Search Results - "Takaai, Mari"

Membrane Transport Mechanisms of Quinidine and Procainamide in Renal LLC-PK1 and Intestinal LS180 Cells by Masago, Miki, Takaai, Mari, Sakata, Jumpei, Horie, Asuka, Ito, Toshikazu, Ishida, Kazuya, Taguchi, Masato, Hashimoto, Yukiya

“…The aim of the present study was to compare the membrane transport mechanisms of procainamide with those of quinidine using renal epithelial LLC-PK1 and…”
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Membrane Transport Mechanisms of Mizoribine in the Rat Intestine and Human Epithelial LS180 Cells by Ishida, Kazuya, Takaai, Mari, Yotsutani, Ayano, Taguchi, Masato, Hashimoto, Yukiya

“…The aim of the present study was to characterize membrane transport mechanisms of mizoribine in the intestinal epithelial cells. We evaluated the contribution…”
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Pharmacokinetic Analysis of Transcellular Transport of Levofloxacin across LLC-PK1 and Caco-2 Cell Monolayers by Takaai, Mari, Suzuki, Hisaki, Ishida, Kazuya, Tahara, Katsutoshi, Hashimoto, Yukiya

“…To characterize the membrane transport responsible for the renal excretion and intestinal absorption of levo-floxacin, we performed pharmacokinetic analysis of…”
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Population pharmacokinetics of mizoribine in pediatric patients with kidney disease by Kaneda, Hisashi, Shimizu, Masaki, Ohta, Kazuhide, Ushijima, Katsumi, Gotoh, Yoshimitsu, Satomura, Kenichi, Nagai, Takuhito, Fujieda, Mikiya, Morooka, Masashi, Yamada, Takuji, Yamada, Masayoshi, Wada, Naohiro, Takaai, Mari, Hashimoto, Yukiya, Uemura, Osamu

“…Background The present study aimed to obtain information enabling optimisation of the clinical effect of mizoribine (MZR) in pediatric patients with kidney…”
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Contribution of Na +-independent nucleoside transport to ribavirin uptake in the rat intestine and human epithelial LS180 cells by Takaai, Mari, Morishita, Hiroki, Ishida, Kazuya, Taguchi, Masato, Hashimoto, Yukiya

“…The aim of the present study was to characterize the intestinal absorption of ribavirin (1-β- d-ribofuranosyl-1, 2, 4-trizole-3-carboxamide). We evaluated the…”
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Pharmacokinetic Analysis of Transcellular Transport of Quinidine across Monolayers of Human Intestinal Epithelial Caco-2 Cells by Ishida, Kazuya, Takaai, Mari, Hashimoto, Yukiya

“…To investigate the mechanism responsible for the intestinal absorption of a lipophilic organic cation, quinidine, we performed a pharmacokinetic analysis of…”
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Directional Transcellular Transport of Bisoprolol in P-glycoprotein-expressed LLC-GA5-COL150 Cells but not in Renal Epithelial LLC-PK1 Cells by Tahara, Katsutoshi, Kagawa, Yuka, Takaai, Mari, Taguchi, Masato, Hashimoto, Yukiya

“…To evaluate the mechanism responsible for the tubular secretion of bisoprolol, we compared transcellular transport of bisoprolol with that of…”
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Nonlinear Mixed Effects Model Analysis of the Pharmacokinetics of Aripiprazole in Healthy Japanese Males by Koue, Toshiko, Kubo, Masanori, Funaki, Tomoo, Fukuda, Tsuyoshi, Azuma, Junichi, Takaai, Mari, Kayano, Yuichiro, Hashimoto, Yukiya

“…The population pharmacokinetic parameters of aripiprazole in healthy Japanese males were estimated using a nonlinear mixed effects model (NONMEM) program…”
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Additional Notes on Clinical Repeated-Dose Pharmacokinetic Trials Applying a Peak-and-Trough Sampling Design to Estimate Oral Clearance by Takaai, Mari, Kayano, Yuichiro, Shimizu, Takako, Taguchi, Masato, Hashimoto, Yukiya

“…In the previous study, we performed a simulation of a clinical pharmacokinetic trial, in which blood was sampled at two time points corresponding to the peak…”
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Evaluation of Limited Sampling Designs to Estimate Maximal Concentration and Area under the Curve of Mizoribine in Pediatric Patients with Renal Disease by Ishida, Kazuya, Kaneda, Hisashi, Uemura, Osamu, Ushijima, Katsumi, Ohta, Kazuhide, Goto, Yoshimitsu, Satomura, Kenichi, Shimizu, Masaki, Fujieda, Mikiya, Morooka, Masashi, Yamada, Takuji, Yamada, Masayoshi, Wada, Naohiro, Takaai, Mari, Hashimoto, Yukiya

“…The aim of this study was to evaluate limited sampling designs to estimate the maximal concentration (C max) and area under the curve (AUC) of mizoribine in…”
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The Apical Uptake Transporter of Levofloxacin is Distinct from the Peptide Transporter in Human Intestinal Epithelial Caco-2 Cells by Fukumori, Shiro, Murata, Toshiya, Takaai, Mari, Tahara, Katsutoshi, Taguchi, Masato, Hashimoto, Yukiya

“…The aim of this study was to investigate the involvement of the peptide transporter for absorption of levofloxacin in Caco-2 cells. To evaluate the activity of…”
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Evaluation of Limited Sampling Designs to Estimate Maximal Concentration and Area under the Curve of Mizoribine in Pediatric Patients with Renal Disease by Kazuya ISHIDA, Hisashi KANEDA, Osamu UEMURA, Katsumi USHIJIMA, Kazuhide OHTA, Yoshimitsu GOTO, Kenichi SATOMURA, Masaki SHIMIZU, Mikiya FUJIEDA, Masashi MOROOKA, Takuji YAMADA, Masayoshi YAMADA, Naohiro WADA, Mari TAKAAI, Yukiya HASHIMOTO

“…Summary: The aim of this study was to evaluate limited sampling designs to estimate the maximal concentration (Cmax) and area under the curve (AUC) of…”
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Directional Transcellular Transport of Bisoprolol in P-glycoprotein-expressed LLC-GA5-COL150 Cells, but not in Renal Epithelial LLC-PK1 Cells by Katsutoshi TAHARA, Yuka KAGAWA, Mari TAKAAI, Masato TAGUCHI, Yukiya HASHIMOTO

“…[Summary] To evaluate the mechanism responsible for the tubular secretion of bisoprolol, we compared transcellular transport of bisoprolol with that of…”
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Contribution of Na super(+)-independent nucleoside transport to ribavirin uptake in the rat intestine and human epithelial LS180 cells by Takaai, Mari, Morishita, Hiroki, Ishida, Kazuya, Taguchi, Masato, Hashimoto, Yukiya

“…The aim of the present study was to characterize the intestinal absorption of ribavirin (1- beta -d-ribofuranosyl-1, 2, 4-trizole-3-carboxamide). We evaluated…”
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