Search Results - "Tajeddin, N"
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Novel islands of GGC and GCC repeats coincide with human evolution
Published in Gene (15-04-2024)“…•Genome-wide identification of GGC and GCC islands as a novel genomic entity.•Human-specificity of some of the islands.•Prime instances of directional…”
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A GCC repeat in RAB26 undergoes natural selection in human and harbors divergent genotypes in late-onset Alzheimer's disease
Published in Gene (30-01-2024)“…Although mainly located in genic regions and being mutation hotspots, intact blocks of CG-rich trinucleotide short tandem repeats (STRs) are largely overlooked…”
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A Hypermutable Region in the DISP2 Gene Links to Natural Selection and Late-Onset Neurocognitive Disorders in Humans
Published in Molecular neurobiology (01-11-2024)“…(CCG) short tandem repeats (STRs) are predominantly enriched in genic regions, mutation hotspots for C to T truncating substitutions, and involved in various…”
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Dyads of GGC and GCC form hotspot colonies that coincide with the evolution of human and other great apes
Published in BMC genetics (21-02-2024)“…GGC and GCC short tandem repeats (STRs) are of various evolutionary, biological, and pathological implications. However, the fundamental two-repeats (dyads) of…”
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