William, Arrieta, Antonio, Takada, Akitsugu, Kovanda, Laura L, Kearns, Gregory L, Kaufman, David, Sawamoto, Taiji, Buell, Donald N, Benjamin, Daniel K

“…BACKGROUND:Determining the safety and pharmacokinetics of antifungal agents in neonates is important. A previous single-dose pharmacokinetic study of…”
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Population pharmacokinetic modeling of Sepantronium bromide (YM155), a small molecule survivin suppressant, in patients with non-small cell lung cancer, hormone refractory prostate cancer, or unresectable stage III or IV melanoma by Aoyama, Yumiko, Kaibara, Atsunori, Takada, Akitsugu, Nishimura, Tetsuya, Katashima, Masataka, Sawamoto, Taiji

“…Summary Purpose Population pharmacokinetics (PK) of sepantronium bromide (YM155) was characterized in patients with non-small cell lung cancer, hormone…”
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Pharmacokinetic Evaluation of the Interactions of Amenamevir (ASP2151) with Ketoconazole, Rifampicin, Midazolam, and Warfarin in Healthy Adults by Kusawake, Tomohiro, den Adel, Martin, Groenendaal-van de Meent, Dorien, Garcia-Hernandez, Alberto, Takada, Akitsugu, Kato, Kota, Ohtsu, Yoshiaki, Katashima, Masataka

“…Introduction Amenamevir is a nonnucleoside antiherpes virus compound available for treating herpes zoster infections. Four studies aimed to determine any…”
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PK–PD modeling of 1-(3- C-ethynyl-β- d- ribo-pentofuranosyl)cytosine and the enhanced antitumor effect of its phospholipid derivatives in long-circulating liposomes by Takada, Akitsugu, Kamiya, Hiroyuki, Shuto, Satoshi, Matsuda, Akira, Harashima, Hideyoshi

“…The efficacy of an antitumor nucleoside, 1-(3- C-ethynyl-β- d- ribo-pentofuranosyl)cytosine (3′-ethynylcytidine, ECyd), was analyzed in vitro and in vivo. The…”
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An Open‐Label, Single‐Dose, Human Mass Balance Study of Amenamevir in Healthy Male Adults by Kato, Kota, den Adel, Martin, Groenendaal‐van de Meent, Dorien, Ohtsu, Yoshiaki, Takada, Akitsugu, Katashima, Masataka

“…Amenamevir is an inhibitor of the helicase‐primase enzyme complex developed for the treatment of varicella zoster virus. This mass balance study investigated…”
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Statistical analysis of Amenamevir (ASP2151) between pharmacokinetics and clinical efficacies with non-linear effect model for the treatment of genital herpes by Takada, Akitsugu, Katashima, Masataka, Kaibara, Atsunori, Sawamoto, Taiji, Zhang, Wenhui, Keirns, James

“…Amenamevir is the international non‐proprietary name for ASP2151 synthesized by Astellas Pharma, Inc. It is a structurally novel class of helicase‐primase…”
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